Research Progress on Neurotoxic Effects and Mechanism of Methamphetamine

Yuan-yuan LI; Juan LI; Gen-meng YANG; Jian HUANG; Liu LIU; Bao-yu SHEN; Chan WANG; Yue XU; Shu-cheng LIN; Xiao-feng ZENG

doi:10.12259/j.issn.2095-610X.S20210210

Volume 42 Issue 2

Mar. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(2): 153-157

Yuan-yuan LI, Juan LI, Gen-meng YANG, Jian HUANG, Liu LIU, Bao-yu SHEN, Chan WANG, Yue XU, Shu-cheng LIN, Xiao-feng ZENG. Research Progress on Neurotoxic Effects and Mechanism of Methamphetamine[J]. Journal of Kunming Medical University, 2021, 42(2): 153-157. doi: 10.12259/j.issn.2095-610X.S20210210

Citation:

Yuan-yuan LI, Juan LI, Gen-meng YANG, Jian HUANG, Liu LIU, Bao-yu SHEN, Chan WANG, Yue XU, Shu-cheng LIN, Xiao-feng ZENG. Research Progress on Neurotoxic Effects and Mechanism of Methamphetamine[J]. Journal of Kunming Medical University, 2021, 42(2): 153-157. doi: 10.12259/j.issn.2095-610X.S20210210

Citation:

Yuan-yuan LI, Juan LI, Gen-meng YANG, Jian HUANG, Liu LIU, Bao-yu SHEN, Chan WANG, Yue XU, Shu-cheng LIN, Xiao-feng ZENG. Research Progress on Neurotoxic Effects and Mechanism of Methamphetamine[J]. Journal of Kunming Medical University, 2021, 42(2): 153-157. doi: 10.12259/j.issn.2095-610X.S20210210

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Research Progress on Neurotoxic Effects and Mechanism of Methamphetamine

doi: 10.12259/j.issn.2095-610X.S20210210

1.
Dept. of Forensic Pathology and Clinical Medicine，School of Forensic Medicine
2.
Dept. of Pathogenic Biology and Immunology，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-12-05
Publish Date: 2021-03-05

Abstract

Abstract

Methamphetamine is a serious threat to public health and safety of mental excitatory drugs. Long-term abuse of METH will cause obvious neuronal injury and neurotoxicity. Oxidative stress, mitochondrial metabolic damage and neuroinflammation play important roles in meth-induced neuronal injury. In this paper, we reviewed the mechanism of neuronal injury induced by METH and the neurotoxicity mechanism of METH. The neuroinflammatory effect of reactive glial cells is described in detail, and the neuroinflammatory drugs induced by targeted METH are summarized. This article aims to further explore the mechanism of meth-induced neurotoxicity and provide new ideas for inhibiting meth neurotoxicity and drug development.
- Methamphetamine,
- Neurotoxicity,
- Neuroinflammation,
- Reactive gliosis

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References(30)

References

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