Efficacy of T-SPOT.TB in Treatment of Active Tuberculosis

Rong WAN; Ming-wu LI; Meng MA; Ming-hong LAI; Guang-mei Li

doi:10.12259/j.issn.2095-610X.S20201237

Volume 41 Issue 12

Dec. 2019

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Rong WAN, Ming-wu LI, Meng MA, Ming-hong LAI, Guang-mei Li. Efficacy of T-SPOT.TB in Treatment of Active Tuberculosis[J]. Journal of Kunming Medical University, 2020, 41(12): 133-137. doi: 10.12259/j.issn.2095-610X.S20201237

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Rong WAN, Ming-wu LI, Meng MA, Ming-hong LAI, Guang-mei Li. Efficacy of T-SPOT.TB in Treatment of Active Tuberculosis[J]. Journal of Kunming Medical University, 2020, 41(12): 133-137. doi: 10.12259/j.issn.2095-610X.S20201237

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Efficacy of T-SPOT.TB in Treatment of Active Tuberculosis

doi: 10.12259/j.issn.2095-610X.S20201237

No.2 Dept. of Tuberculosis，The 3rd People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2020-04-23
Publish Date: 2020-12-25

Abstract

Abstract

Objective To explore the significance of T-SPOT.TB test for monitoring the therapeutic effect of tuberculosis. Methods Using T-SPOT.TB kit, changes in response to ESAT-6 and CFP-10 were compared in 79 patients with active pulmonary tuberculosis before and after 2 months of treatment. Results In 79 patients with active pulmonary tuberculosis, The spot number of ESAT-6 and CFP-10 responses decreased significantly at the end of 2 months and at the end of treatment compared with the beginning of treatment, and the difference was statistically significant（P < 0.05）. The negative rates of ESAT-6 and CFP-10 at the end of 2 months and at the end of treatment were higher than those at the beginning of treatment, but there was no significant difference between them（ P > 0.05）. The T-SPOT.TB negative conversion rate of all patients was 3.8%.There was a statistical difference in ESAT-6 response between the end of 2 months and the end of treatment（ χ² = 4.635, P = 0.031 < 0.05）.There was no significant difference in CFP-10 response at the end of treatment 2 and at the end of treatment（ χ² = 1.272, P = 0.259 > 0.05）. Conclusion There were significant differences in ESAT-6 and CFP-10 of T-SPOT.TB responses before and after treatment. T-SPOT has a certain significance in evaluating of the therapeutic effect of tuberculosis, but its negative conversion ration can not be used as the indicator of ending the TB treatment.
- T-SPOT.TB,
- ESAT - 6,
- CFP - 10,
- Tuberculosis,
- Treatment effect

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References(14)

References

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