Changes and Clinical Significance of Serum Cys C, β 2-MG, MCP-1 and Ang Ⅱ Levels in Patients with Chronic Renal Failure

Zhen CHEN; Li-ping GAO

doi:10.12259/j.issn.2095-610X.S20210204

Volume 42 Issue 2

Mar. 2021

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Zhen CHEN, Li-ping GAO. Changes and Clinical Significance of Serum Cys C, β 2-MG, MCP-1 and Ang Ⅱ Levels in Patients with Chronic Renal Failure[J]. Journal of Kunming Medical University, 2021, 42(2): 130-136. doi: 10.12259/j.issn.2095-610X.S20210204

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Zhen CHEN, Li-ping GAO. Changes and Clinical Significance of Serum Cys C, β 2-MG, MCP-1 and Ang Ⅱ Levels in Patients with Chronic Renal Failure[J]. Journal of Kunming Medical University, 2021, 42(2): 130-136. doi: 10.12259/j.issn.2095-610X.S20210204

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Changes and Clinical Significance of Serum Cys C, β 2-MG, MCP-1 and Ang Ⅱ Levels in Patients with Chronic Renal Failure

doi: 10.12259/j.issn.2095-610X.S20210204

Zhen CHEN,
Li-ping GAO^,

Dept. of Renal Rheumatology，Shekou People’s Hospital，Nanshan District，Shenzhen 518067，China

Received Date: 2020-12-07
Publish Date: 2021-03-05

Abstract

Abstract

Objective To investigate the changes of serum cystatin C（Cys C）, β 2-microglobulin（β 2-MG）, monocyte chemoattractant protein-1（MCP-1）and angiotension Ⅱ（ANG Ⅱ）levels in patients with chronic renal failure（CRF）, and analyze the relationship between them and the prognosis of CRF patients. Methods From January 2017 to January 2019, 68 CRF patients（CRF group）and 50 healthy people（control group）were selected from the nephrology department of our hospital. The levels of Cys C, β 2-MG, MCP-1 and ANG Ⅱ in serum were measured, and the differences between the two groups were compared. The end point was all-cause death, the relationship between Cys C, β 2-MG, MCP-1, ANG Ⅱ and the prognosis of CRF patients was analyzed. Results The median follow-up time was 18（13-25）months, 23 cases died（death group）, 50 cases survived（survival group）. The serum levels of CysC, β 2-MG, MCP-1 and ANG Ⅱ in the death group were higher than those in the survival group and the control group（P < 0.05）. The levels of CysC, β 2-MG, MCP-1 and ANG Ⅱ in CRF patients increased with the increase of CKD grading（P < 0.05）. Serum CysC, β 2-MG, MCP-1, ANG Ⅱwere negatively correlated with estimated glomerular filtration rate（EGFR）（r = -0.435, -0.406, -0.621, -0.594, P < 0.05）, and positively correlated with urinary albumin / creatinine ratio（ACR）（r = 0.406, 0.435, 0.562, 0.503, P < 0.05）. ROC analysis showed that AUC of CysC, β 2-MG, MCP-1 and ANG Ⅱ were 0.681（95% CI: 0.551-0.811）, 0.649（95% CI: 0.510-0.789）, 0.917（95% CI: 0.852-0.981）and 0.838（95% CI: 0.733-0.942）, respectively. Kaplan-Meier survival analysis showed that the survival time of high level CysC, β 2-MG, MCP-1, ANG Ⅱ group was shorter than that of low level CysC, β 2-MG, MCP-1, ANG Ⅱ group（P < 0.05）. Multivariate Cox regression analysis showed high levels of CysC, β 2-MG, MCP-1 and ANG Ⅱ were independent risk factors for all-cause death of CRF（P < 0.001）. Conclusion The serum levels of CysC, β 2-MG, MCP-1 and ANG Ⅱ are closely related to the degree of renal injury and poor prognosis in CRF patients, which can be used as an auxiliary index for the prognosis evaluation of CRF.
- Chronic renal failure,
- Cys C,
- β 2-MG,
- MCP-1,
- ANG Ⅱ,
- All cause death

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