Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy

Jia-mei SONG; Jing-si CHEN; Yu-mei DENG; Zhi-jin HOU; Yu-shi MENG

doi:10.12259/j.issn.2095-610X.S20210124

Volume 42 Issue 1

Jan. 2021

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Jia-mei SONG, Jing-si CHEN, Yu-mei DENG, Zhi-jin HOU, Yu-shi MENG. Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy[J]. Journal of Kunming Medical University, 2021, 42(1): 85-88. doi: 10.12259/j.issn.2095-610X.S20210124

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Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy

doi: 10.12259/j.issn.2095-610X.S20210124

Dept. of Gynaecology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-07-12
Available Online: 2021-01-26
Publish Date: 2021-01-26

Abstract

Abstract

Objective To explore the clinical significance of changes of coagulation tetrad and D-dimer（D-D）and pregnancy outcome in infertile women before and after IVF assisted pregnancy. Methods 115 cases of in vitro fertilization and embryo transfer were collected from June to November 2016 in the Department of Reproductive Medicine, the Second Affiliated Hospital of Kunming Medical University. Four coagulation and DD indexes were detected before and after IVF assisted pregnancy. According to whether the patients were pregnant, they were divided into the pregnancy group（69 cases）and non-pregnancy group（46 cases）. The changes of PT, APTT, FIB, TT and DD before and after IVF assisted pregnancy were compared between the two groups to see if there were any differences. Results The mean values of FIB and DD after IVF assisted pregnancy in pregnancy group were significantly higher than those before IVF assisted pregnancy（3.502±0.773、1.718±1.107 vs 2.875±0.625、0.706±3.101）, while TT was significantly lower than that before IVF assisted pregnancy（3.502±0.773 vs 2.875±0.635）, with significant difference（P < 0.05）; DD after IVF assisted pregnancy in non-pregnancy group was significantly higher than that before IVF assisted pregnancy（2.058±1.507 vs 0.294±0.244）, while TTF was significantly lower. The difference was significant before IVF assisted pregnancy（16.094±0.862 vs 16.830±1.697）（P < 0.05）. There was no significant difference in coagulation and DD between the pregnant group and non-pregnant group before and after IVF（P > 0.05）. Conclusion Detection of PT, APTT, FIB, TT and DD before and after IVF-ET assisted pregnancy in infertile women is helpful to detect abnormal coagulation function in time and improve the success rate of IVF-ET pregnancy in infertile women.
- Infertility,
- IVF,
- Coagulation,
- DD,
- Pregnancy outcome

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