Expression of HPV16E6 and Indoleamine 2, 3-dioxygenase in Cervical Lesions and Its Clinical Implications

Lin-lin YANG; Chun-mei YIN; Lei ZHANG; Wei WANG; Ling-feng ZHAO; Yu-die YANG; He ZHAO; Ying LIU

doi:10.12259/j.issn.2095-610X.S20201219

Volume 41 Issue 12

Dec. 2019

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 68-72

Lin-lin YANG, Chun-mei YIN, Lei ZHANG, Wei WANG, Ling-feng ZHAO, Yu-die YANG, He ZHAO, Ying LIU. Expression of HPV16E6 and Indoleamine 2, 3-dioxygenase in Cervical Lesions and Its Clinical Implications[J]. Journal of Kunming Medical University, 2020, 41(12): 68-72. doi: 10.12259/j.issn.2095-610X.S20201219

Citation:

Lin-lin YANG, Chun-mei YIN, Lei ZHANG, Wei WANG, Ling-feng ZHAO, Yu-die YANG, He ZHAO, Ying LIU. Expression of HPV16E6 and Indoleamine 2, 3-dioxygenase in Cervical Lesions and Its Clinical Implications[J]. Journal of Kunming Medical University, 2020, 41(12): 68-72. doi: 10.12259/j.issn.2095-610X.S20201219

Citation:

Lin-lin YANG, Chun-mei YIN, Lei ZHANG, Wei WANG, Ling-feng ZHAO, Yu-die YANG, He ZHAO, Ying LIU. Expression of HPV16E6 and Indoleamine 2, 3-dioxygenase in Cervical Lesions and Its Clinical Implications[J]. Journal of Kunming Medical University, 2020, 41(12): 68-72. doi: 10.12259/j.issn.2095-610X.S20201219

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Expression of HPV16E6 and Indoleamine 2, 3-dioxygenase in Cervical Lesions and Its Clinical Implications

doi: 10.12259/j.issn.2095-610X.S20201219

Dept. of Gynecology，The 3rd Affiliated Hospital of Kunming Medical University，The Cancer Hospital of Yunnan Province，Kunming Yunnan 650118，China

Received Date: 2020-04-18
Publish Date: 2019-12-26

Abstract

Abstract

Objective To explore the potential of HPV16E6 and IDO as a tumor markers of cervical cancer, the expression of high-risk HPV-infected normal cervical tissue, cervical precancerous lesions, cervical cancer tissue HPV16E6 and IDO, the correlation between HPV16E6 and IDO in the progression of cervical lesions were analyzed. Methods 120 cases of cervical lesions with high-risk HPV infection detected by HPV DNA in the second generation hybrid capture（HC-2）method were used as experimental subjects, 40 cases each in normal cervical tissue group, cervical precancerous lesions group and cervical cancer tissues group, respectively. The expression of HPV16E6 and IDO in each tissue group was detected by immunohistochemical staining. Results The expression rates of HPV16E6 and IDO in 40 cases of normal cervical tissues were 7.5% and 0%, respectively. The expression rates of HPV16E6 and IDO in 40 cases of cervical precancerous lesions were 37.5% and 22.5%, respectively. The positive expression rates of HPV16E6 and IDO in 40 cases of cervical cancer tissues were 90% and 80%, respectively. The positive expression of HPV16E6 and IDO was positively correlated in the progression of cervical lesions（r_s = 0.710, P = 0.000）. Conclusion The expression of HPV16E6 and IDO showed a positive trend with the progress of cervical lesions. HPV16E6 and IDO have the potential of tumor markers for predicting the progression cervical lesions.
- HPV,
- Cervical lesion tissue,
- HPV16E6,
- IDO

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References(16)

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