The Correlation between Myocardial Enzymes and the Severity of Ketoacidosis in Children with Type 1 Diabetes

Juan-juan WANG; Yu-qing CHEN; Qian DENG; Jian GAO

doi:10.12259/j.issn.2095-610X.S20210129

Volume 42 Issue 1

Jan. 2021

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Juan-juan WANG, Yu-qing CHEN, Qian DENG, Jian GAO. The Correlation between Myocardial Enzymes and the Severity of Ketoacidosis in Children with Type 1 Diabetes[J]. Journal of Kunming Medical University, 2021, 42(1): 147-151. doi: 10.12259/j.issn.2095-610X.S20210129

Citation:

Juan-juan WANG, Yu-qing CHEN, Qian DENG, Jian GAO. The Correlation between Myocardial Enzymes and the Severity of Ketoacidosis in Children with Type 1 Diabetes[J]. Journal of Kunming Medical University, 2021, 42(1): 147-151. doi: 10.12259/j.issn.2095-610X.S20210129

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The Correlation between Myocardial Enzymes and the Severity of Ketoacidosis in Children with Type 1 Diabetes

doi: 10.12259/j.issn.2095-610X.S20210129

Dept. of Endocrinology，Rheumatology and Immunology，Anhui Provincial Children’s Hospital，Hefei Anhui 230051，China

Received Date: 2020-10-24
Available Online: 2021-01-26
Publish Date: 2021-01-26

Abstract

Abstract

Objective To investigate the correlation between myocardial enzymes and the severity of type 1 diabetic ketoacidosis in children. Methods From January 2016 to December 2019, thirty children with type 1 diabetes and DKA treated in Anhui Provincial Children's Hospital were selected as the research objects, and twenty children with type 1 diabetes and non-DKA during the same period were selected as the control group to analyze the correlation between myocardial enzymes and disease severity. Results The serum levels of LDH, CK, CK-MB and AST in children with DKA were significantly higher than those in the control group（all P < 0.05）. Serum CK, LDH, CK-MB, AST had certain predictive value for DKA in patients with type 1 diabetes, the area under the ROC curve AUC was 0.990（95%CI: 0.969～1.011）, 0.891（95%CI: 0.805～0.977）, 0.843（95%CI: 0.731～0.956）, 0.763（95%CI: 0.622～0.905）. The levels of LDH and CK in children with DKA increased gradually with the progression of the disease（F = 39.251, 11.458; P < 0.001, < 0.001）. Compared with the remission period, the serum levels of LDH, CK, CK-MB and AST in children with DKA increased during the acute phase, and the differences were statistically significant（all P < 0.05）. Multivariate Logistic regression analysis showed that CK and LDH were the independent risk factors for DKA（OR = 1.582, 1.651, P < 0.05）. Spearman correlation analysis showed that CK and LDH were positively correlated with the progression of DKA（r = 0.933, 0.793, P < 0.0001, < 0.0001）. Conclusion As the disease progresses, myocardial enzymes in patients with DKA gradually increase, and dynamic monitoring of changes in myocardial enzymes in patients is of great significance for the disease evaluation and treatment.
- Myocardial enzymes,
- Diabetic ketoacidosis,
- Type 1 diabetes,
- Condition,
- Correlation

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References(16)

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