Molecular Epidemiology of Human Rhinovirus in 2 260 Children with Acute Lower Respiratory Tract Infection

Li TAN; Ming LI; Yu-xing SUN; Zhen ZHANG; Zheng-yan GAN

doi:10.12259/j.issn.2095-610X.S20201233

Volume 41 Issue 12

Dec. 2019

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 119-122

Li TAN, Ming LI, Yu-xing SUN, Zhen ZHANG, Zheng-yan GAN. Molecular Epidemiology of Human Rhinovirus in 2 260 Children with Acute Lower Respiratory Tract Infection[J]. Journal of Kunming Medical University, 2020, 41(12): 119-122. doi: 10.12259/j.issn.2095-610X.S20201233

Citation:

Li TAN, Ming LI, Yu-xing SUN, Zhen ZHANG, Zheng-yan GAN. Molecular Epidemiology of Human Rhinovirus in 2 260 Children with Acute Lower Respiratory Tract Infection[J]. Journal of Kunming Medical University, 2020, 41(12): 119-122. doi: 10.12259/j.issn.2095-610X.S20201233

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Molecular Epidemiology of Human Rhinovirus in 2 260 Children with Acute Lower Respiratory Tract Infection

doi: 10.12259/j.issn.2095-610X.S20201233

Li TAN^{1, 2},
Ming LI^{1, 2},
Yu-xing SUN^{1, 2},
Zhen ZHANG^{1, 2},
Zheng-yan GAN^{1, 2
,
,}

1.
Dept. of Respiratory Medicine，Kunming Children’s Hospital
2.
Dept. of Respiratory Medicine，Children’s Hospital Affiliated to Kunming Medical University， Kunming Yunnan 650228，China

Received Date: 2020-05-22
Publish Date: 2019-12-26

Abstract

Abstract

Objective To investigate the molecular epidemiological characteristics of human rhinovirus (HRV) infection in hospitalized children with acute lower respiratory tract infection (ALRTI) in Kunming. Methods A total of 2260 children with ALRTI who were hospitalized in Kunming children's Hospital from January 2019 to December 2019 were selected. HRV was detected by reverse transcription polymerase chain reaction (RT-PCR) in nasopharyngeal aspirates or sputum. 40 HRV positive samples were randomly selected to amplify VP4 / VP2 gene fragment, and the amplified products were sequenced and their types were identified. Results The positive rate of HRV was 6.50% (147 / 2260). There was no significant difference in HRV positive rate among different age groups (χ² = 3.240, P = 0.356). The positive rate of HRV in children with ALRTI was significantly different in different seasons, the peak is in summer, followed by autumn (χ² = 37.674, P < 0.05). Among the 40 positive samples, 23 were HRV-A, 5 were HRV-B and 12 were HRV-C. There was no significant difference in fever and cough between HRV positive and HRV negative children ( P > 0.05), but there was significant difference in wheezing ( P < 0.05). Conclusion HRV is one of the pathogens of acute lower respiratory tract infection in Kunming area. The epidemic season is summer and autumn and HRV-A is the main type. Children infected with HRV are more likely to have wheezing.
- Rhinovirus,
- Respiratory tract infection,
- Children,
- Epidemiology

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