Study on the Correlation between Vernal Keratoconjunctivitis and Dry Eye Syndrome in Children

Xiao-bo ZENG; Jiang-tao XU; Min DENG; Zheng-cui NIE; Rui-meng YUAN; Ting-yan ZHU

doi:10.12259/j.issn.2095-610X.S20201225

Volume 41 Issue 12

Dec. 2019

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 89-93

Xiao-bo ZENG, Jiang-tao XU, Min DENG, Zheng-cui NIE, Rui-meng YUAN, Ting-yan ZHU. Study on the Correlation between Vernal Keratoconjunctivitis and Dry Eye Syndrome in Children[J]. Journal of Kunming Medical University, 2020, 41(12): 89-93. doi: 10.12259/j.issn.2095-610X.S20201225

Citation:

Xiao-bo ZENG, Jiang-tao XU, Min DENG, Zheng-cui NIE, Rui-meng YUAN, Ting-yan ZHU. Study on the Correlation between Vernal Keratoconjunctivitis and Dry Eye Syndrome in Children[J]. Journal of Kunming Medical University, 2020, 41(12): 89-93. doi: 10.12259/j.issn.2095-610X.S20201225

Citation:

Xiao-bo ZENG, Jiang-tao XU, Min DENG, Zheng-cui NIE, Rui-meng YUAN, Ting-yan ZHU. Study on the Correlation between Vernal Keratoconjunctivitis and Dry Eye Syndrome in Children[J]. Journal of Kunming Medical University, 2020, 41(12): 89-93. doi: 10.12259/j.issn.2095-610X.S20201225

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Study on the Correlation between Vernal Keratoconjunctivitis and Dry Eye Syndrome in Children

doi: 10.12259/j.issn.2095-610X.S20201225

Dept. of Ophthalmology，Kunming Children’s Hospital，Childern’s Hospital affiliated to Kunming Medical University，Kunming Yunnan 650034，China

Received Date: 2020-04-12
Publish Date: 2019-12-26

Abstract

Abstract

Objective To evaluate the condition of dry eyes in children with vernal keratoconjunctivitis in spring, and to explore the clinical characteristics as well as correlation with the severity of the disease. Method 65 children who were diagnosed with VKC in outpatient department from January to June in 2015 were recruited as the observation group. The control group consisted of 65 normal children matched in age and sex. Dry eye questionnaire, slit-lamp examination, break-up time test（BUT）, fluorescein staining（FL）and Lid-wiper staining of Lid-wiper epitheliopathy（LWE）were performed in both groups. Statistical analyses were used to assessing these data. Results （1）The dry eye symptom scores of children with vernal keratoconjunctivitis in spring were significantly higher than those of normal children（Z = -8.589 P < 0.01）. Photophobia（23.59%）, foreign body sensation（18.08%）, frequent blinking（14.49%）and uncomfortable in windy conditions（20.90%）are the most common symptoms in VKC children.（2）The score of slit-lamp examination in VKC children was significantly higher than that in the normal group（Z = -9.902, P < 0.01）.（3）The BUT was significantly shorter in VKC children（7.06±3.51）than in normal children（13.34±4.82）（Z = -6.729 P < 0.01）. FL score（1.82±1.69）was significantly higher than that of normal children（0.23±0.46）（Z = -6.355 P < 0.01）. The score of LWE（1.03±1.00）was significantly higher than that of normal children（0.31±0.50）（Z = -4.463 P < 0.01）.（4）For VKC children, the severity of dry eye symptoms is correlated with slit-lamp checking scores（ r = 0.259 P < 0.05）; FL scores are also correlated with slit-lamp checking scores（r = 0.269 P < 0.05）; these children's BUT scores are correlated with FL（ r = -0.283 P < 0.05）and LWE（ r = -0.252 P < 0.05）scores; FL scores are correlated with LWE scores（ r = 0.307 P < 0.05）. Conclusion Dry eyes do exist in VKC children. The severity of dry eye is correlated with the severity of VKC inflammation. This study provides a basis for further study on pathophysiology of dry eye in VKC children, as well as a reason for the use of artificial tears in acute stage of VKC.
- Vernal keratoconjunctivitis,
- Dry eye,
- Lid-wiper epitheliopathy

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References(10)

References

[1]	Vazquez Nava F,Salas Ralningz E,MogicaMogicaJdeD,et al. Prevalence and risk factors for allergic conjunctivitis in children. Comparative study in two communities[J]. Rev Alerg Mex,2002,49(2):33-41.
[2]	Lobefalo L D,Antonio E,Colangelo L,et al. Dry eye in allergic conjunctivitis:Role of inflammatory infiltrate[J]. Int J Immunopathol Pharmacol,1999,12(3):133-137.
[3]	Kramer J H,Mannis M J. Seborrhea and meibomian gland dysfunction[J]. Cornea,2004,38(5):485-491.
[4]	洛非,邹留河. 儿童干眼症的初步研究[J].眼科,2006,15(6):411-413. doi: 10.3969/j.issn.1004-4469.2006.06.015
[5]	Ozcura F,Aydin S,Helvaci M R. Ocular surface disease index for the diagnosis of dry eye syndrome[J]. Ocul Iimmunol Iinflamm,2007,15(5):389-393. doi: 10.1080/09273940701486803
[6]	晏晓明,刘爽,李海丽. 眼睑刷上皮病变与干眼相关性的初步观察[J].中华眼科杂志,2008,44(5):436-441. doi: 10.3321/j.issn:0412-4081.2008.05.012
[7]	Donald R Korb,John P Herman,Jack V Greiner,et al. Lid Wiper Epitheliopathy and Dry Eye Symptoms[J]. Eye & Contact Lens,2005,31(1):2-8.
[8]	Donald R Korb,John P Herman,Caroline A Blackie,et al. Prevalence of lid wiper epitheliopathy in subjects with dry eye signs and symptoms[J]. Cornea,2010,29(4):377-383. doi: 10.1097/ICO.0b013e3181ba0cb2
[9]	Efron N,Brennan N A,Morgan P B,et al. Lid wiper epitheliopathy[J]. Prog Retin Eye Res,2016,53(7):140-174.
[10]	Wing Li,Thao N Yeh,Tiana Leung,et al. The relationship of lid wiper epitheliopathy to ocularsurface signs and symptoms[J]. Invest Ophthalmol Vis Sci,2018,59(5):1878-1887. doi: 10.1167/iovs.17-23639

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