Coagulation Function in Patients with Obstructive Sleep Apnea Hypopnea

Chun-Xia HE; Zhi-Juan LIU; Li AI; Yong-Xia LI

doi:10.12259/j.issn.2095-610X.S20201235

Volume 41 Issue 12

Dec. 2019

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Chun-Xia HE, Zhi-Juan LIU, Li AI, Yong-Xia LI. Coagulation Function in Patients with Obstructive Sleep Apnea Hypopnea[J]. Journal of Kunming Medical University, 2020, 41(12): 123-127. doi: 10.12259/j.issn.2095-610X.S20201235

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Chun-Xia HE, Zhi-Juan LIU, Li AI, Yong-Xia LI. Coagulation Function in Patients with Obstructive Sleep Apnea Hypopnea[J]. Journal of Kunming Medical University, 2020, 41(12): 123-127. doi: 10.12259/j.issn.2095-610X.S20201235

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Coagulation Function in Patients with Obstructive Sleep Apnea Hypopnea

doi: 10.12259/j.issn.2095-610X.S20201235

Dept. of the Respiratory Medicine，2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-05-10
Publish Date: 2019-12-26

Abstract

Abstract

Objective To investigate the correlation between OSA with different severity and coagulation function and sleep respiratory monitoring index by detecting the level of coagulation function in OSA patients with different severity. Methods A total of 184 patients undergoing sleep breathing monitoring in the Department of Respiratory Medicine of the Second Affiliated Hospital of Kunming Medical University from January 2018 to January 2020 were selected. According to apnea Hypopnea index（AHI）, patients were divided into 3 groups, including 50 patients in the normal control group（group A）, 45 patients in the mild OSA group（group B）, and 86 patients in the moderate-severe OSA group（group C） . The differences of coagulation function indexes and sleep respiratory monitoring indexes in the normal control group, the mild OSA group and the moderate and severe OSA group were compared, and the correlation between coagulation function indexes and AHI, LSaO2 and LAT were analyzed. Results There were no statistically significant differences in APTT, INR, PTR, FIB, TT, d-dimer, AT and FDPs between group A, B and C（P > 0.05）, no statistically significant differences in PT between group A and B（ P > 0.05）; The PT value of group C was significantly higher than that of group A and B（ P < 0.05）. Compared with group A and Group B, the AHI and LAT values of group C were significantly higher than those of group B and Group A, while those of group B were higher than those of group A. LSaO2 in group A and B was significantly different from that in group C; and FDPs of OSA group was negatively correlated with LSaO2（r = -0.157, P < 0.05）. There was no significant difference in LSaO2 between group A and group B（ P > 0.05）; In OSA group, FDPs was negatively correlated with LSaO2（R = -0.157, P < 0.05）. Conclusion PT prolonged among moderate-severe OSA patients, and FDPs is negatively correlated with LSaO2 in OSA patients, thus affecting coagulation function.
- Obstructive sleep apnea,
- Coagulation,
- PT

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References(19)

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