Volume 41 Issue 12
Dec.  2019
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Qing-qing XIONG, Xiao-dong LUO, Bu-fang FU, Jia-yi ZHONG, Guo-lian HE. Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas[J]. Journal of Kunming Medical University, 2020, 41(12): 85-88. doi: 10.12259/j.issn.2095-610X.S20201224
Citation: Qing-qing XIONG, Xiao-dong LUO, Bu-fang FU, Jia-yi ZHONG, Guo-lian HE. Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas[J]. Journal of Kunming Medical University, 2020, 41(12): 85-88. doi: 10.12259/j.issn.2095-610X.S20201224

Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas

doi: 10.12259/j.issn.2095-610X.S20201224
  • Received Date: 2020-03-26
  • Publish Date: 2019-12-26
  •   Objective   To observe the effect of dexmedetomidine on respiration in postoperative patients undergone general anesthesia at high altitude areas.   Methods   60 patients who received laparoscopic cholecystectomy under tracheal general anesthesia, and all the patients had been living in high altitude area (altitude: 2000 m~3000 m) for at least one year. The patients were randomly assigned into two groups. The dexmedetomidine group received a 10-minute- infusion of dexmedetomidine 0.6 μg/kg, while the control group was given a volume-matched normal saline in same dose. After operation, the tracheal tube was removed and then oxygen 3 L/min was given. A rapid arterial blood gas examination was performed one hour after operation. At the time points of 1 hour, 3 hours, 6 hours and 12 hours after operation, we examined the blood oxygen saturation and the respiratory rate, and recorded the number of patients with hypoxemia in both groups (Hypoxemia was considered to be present when blood oxygen saturation was ≤ 85%).   Results   The oxygen partial pressure at each postoperative point in both groups was higher than that before surgery (P < 0.05), and there was no statistically significant difference in oxygen partial pressure at each postoperative point in the two groups ( P > 0.05). Oxygen saturation at each time point after operation in both groups was higher than that before operation ( P < 0.05), and oxygen saturation at 3 h after operation in the dexmedetomidine group was lower than that in the control group ( P < 0.05). The respiration rate of the dexmedetomidine group at 1 h, 3 h and 12 h after operation was lower than that of the control group ( P < 0.05). No oxygen saturation below 85% was found in both groups after operation.   Conclusion   The administration of dexmedetomidine to patients under tracheal general anesthesia at high altitude areas will reduce the number of breaths and blood oxygen saturation at some time points, but it will not reduce the partial pressure of oxygen at 1 min after surgery, and will not cause postoperative hypoxemia.
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