Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People

Li DENG; Hong-li FANG; Guang-qiong CAO; Hui-fang GAO

doi:10.12259/j.issn.2095-610X.S20210107

Volume 42 Issue 1

Jan. 2021

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Li DENG, Hong-li FANG, Guang-qiong CAO, Hui-fang GAO. Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People[J]. Journal of Kunming Medical University, 2021, 42(1): 157-160. doi: 10.12259/j.issn.2095-610X.S20210107

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Li DENG, Hong-li FANG, Guang-qiong CAO, Hui-fang GAO. Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People[J]. Journal of Kunming Medical University, 2021, 42(1): 157-160. doi: 10.12259/j.issn.2095-610X.S20210107

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Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People

doi: 10.12259/j.issn.2095-610X.S20210107

Dept. of Health Management Center，The First Affiliated Hospital of Kumming Medical University，Kunming Yunnan 650032，China

Received Date: 2020-08-12
Available Online: 2021-01-26
Publish Date: 2021-01-26

Abstract

Abstract

Objective To explore the relationship between serum homocysteine（Hcy）and blood lipid in physical examination population and provide the evidence for the mechanism research between Hcy and lipid level. Methods 234 health examinees who came to the health management center of a grade A hospital in Yunnan Province from January 2019 to November 2019 were randomly selected as the subjects. General information, smoking, drinking and diabetes histories of the cases were collected. Plasma homocysteine, blood lipid were measured. Statistical analysis software SPSS 17.0 was used to analyze the level of Hcy and its influencing factors on blood lipid. Results （1）The value of Hcy Md（QR）for males was 12.36（9.90）μmol/L, for females was 7.73（6.40）μmol/L. There was a significant difference between males and females.（2）Smoking history（KW = 15.335, P < 0.001）, drinking history（KW = 18.937, P < 0.001）, LDL-C（r = 0.304, P = 0.002）、TC（r = 0.294, P = 0.003）were all correlated with blood Hcy level. Conclusion Total serum cholesterol（TC）, low density lipoprotein（LDL-C）are all correlated with blood Hcy level. And smoking, drinking and men are also related to the increase of Hcy level. It is necessary to strengthen the monitoring of the level of Hcy in the risky population and do more research about the relationship between Hcy and blood lipid.
- Homocysteine,
- Blood lipid,
- Correlation research

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[1]	赵冬. 新中国成立70年来我国人群血脂流行病学研究回顾与进展[J].中国医药,2019,14(10):1441-1444. doi: 10.3760/j.issn.1673-4777.2019.10.001
[2]	李燕. 同型半胱氨酸与疾病的关系[J].继续医学教育,2020,34(6):79-81. doi: 10.3969/j.issn.1004-6763.2020.06.044
[3]	Antoniades C,Antonopoulos A S,Tousoulis D,et al. Homocysteine and coronary atherosclerosis:from folate fortification to the recent clinical trials[J]. European Heart Journal,2009,30(1):6-15.
[4]	张素华,陈旭虞,陈樱君,等. 家族遗传高脂血症患者血清同型半胱氨酸水平变化及意义[J].山东医药,2018,58(22):74-76. doi: 10.3969/j.issn.1002-266X.2018.22.023
[5]	陈利,余超. 血同型半胱氨酸与高脂血症的相关性研究[J].现代医学与健康研究电子杂志,2018,2(12):75.
[6]	刘国荣,徐永平,陈伟彬. 血浆同型半胱氨酸与颈动脉粥样硬化的相关分析[J].中华老年心脑血管病杂志,2020,22(03):285-287. doi: 10.3969/j.issn.1009-0126.2020.03.016
[7]	吴英浪,路英杰,王晓云. 同型半胱氨酸代谢紊乱对内皮功能障碍影响的研究进展[J].医学综述,2020,26(13):2513-2517,2522. doi: 10.3969/j.issn.1006-2084.2020.13.004
[8]	Peng H,Man C,Xu J,et al. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality:A meta-analysis of prospective studies[J]. Journal of Zhejiang University-Science B,2015,16(1):78-86.
[9]	Veeranna V,Zalawadiya S K,Niraj A,et al. Homocysteine and reclassification of cardiovascular disease risk[J]. Journal of the American College of Cardiology,2011,58(10):1025-1033. doi: 10.1016/j.jacc.2011.05.028
[10]	李敏,刘迎春,李海蓉,等. 东营地区4 109例城乡人群血浆同型半胱氨酸及合并心血管危险因素的调查分析[J].临床神经病学杂志,2017,30(6):439-442. doi: 10.3969/j.issn.1004-1648.2017.06.011
[11]	Takamura N,Abe Y,Nakazato M,et al. Determinants of plasma homecysteine levers and catrotid intima-media thickness in Japanese[J]. Asia Pac J Clin Nutr,2007,16(4):698-703.
[12]	张冰,热比亚·努力,焦谊,等. 870例中青年人群中高同型半胱氨酸血症及其影响因素分析[J].新疆医科大学学报,2019,42(9):1118-1121. doi: 10.3969/j.issn.1009-5551.2019.09.003
[13]	Sakuta H,Suzuki T. Alcohol consumption and plasma homocysteine[J]. Alcohol,2005,37(2):73-77. doi: 10.1016/j.alcohol.2005.12.005
[14]	Lakshman R,Garige M,Gong M,et al. Is alcohol beneficial or harmful for cardioprotection[J]. Genes & Nutrition,2010,5(2):111-120.
[15]	王雅楠,李治纲,张超,等. 同型半胱氨酸通过促进脂肪组织TRB3表达抑制PI3K/Akt信号通路[J].昆明医科大学学报,2017,38(6):15-18. doi: 10.3969/j.issn.1003-4706.2017.06.004
[16]	丛林海,曹光琼,李昕,等. 昆明市中老年人高同型半胱氨酸血症流行状况及其影响因素[J].昆明医科大学学报,2019,40(10):113-116. doi: 10.3969/j.issn.1003-4706.2019.10.025
[17]	王颖,邹永秋,陈泽琨,等. 高同型半胱氨酸血症与血脂异常的相关性研究[J]. 中国动脉硬化杂志,2019,27(10):887-892.
[18]	Momin M,Jia J,Fan F,et al. Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population[J]. Lipids in Health and Disease,2017,16(1):54. doi: 10.1186/s12944-017-0441-6

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