Comparative Study of Neutrophil Elastase and Total Antioxidant Capacity in Serum of COPD Patients with Different HRCT Phenotypes

Hong-bo CHEN; Li-ping CHEN; Yong-ming JIN; Li-na WANG; Li-rui ZHU; Rong-qiong SHEN

doi:10.12259/j.issn.2095-610X.S20201229

Volume 41 Issue 12

Dec. 2019

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 108-111

Xiaolin LIU, Xiaocui CHEN, Yang SUN, Minli LI, Yinglei MIAO. Clinical Efficacy and Safety Evaluation of Fecal Bacteria Transplantation by Different Ways on Ulcerative Colitis[J]. Journal of Kunming Medical University, 2022, 43(6): 46-51. doi: 10.12259/j.issn.2095-610X.S20220612

Citation:

Hong-bo CHEN, Li-ping CHEN, Yong-ming JIN, Li-na WANG, Li-rui ZHU, Rong-qiong SHEN. Comparative Study of Neutrophil Elastase and Total Antioxidant Capacity in Serum of COPD Patients with Different HRCT Phenotypes[J]. Journal of Kunming Medical University, 2020, 41(12): 108-111. doi: 10.12259/j.issn.2095-610X.S20201229

Citation:

PDF( 560 KB)

Comparative Study of Neutrophil Elastase and Total Antioxidant Capacity in Serum of COPD Patients with Different HRCT Phenotypes

doi: 10.12259/j.issn.2095-610X.S20201229

Dept.of Respiratory Medicine，Anning people’s Hospital，Kunming Yunnan 653100，China

Received Date: 2020-03-26
Publish Date: 2019-12-26

Abstract

Abstract

Objective To explore the neutrophil elastase（neutrophil elastase, NE）, total antioxidant capacity（total antioxidative capability, T - AOC）in chronic obstructive pulmonary disease（chronic obstructive pulmonary diseases, COPD）high-resolution CT（high-resolution computed tomography, HRCT）in different HRCT phenotypes. Methods HRCT was used for typing 78 patients with out-patient COPD into phenotype A, phenotype M and phenotype E; NE and T-AOC of the three groups of patients were tested. Results The serum NE concentration of phenotype M in COPD patients was higher than that of control group, phenotype A and phenotype E（P < 0.05）. The serum NE concentration of phenotype E was higher than that of control group and phenotype A（ P < 0.05）. There was no significant difference in T-AOC between the three groups and the control group（ P > 0.05）. The NE in serum was negatively correlated with FEV1 and FEV1% pred.（ P < 0.05）, and positively correlated with CAT score（ P < 0.05）. Conclusion The expression of NE in COPD patients with different HRCT phenotypes is up-regulated and correlated with lung function indicators, and NE may be involved in airway inflammation and airway remodeling in COPD and cause airflow obstruction.
- Chronic obstructive pulmonary diseases,
- Phenotype,
- HRCT,
- Serum neutrophil elastase,
- Total antioxidant capacity

FullText(HTML)

References(19)

References

[1]	中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南[J].中华结核和呼吸杂志,2013,36(4):255-264. doi: 10.3760/cma.j.issn.1001-0939.2013.04.007
[2]	蒋辉,朱清艺,毕迎春,等. MMP-9/TIMP-l与COPD肺气肿关系研究进展[J].辽宁中医药大学学报,2013,15(6):1166-1167.
[3]	Mocchegiani E,Giacconi R,Costarelli L. Metalloproteases/anti-metalloproteases inbalance in chronic obstructive pulmonary disease:Enetic factors and treatment implications[J]. Curr Opin Pulm Med,2011,17(s1):11-19.
[4]	Dransfield M T,Washko G R,Foreman M G,et al. Genderdifferences in the severityof CT emphysema in COPD[J]. Chest,2007,132(2):464-470. doi: 10.1378/chest.07-0863
[5]	Han M K,Agusti A,Calverley P M. Chronic obstructive pulmonarydisease phenophenotypes:Thefuture of COPD[J]. Am J Respir Crit Care Med,2010,182(5):592-604.
[6]	Fujimoto K,Kitaguchi Y,KuboK,et al. Clinical annlysis ofchronic obstructive pulmonarydisease phenophenotypes classifiedusing high-resolution computedtomography[J]. Respirology,2006,11(6):731-740. doi: 10.1111/j.1440-1843.2006.00930.x
[7]	Barneg P J. Chronic obstructive pulmonary disease[J]. N Eng J Med,2000,343(4):269-280. doi: 10.1056/NEJM200007273430407
[8]	Han M K,Kazerooni E A,Lynch D A,et a1. Chronic obstructive pulmonary disease exacerbationsin the COPD Gene study:Associated radiologic phenophenotypes[J]. Radiology,2011,261(1):274-282. doi: 10.1148/radiol.11110173
[9]	Saetta M,Turato G,Maestrelli P,et al. Cellular and structural bases ofchronic obstructure pulmonary disease[J]. Am J Respir Crit Care Med,2001,163(6):1304-1309. doi: 10.1164/ajrccm.163.6.2009116
[10]	Lee W L,Downey G P. Leukocyte elastase:physiological functions and role in acute lung injury[J]. AmJ Respir Crit Care Med,2001,164(5):896-904.
[11]	骆元正,肖玉艳,赵玲珑,等. 中性粒细胞弹性蛋白酶在慢性阻塞性肺疾病发病中的作用[J].天津医药,2012,40(4):391-392. doi: 10.3969/j.issn.0253-9896.2012.04.029
[12]	王嘉,孙武装,王鹏羽,等. 慢性阻塞性肺疾病患者血清蛋白酶与抗胰蛋白酶的表达及意义[J].山东医药,2012,52(21):54-56. doi: 10.3969/j.issn.1002-266X.2012.21.020
[13]	Makita H,Nasuhara Y,Naqai K,et a1. Characterization of phenophenotypes based on severity of emphysema in chronic obstructive pulmonary disease[J]. Thorax,2007,62(11):932-937. doi: 10.1136/thx.2006.072777
[14]	Fischer B M,Cuellar J G,Diehl M L,et a1. Neutrophilelastase increases MUC4 expression in normal human bronchial epithelial cells[J]. Am J Physiol LungCell Mol Physiol,2003,284(4):L671-L679. doi: 10.1152/ajplung.00220.2002
[15]	Voynow J A,Gendler S J,Rose M C. Regulation of mucin genes in chronic inflammatory airway diseases[J]. Am J Respir Cell Mol Biol,2006,34(6):661-665. doi: 10.1165/rcmb.2006-0035SF
[16]	曾春芳,王笑,何清. 中性粒细胞弹性蛋白酶在慢性阻塞性肺疾病患者肺组织中的表达及其与气流受限的关系[J].四川医学,2017,38(10):1110-1111.
[17]	李雪华,张洪玉,庞宝森. 慢性阻塞性肺疾病患者痰中性粒细胞弹性蛋白酶和基质金属蛋白酶9的表达及其与气流受限的关系[J].中华结核和呼吸杂志,2007,30(7):553-554. doi: 10.3760/j.issn:1001-0939.2007.07.018
[18]	蒋蕊,杜永成,张新日,等. 雷公藤多甙对哮喘大鼠血清及肺组织NO含量和总抗氧化能力的影响[J].山西医科大学学报,2008,39(4):313.
[19]	官秋玥,向征. 慢性阻塞性肺疾病中蛋白酶与抗蛋白酶系统的研究进展[J].国际呼吸杂志,2014,34(8):1186-1187.

Relative Articles(20)

Relative Articles

[1]	Zhao NA, Hang YANG, Li CHEN, Chuanxin LI, Han XIAO, Qiang BAI. Clinical Value of Matrix Metalloproteinase 7，Glutamyl Transferase，and Total Bile Acids in the Joint Diagnosis of Biliary Atresia. Journal of Kunming Medical University, 2025, 46(): 1-6.
[2]	Jinmei LU, Yuzhu LI, Lin WANG, Xin SU, Jinxiu LIN, Jianhui ZHANG. Study on the Effectiveness of Wearable Device-based Lung Rehabilitation in Patients with COPD. Journal of Kunming Medical University, 2023, 44(11): 175-182. doi: 10.12259/j.issn.2095-610X.S20231127
[3]	Qian HUANG, Meihua LI, Xiaojing TANG, Wei MA, Yanxia YANG, Qingling ZHENG, Jin HE. Correlation of Lung Function and HRCT Bronchial Wall Thickness in Patients with Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2022, 43(2): 118-121. doi: 10.12259/j.issn.2095-610X.S20220224
[4]	Feng Yi , Cai Bing , Wang Feng , Wang Mao De . . Journal of Kunming Medical University, 2020, 41(03): 10-16.
[5]	Zhao Xiao Li , Tang Shu Rong , Wang Si Chen , Qian Jing , Ren Bao Jun , Zeng Wen , Hu Da Chun . Changes of Cellular Immune Function in Chronic Obstructive Pulmonary Disease Patients with Infection. Journal of Kunming Medical University, 2019, 40(03): 49-52.
[6]	Qiao Qian , Hao Ying Lu , Li Yan Ping , Liu Hai Ying , Li Ting Ting , Qian Bao Tang , Liu Fang Yan . Genetic Screening of Familial Hypertrophic Cardiomyopathy in Yuxi Yunnan. Journal of Kunming Medical University, 2018, 39(02): 34-38.
[7]	Tai Xiao Li , Zhou Xiao Li , Zhou Wei Hua . The Effects of Clinical Pathway of Nursing on Pulmonary Function Index and Complications in Patients with COPD. Journal of Kunming Medical University, 2018, 39(02): 138-142.
[8]	Zhao Jie . The Expression and Significance of Galectin-3 in COPD and Lung Cancer. Journal of Kunming Medical University,
[9]	Gu Fang Na . . Journal of Kunming Medical University,
[10]	He Xiao Yu . . Journal of Kunming Medical University,
[11]	Zhao Jie . . Journal of Kunming Medical University, 2015, 36(05): 1-1.
[12]	Li Wang . . Journal of Kunming Medical University,
[13]	Wang Zhu Jun . . Journal of Kunming Medical University,
[14]	Dong Zhao Xing . . Journal of Kunming Medical University,
[15]	Chen Ya Ping . . Journal of Kunming Medical University,
[16]	Chen Ya Ping . . Journal of Kunming Medical University,
[17]	Ju Hong Ping . . Journal of Kunming Medical University,
[18]	. . Journal of Kunming Medical University,
[19]	. Effects of Enalapril on Serum Ang- Ⅱ Expression and Mucus Hypersecretion in Patients with COPD in Stable Stage. Journal of Kunming Medical University,
[20]	Li Xiao Lan . . Journal of Kunming Medical University,