Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol

Wei-jia ZHAO; Hong-bin LI; Zong-han CHEN

doi:10.12259/j.issn.2095-610X.S20201227

Volume 41 Issue 12

Dec. 2019

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 99-103

Wei-jia ZHAO, Hong-bin LI, Zong-han CHEN. Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol[J]. Journal of Kunming Medical University, 2020, 41(12): 99-103. doi: 10.12259/j.issn.2095-610X.S20201227

Citation:

Wei-jia ZHAO, Hong-bin LI, Zong-han CHEN. Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol[J]. Journal of Kunming Medical University, 2020, 41(12): 99-103. doi: 10.12259/j.issn.2095-610X.S20201227

Citation:

Wei-jia ZHAO, Hong-bin LI, Zong-han CHEN. Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol[J]. Journal of Kunming Medical University, 2020, 41(12): 99-103. doi: 10.12259/j.issn.2095-610X.S20201227

PDF( 606 KB)

Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol

doi: 10.12259/j.issn.2095-610X.S20201227

1.
Dept. of Dermatology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan， 650032
2.
Higher Education Research and Evaluation Center，Yunnan University of Traditional Chinese Medicine，Kunming Yunnan 650500，China

Received Date: 2020-06-23
Publish Date: 2020-12-25

Abstract

Abstract

Objective To analyze the clinical efficacy of narrow-spectrum UVB in the treatment of psoriasis and the effect on peripheral blood cytokines. Methods 109 patients with psoriasis treated in the First Affiliated Hospital of Kunming Medical University from May 2018 to March 2020 were selected and randomly divided into experimental group（n = 55）and control group（n = 54）. The control group was treated with capotriol ointment, and the experimental group was treated with narrow-spectrum UVB combined with capotriol ointment. The clinical efficacy and the changes of cytokines in peripheral blood of patients in the two groups were compared. Results The total effective rate of clinical treatment in the experimental group was higher than that of control group, and the difference was statistically significant（P < 0.05）. After treatment, Th17, Treg and Th17/Treg in the experimental group were statistically significant in control group（ P < 0.05）. After treatment, TNF- radiation and il-10 in the experimental group were compared with those in the control group, and the difference was statistically significant（ P < 0.05）. Conclusion Narrow spectrum UVB treatment of psoriasis can improve the clinical outcomes, which may be related to the inhibition of serum TNF- beam and Th17 levels in patients with psoriasis, and the improvement of 1l-10 and Treg cell levels. UVB in narrow spectrum may play a role in improving Th17/Treg imbalance ratio and cytokine levels in patients with psoriasis, which has great potential in clinical practice.
- Narrow spectrum,
- UVB rays,
- Carpotriol,
- Psoriasis,
- Clinical outcome,
- Cytokines

FullText(HTML)

References(14)

References

[1]	张爱玲, 孟海阳, 杨莉萍, 等. 托法替布治疗中、重度银屑病的疗效及安全性的系统评价和Meta分析[J]. 中国药学杂志, 2019, 54（8）: 665-670.
[2]	史玉玲. 生物制剂在银屑病治疗中的研究进展[J]. 世界临床药物, 2019, 40（11）: 758-764.
[3]	史玉玲. 中国银屑病诊疗指南（2018版）解读[J]. 同济大学学报（医学版）, 2019, 40（3）: 265-267.
[4]	殷文浩, 金梦祝, 丁韧烨. 寻常型银屑病患者血清HPA和VEGF水平检测及与PASI评分的相关性分析[J]. 中国中西医结合皮肤性病学杂志, 2018, 17（5）: 395-397. doi: 10.3969/j.issn.1672-0709.2018.05.005
[5]	李锘, 押丽静, 王磊, 等. 清热凉血方对IMQ诱导银屑病小鼠模型IL-17A、IL-10的影响及miR-210激动剂的干预作用[J]. 中国皮肤性病学杂志, 2019, 33（8）: 885-889.
[6]	周发琼, 雷淑英, 吴明珠. MIF水平及MIF-173G/C多态性与恩施地区土家族银屑病关联性研究[J]. 河北医药, 2015, 33（3）: 331-333.
[7]	王卿, 王大虎, 王爱学, 等. 银屑病患者损伤处皮肤间充质干细胞对T细胞增殖的影响[J]. 中国组织工程研究, 2016, 20（23）: 3451-3456. doi: 10.3969/j.issn.2095-4344.2016.23.016
[8]	李玲. 黄芪注射液对寻常型银屑病患者微循环及氧化应激状态的影响研究[J]. 世界中西医结合杂志, 2015, 10（7）: 962-964.
[9]	张方圆, 杨家彬, 魏蔚, 等. 他克莫司对银屑病皮损分离培养的T细胞分泌γ干扰素和白细胞介素4、17、10的影响[J]. 临床皮肤科杂志, 2018, 47（4）: 218-219.
[10]	雷田兵, 罗模桂, 刘官智. 阿维A联合窄谱中波紫外线治疗寻常性银屑病的疗效及其对患者外周血细胞因子IFN-γ、IL-4及IL-17的影响[J]. 海南医学, 2016, 27（13）: 2118-2120. doi: 10.3969/j.issn.1003-6350.2016.13.019
[11]	雷杰豪, 樊奇敏, 陈荣, 等. 白癜风患者窄谱中波紫外线治疗效果与光疗反应的关系及相关因素分析[J]. 中华皮肤科杂志, 2019, 52（4）: 259-262.
[12]	许文斌, 于建春, 温明菲, 等. 针刺配合窄谱中波紫外线照射治疗老年性皮肤瘙痒症38例[J]. 中国针灸, 2018, 38（12）: 1277-1278, 1292.
[13]	熊文君, 罗小军. 老年性皮肤瘙痒症的中西医治疗研究进展[J]. 现代中西医结合杂志, 2016, 25（33）: 3757-3759, 3762.
[14]	王惠琳, 孟继龙, 张伟伟, 等. 窄谱中波紫外线治疗对寻常性银屑病患者Th17/Treg失衡的影响[J]. 实用皮肤病学杂志, 2018, 11（5）: 266-269.

Relative Articles(20)

Relative Articles

[1]	Shibing QIAN, Huiping SHI, Yanqiu LI, Rongyu YANG, Kaiwen DUAN. Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells. Journal of Kunming Medical University, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926
[2]	Fen LI, Jie ZHAO, Haixi ZHANG, Lin ZHANG, Xuezhong GU. The Correlation of Iron Metabolism Indexes，Cytokines，and Liver Function in Patients with Hemophagocytic Syndrome. Journal of Kunming Medical University, 2024, 45(11): 110-116. doi: 10.12259/j.issn.2095-610X.S20241115
[3]	Yanhong YANG, Juan HE, Shan JIN, Piaopiao YE, Xin LI, Li QIAO. Prediction of Psoriasis and Potential Treatment of Traditional Chinese Medicine Based on Reverse Network Pharmacology Analysis. Journal of Kunming Medical University, 2024, 45(12): 1-9.
[4]	Cuihua FANG, Maohua PAN, Longcan ZHOU, Yucheng QIN, Yaming HUANG, Jia MA, Xi CHEN, Zhaoqing YANG. Current Status and Research Progress of Immunotherapy for Melanoma. Journal of Kunming Medical University, 2023, 44(5): 175-179. doi: 10.12259/j.issn.2095-610X.S20230519
[5]	Jianfang DONG, Xijing YIN, Zucong CHEN, Xuefei ZHANG, Zeping ZHOU. Research progress of immune-related molecules in primary immune thrombocytopenia. Journal of Kunming Medical University, 2023, 44(1B): 1-6.
[6]	Yaling ZHAO, Kun WU, Kai WANG, Rong HUANG, Genya HE, Yuhui NA, Miao HE, Zhenbo DING, Caiying ZHANG. Influence of Intrauterine Hyperglycemia Environment on Peripheral Inflammatory Response in Offspring of Gestational Diabetes Mellitus. Journal of Kunming Medical University, 2023, 44(11): 70-75. doi: 10.12259/j.issn.2095-610X.S20231110
[7]	Kun ZHAO, Yun XIAO, Chun YANG, Zhiling YAN, Minna DONG, Bingquan XIANG, Mingyao XIAO. Protective Effect of Interleukin-4 in Lipopolysaccharide-induced Acute Lung Injury Models. Journal of Kunming Medical University, 2022, 43(8): 41-46. doi: 10.12259/j.issn.2095-610X.S20220805
[8]	Xing LIU, Hai-wen LI, Hong-li HUANG, Lin-jun SHEN, Le ZHANG, Xiang-fang LIU, Wen-lin ZHANG, Lu WANG. Effects of Probiotics Enhanced Enteral Nutrition on Gastrointestinal Function and Cytokines in Patients with Severe Acute Pancreatitis. Journal of Kunming Medical University, 2021, 42(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20211116
[9]	Jin-rong YANG, Kun WU, Bo NIE, Zhen-xin HE, Yu-yu YANG, Jie SUN, Yun ZENG. Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis. Journal of Kunming Medical University, 2021, 42(12): 51-58. doi: 10.12259/j.issn.2095-610X.S20211220
[10]	Wei-sha ZHOU, Le ZHANG, Jing PENG, Shou-kun CHEN, Meng-jun LIU, Xiao FU, Zhi-fei TANG, Yun-xuan YUE. Effect of Plasma Exchange with Double Plasma Molecular Adsorption on Cytokines in Autoimmune Hepatitis with Liver Failure. Journal of Kunming Medical University, 2021, 42(4): 73-77. doi: 10.12259/j.issn.2095-610X.S20210414
[11]	Hui GOU, Xian-qiong FENG, Qin ZOU. Correlation Analysis and Influencing Factors of Social Support and Medication Adherence in Patients with Psoriasis. Journal of Kunming Medical University, 2021, 42(11): 122-127. doi: 10.12259/j.issn.2095-610X.S20211122
[12]	Lv Song Qin , Zhao Hua , Bao Fu Kai , Li Xiao Fei , Yan Xin Li , Zhang Juan , Duan Hong Fen . Combined Application of TNF-α,IFN-γ and T-SPOT.TB in Identification between Active Tuberculosis Infection and Latent Tuberculosis Infection. Journal of Kunming Medical University, 2017, 38(04): 93-97.
[13]	Liu Shao Xing . Effect of Parecoxib Sodium Pretreatment on Permeability of Blood-Brain Barrier in a Rat Model of Focal Cerebral Ischemia-reperfusion Injury. Journal of Kunming Medical University,
[14]	Zhang Yang . . Journal of Kunming Medical University,
[15]	Xue En Zhong . . Journal of Kunming Medical University,
[16]	Yang Jing . . Journal of Kunming Medical University,
[17]	Yang De Xing . . Journal of Kunming Medical University,
[18]	Zhou Yi Zhong . . Journal of Kunming Medical University,
[19]	Wu Shang Min . . Journal of Kunming Medical University,
[20]	Li Yu Xiao . . Journal of Kunming Medical University,