Comparative Study of Neutrophil Elastase and Total Antioxidant Capacity in Serum of COPD Patients with Different HRCT Phenotypes

Hong-bo CHEN; Li-ping CHEN; Yong-ming JIN; Li-na WANG; Li-rui ZHU; Rong-qiong SHEN

doi:10.12259/j.issn.2095-610X.S20201229

Volume 41 Issue 12

Dec. 2019

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Yang Jie . Effect of Slug and Sox9 on the Invasion and Metastasis of Nasopharyngeal Carcinoma Stem Cells[J]. Journal of Kunming Medical University, 2016, 37(01).

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Hong-bo CHEN, Li-ping CHEN, Yong-ming JIN, Li-na WANG, Li-rui ZHU, Rong-qiong SHEN. Comparative Study of Neutrophil Elastase and Total Antioxidant Capacity in Serum of COPD Patients with Different HRCT Phenotypes[J]. Journal of Kunming Medical University, 2020, 41(12): 108-111. doi: 10.12259/j.issn.2095-610X.S20201229

Yang Jie . Effect of Slug and Sox9 on the Invasion and Metastasis of Nasopharyngeal Carcinoma Stem Cells[J]. Journal of Kunming Medical University, 2016, 37(01).

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Comparative Study of Neutrophil Elastase and Total Antioxidant Capacity in Serum of COPD Patients with Different HRCT Phenotypes

doi: 10.12259/j.issn.2095-610X.S20201229

Dept.of Respiratory Medicine，Anning people’s Hospital，Kunming Yunnan 653100，China

Received Date: 2020-03-26
Publish Date: 2019-12-26

Abstract

Abstract

Objective To explore the neutrophil elastase（neutrophil elastase, NE）, total antioxidant capacity（total antioxidative capability, T - AOC）in chronic obstructive pulmonary disease（chronic obstructive pulmonary diseases, COPD）high-resolution CT（high-resolution computed tomography, HRCT）in different HRCT phenotypes. Methods HRCT was used for typing 78 patients with out-patient COPD into phenotype A, phenotype M and phenotype E; NE and T-AOC of the three groups of patients were tested. Results The serum NE concentration of phenotype M in COPD patients was higher than that of control group, phenotype A and phenotype E（P < 0.05）. The serum NE concentration of phenotype E was higher than that of control group and phenotype A（ P < 0.05）. There was no significant difference in T-AOC between the three groups and the control group（ P > 0.05）. The NE in serum was negatively correlated with FEV1 and FEV1% pred.（ P < 0.05）, and positively correlated with CAT score（ P < 0.05）. Conclusion The expression of NE in COPD patients with different HRCT phenotypes is up-regulated and correlated with lung function indicators, and NE may be involved in airway inflammation and airway remodeling in COPD and cause airflow obstruction.
- Chronic obstructive pulmonary diseases,
- Phenotype,
- HRCT,
- Serum neutrophil elastase,
- Total antioxidant capacity

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