Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People

Li DENG; Hong-li FANG; Guang-qiong CAO; Hui-fang GAO

doi:10.12259/j.issn.2095-610X.S20210107

Volume 42 Issue 1

Jan. 2021

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2021 > 42(1): 157-160

Li DENG, Hong-li FANG, Guang-qiong CAO, Hui-fang GAO. Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People[J]. Journal of Kunming Medical University, 2021, 42(1): 157-160. doi: 10.12259/j.issn.2095-610X.S20210107

Citation:

Li DENG, Hong-li FANG, Guang-qiong CAO, Hui-fang GAO. Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People[J]. Journal of Kunming Medical University, 2021, 42(1): 157-160. doi: 10.12259/j.issn.2095-610X.S20210107

Citation:

PDF( 598 KB)

Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People

doi: 10.12259/j.issn.2095-610X.S20210107

Dept. of Health Management Center，The First Affiliated Hospital of Kumming Medical University，Kunming Yunnan 650032，China

Received Date: 2020-08-12
Available Online: 2021-01-26
Publish Date: 2021-01-26

Abstract

Abstract

Objective To explore the relationship between serum homocysteine（Hcy）and blood lipid in physical examination population and provide the evidence for the mechanism research between Hcy and lipid level. Methods 234 health examinees who came to the health management center of a grade A hospital in Yunnan Province from January 2019 to November 2019 were randomly selected as the subjects. General information, smoking, drinking and diabetes histories of the cases were collected. Plasma homocysteine, blood lipid were measured. Statistical analysis software SPSS 17.0 was used to analyze the level of Hcy and its influencing factors on blood lipid. Results （1）The value of Hcy Md（QR）for males was 12.36（9.90）μmol/L, for females was 7.73（6.40）μmol/L. There was a significant difference between males and females.（2）Smoking history（KW = 15.335, P < 0.001）, drinking history（KW = 18.937, P < 0.001）, LDL-C（r = 0.304, P = 0.002）、TC（r = 0.294, P = 0.003）were all correlated with blood Hcy level. Conclusion Total serum cholesterol（TC）, low density lipoprotein（LDL-C）are all correlated with blood Hcy level. And smoking, drinking and men are also related to the increase of Hcy level. It is necessary to strengthen the monitoring of the level of Hcy in the risky population and do more research about the relationship between Hcy and blood lipid.
- Homocysteine,
- Blood lipid,
- Correlation research

FullText(HTML)

References(18)

References

[1]	赵冬. 新中国成立70年来我国人群血脂流行病学研究回顾与进展[J].中国医药,2019,14(10):1441-1444. doi: 10.3760/j.issn.1673-4777.2019.10.001
[2]	李燕. 同型半胱氨酸与疾病的关系[J].继续医学教育,2020,34(6):79-81. doi: 10.3969/j.issn.1004-6763.2020.06.044
[3]	Antoniades C,Antonopoulos A S,Tousoulis D,et al. Homocysteine and coronary atherosclerosis:from folate fortification to the recent clinical trials[J]. European Heart Journal,2009,30(1):6-15.
[4]	张素华,陈旭虞,陈樱君,等. 家族遗传高脂血症患者血清同型半胱氨酸水平变化及意义[J].山东医药,2018,58(22):74-76. doi: 10.3969/j.issn.1002-266X.2018.22.023
[5]	陈利,余超. 血同型半胱氨酸与高脂血症的相关性研究[J].现代医学与健康研究电子杂志,2018,2(12):75.
[6]	刘国荣,徐永平,陈伟彬. 血浆同型半胱氨酸与颈动脉粥样硬化的相关分析[J].中华老年心脑血管病杂志,2020,22(03):285-287. doi: 10.3969/j.issn.1009-0126.2020.03.016
[7]	吴英浪,路英杰,王晓云. 同型半胱氨酸代谢紊乱对内皮功能障碍影响的研究进展[J].医学综述,2020,26(13):2513-2517,2522. doi: 10.3969/j.issn.1006-2084.2020.13.004
[8]	Peng H,Man C,Xu J,et al. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality:A meta-analysis of prospective studies[J]. Journal of Zhejiang University-Science B,2015,16(1):78-86.
[9]	Veeranna V,Zalawadiya S K,Niraj A,et al. Homocysteine and reclassification of cardiovascular disease risk[J]. Journal of the American College of Cardiology,2011,58(10):1025-1033. doi: 10.1016/j.jacc.2011.05.028
[10]	李敏,刘迎春,李海蓉,等. 东营地区4 109例城乡人群血浆同型半胱氨酸及合并心血管危险因素的调查分析[J].临床神经病学杂志,2017,30(6):439-442. doi: 10.3969/j.issn.1004-1648.2017.06.011
[11]	Takamura N,Abe Y,Nakazato M,et al. Determinants of plasma homecysteine levers and catrotid intima-media thickness in Japanese[J]. Asia Pac J Clin Nutr,2007,16(4):698-703.
[12]	张冰,热比亚·努力,焦谊,等. 870例中青年人群中高同型半胱氨酸血症及其影响因素分析[J].新疆医科大学学报,2019,42(9):1118-1121. doi: 10.3969/j.issn.1009-5551.2019.09.003
[13]	Sakuta H,Suzuki T. Alcohol consumption and plasma homocysteine[J]. Alcohol,2005,37(2):73-77. doi: 10.1016/j.alcohol.2005.12.005
[14]	Lakshman R,Garige M,Gong M,et al. Is alcohol beneficial or harmful for cardioprotection[J]. Genes & Nutrition,2010,5(2):111-120.
[15]	王雅楠,李治纲,张超,等. 同型半胱氨酸通过促进脂肪组织TRB3表达抑制PI3K/Akt信号通路[J].昆明医科大学学报,2017,38(6):15-18. doi: 10.3969/j.issn.1003-4706.2017.06.004
[16]	丛林海,曹光琼,李昕,等. 昆明市中老年人高同型半胱氨酸血症流行状况及其影响因素[J].昆明医科大学学报,2019,40(10):113-116. doi: 10.3969/j.issn.1003-4706.2019.10.025
[17]	王颖,邹永秋,陈泽琨,等. 高同型半胱氨酸血症与血脂异常的相关性研究[J]. 中国动脉硬化杂志,2019,27(10):887-892.
[18]	Momin M,Jia J,Fan F,et al. Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population[J]. Lipids in Health and Disease,2017,16(1):54. doi: 10.1186/s12944-017-0441-6

Relative Articles(20)

Relative Articles

[1]	Yuyun YOU, Yunfei HONG, Xia ZHENG, Feifei LIU, Jinsong YIN. The Association between Serum Homocysteine to High-density Lipoprotein Cholesterol Ratio and Premature Coronary Heart Disease. Journal of Kunming Medical University, 2025, 46(4): 1-7.
[2]	Yuyun YOU, Jinsong YIN, Yunfei HONG, Xia ZHENG, Feifei LIU. The Predictive Value of Changes in Serum Uric Acid and Homocysteine Levels in Patients with Stable Coronary Artery Disease. Journal of Kunming Medical University, 2025, 46(2): 95-102. doi: 10.12259/j.issn.2095-610X.S20250214
[3]	Qian LI, Puqiong FENG, Qin YAO, Hanmei CHEN, Ting ZHAO, Hui WU. Risk Factors of Recurrence in Patients with Ischemic Stroke Treated with Aspirin Single Drug Antiplatelet Therapy. Journal of Kunming Medical University, 2024, 45(1): 78-82. doi: 10.12259/j.issn.2095-610X.S20240113
[4]	Xinyi MEN, Jing ZHAO, Yongchun SHEN, Hui JI, Xiuxia WANG. The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis. Journal of Kunming Medical University, 2024, 45(12): 122-128. doi: 10.12259/j.issn.2095-610X.S20241217
[5]	Guang-qiong CAO, Li DENG, Hong-li FANG, Hui-fang GAO, Shuai Kui. A Longitudinal Cohort Study on the Effects of Homocysteine on Blood Pressure, Blood Glucose and Blood Lipid in Physical Examination Population in Kunming. Journal of Kunming Medical University, 2021, 42(6): 76-81. doi: 10.12259/j.issn.2095-610X.S20210603
[6]	Wang Ya Zhou , Huang Qin , Li Xiao Ming , Zhang Du Fei , Wei Dao . . Journal of Kunming Medical University, 2020, 41(02): 87-90.
[7]	Hou Yun He , Zhang Hao Xin , Wang Yi Yu , Su Yan Mei , Gu Dan Shan , Lin Shao Fang , Yang Shi Kun , Li Shu De . Regulatory Mechanism of Ginsenoside Rg1 on Homocysteine in NAFLD Model. Journal of Kunming Medical University, 2018, 39(04): 27-33.
[8]	Zhang Mei . The Effect of High Homocysteine on Blood Glucose Control in Type 2 Diabetic Patients. Journal of Kunming Medical University,
[9]	Zhang Hong Shan . . Journal of Kunming Medical University,
[10]	Liu Shi Jie . . Journal of Kunming Medical University,
[11]	Shen Yue Ling . . Journal of Kunming Medical University,
[12]	Cai Ya Mei . . Journal of Kunming Medical University,
[13]	Chai Yan Jing . . Journal of Kunming Medical University,
[14]	Wang Ya Nan . . Journal of Kunming Medical University,
[15]	Tao Hong Fei . . Journal of Kunming Medical University,
[16]	. Evaluation of Atherosclerosis in Rheumatoid Arthritis Patients with High Lipid Levels by Ultrasonography. Journal of Kunming Medical University,
[17]	. Correlation of Life Quality and Coping Styles of Patients with Liver Cancer. Journal of Kunming Medical University,
[18]	. The Amino Acid Metabolism and the Concentration Change of Homocystenine in Hepatitis B Patients. Journal of Kunming Medical University,
[19]	. TRB3 Mediates Homocysteine-induced Inhibition of Endothelial Cells Proliferation. Journal of Kunming Medical University,
[20]	. Association between Serum Homocyteine and Coronary Arteriosclerosis. Journal of Kunming Medical University,