Volume 41 Issue 12
Dec.  2019
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Xiao-ying WANG, Zuo-jin LIU, Li-juan SHEN. Review of Correlation between Ischemia-reperfusion Injury and Pyroptosis[J]. Journal of Kunming Medical University, 2020, 41(12): 142-147. doi: 10.12259/j.issn.2095-610X.S20201240
Citation: Xiao-ying WANG, Zuo-jin LIU, Li-juan SHEN. Review of Correlation between Ischemia-reperfusion Injury and Pyroptosis[J]. Journal of Kunming Medical University, 2020, 41(12): 142-147. doi: 10.12259/j.issn.2095-610X.S20201240

Review of Correlation between Ischemia-reperfusion Injury and Pyroptosis

doi: 10.12259/j.issn.2095-610X.S20201240
  • Received Date: 2020-05-14
  • Publish Date: 2019-12-26
  • Ischemia-reperfusion injury is temporary tissue ischemia caused by pathological factors or treatments. After restoring blood flow, it causes tissue damage, which can lead to related organ dysfunction. This injury is closely related to the inflammatory injury occurring in the cells in each organ. Pyroptosis is a type of programmed cell death associated with inflammation that is morphologically similar to apoptosis. In recent years, a number of studies demonstrated that the pathogenesis of ischemia-reperfusion injury may be related to pyroptosis. The activation of various inflammatory factors during pyroptosis plays a key role in this process. This paper provides a review on the association between pyroptosis and ischemia-reperfusion injury of heart, brain, liver and kidney.
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