Volume 41 Issue 12
Dec.  2019
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Guo-qing JIANG, Xing-li DENG, Xiao-juan LI, Yuan QIAN. Analysis of lncRNA-mRNA Co-expression Network in Invasive Pituitary Adenomas[J]. Journal of Kunming Medical University, 2020, 41(12): 42-48. doi: 10.12259/j.issn.2095-610X.S20201214
Citation: Guo-qing JIANG, Xing-li DENG, Xiao-juan LI, Yuan QIAN. Analysis of lncRNA-mRNA Co-expression Network in Invasive Pituitary Adenomas[J]. Journal of Kunming Medical University, 2020, 41(12): 42-48. doi: 10.12259/j.issn.2095-610X.S20201214

Analysis of lncRNA-mRNA Co-expression Network in Invasive Pituitary Adenomas

doi: 10.12259/j.issn.2095-610X.S20201214
  • Received Date: 2020-03-14
  • Publish Date: 2019-12-26
  •   Objective   To screen differentially expressed lncRNAs in invasive pituitary adenomas by second-generation sequencing, and to explore their potential role in the pathogenesis of invasive pituitary adenomas.   Methods   The expressions of lncRNA and mRNA in 4 patients with invasive pituitary adenoma and 3 patients with non-invasive pituitary adenoma were analyzed by RNA sequencing to single out the differentially expressed lncRNA and mRNA. Accordingly, lncrNA-mRNA co-expression networks were constructed and GO and KEGG pathways were analyzed.   Results   A total of 35 differentially expressed lncRNAs and 463 differentially expressed mRNAs were obtained by analyzing the differentially expressed lncRNAs and mRNAs in both invasive and non-invasive pituitary tumors. The co-expression network showed that FAM66A, TPTEP1, AC017116.11, RP11-1114A5.4 and RP11-246K15.1 were in a key position in the network.   Conclusion   Through the establishment of co-expression network of lncRNA-mRNA, we found that some new lncRNA may play a key role in the pathogenesis of invasive pituitary adenomas and may be used as novel biomarkers of invasive pituitary adenomas.
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