The Diagnostic Efficacy of Alveolar Lavage Fluid G test and GM Test in AECOPD Complicated with Invasive Pulmonary Fungal Infection

Ying ZHANG; Xiao-qun NIU

doi:10.12259/j.issn.2095-610X.S20201217

Volume 41 Issue 12

Dec. 2019

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 55-59

Ying ZHANG, Xiao-qun NIU. The Diagnostic Efficacy of Alveolar Lavage Fluid G test and GM Test in AECOPD Complicated with Invasive Pulmonary Fungal Infection[J]. Journal of Kunming Medical University, 2020, 41(12): 55-59. doi: 10.12259/j.issn.2095-610X.S20201217

Citation:

Ying ZHANG, Xiao-qun NIU. The Diagnostic Efficacy of Alveolar Lavage Fluid G test and GM Test in AECOPD Complicated with Invasive Pulmonary Fungal Infection[J]. Journal of Kunming Medical University, 2020, 41(12): 55-59. doi: 10.12259/j.issn.2095-610X.S20201217

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The Diagnostic Efficacy of Alveolar Lavage Fluid G test and GM Test in AECOPD Complicated with Invasive Pulmonary Fungal Infection

doi: 10.12259/j.issn.2095-610X.S20201217

Ying ZHANG,
Xiao-qun NIU^,

Dept. of Emergency and Intensive Care Medicine，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-04-21
Publish Date: 2019-12-26

Abstract

Abstract

Objective To evaluate the diagnostic efficacy of alveolar lavage fluid（1, 3）-beta-D-glucan（G）test and galactomannan（GM）test in early diagnosis of acute exacerbations of chronic obstructive pulmonary disease（AECOPD）complicated with invasive pulmonary fungal infection（IPFI）. Methods A total of 26 AECOPD patients with pulmonary fungal infection admitted to the Department of Emergency and Intensive Care Medicine, the Second Affiliated Hospital of Kunming Medical University from October 2018 to October 2019 were randomly selected as the experimental group, and another 26 AECOPD patients admitted in the same period only with bacterial infection were selected as the control group. The serum and BALF G and GM test results of the two groups, as well as the diagnostic efficacy of G and GM tests were analyzed. Results In the observation group, 22 cases were alveolar lavage fluid G test positive, 18 cases were GM test positive; 20 cases were serum G test positive, 16 cases were serum GM test positive; 23 cases were positive for G combined with GM test in alveolar lavage fluid, and 22 cases were positive for serum G combined GM test. The sensitivity, specificity, positive predictive value, negative predictive value, false positive rate and false negative rate of alveolar lavage fluid G test combined with GM test were 88.5%、92.3%、93.5%、93.2%、7.7%和11.5%, respectively, P < 0.05. Conclusion G and GM test in alveolar lavage fluid has a high diagnostic efficacy in the early diagnosis of AECOPD complicated with invasive pulmonary fungal infection, with G and GM test in alveolar lavage fluid better than G and GM test in serum.

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References(18)

References

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