Clinical Significance of Anti-dsDNA Antibody，Complement C3 and Other Laboratory Indicators in the Diagnosis of Renal Injury in Systemic Lupus Erythematosus

Xue LOU; Li LIAO; Ruo-tong ZHAO; Xiang-yu WANG; Yi-fan YANG; Shuang LIU; Jian XU

doi:10.12259/j.issn.2095-610X.S20210214

Volume 42 Issue 2

Mar. 2021

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Xue LOU, Li LIAO, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan YANG, Shuang LIU, Jian XU. Clinical Significance of Anti-dsDNA Antibody，Complement C3 and Other Laboratory Indicators in the Diagnosis of Renal Injury in Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2021, 42(2): 49-53. doi: 10.12259/j.issn.2095-610X.S20210214

Citation:

Xue LOU, Li LIAO, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan YANG, Shuang LIU, Jian XU. Clinical Significance of Anti-dsDNA Antibody，Complement C3 and Other Laboratory Indicators in the Diagnosis of Renal Injury in Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2021, 42(2): 49-53. doi: 10.12259/j.issn.2095-610X.S20210214

Citation:

Xue LOU, Li LIAO, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan YANG, Shuang LIU, Jian XU. Clinical Significance of Anti-dsDNA Antibody，Complement C3 and Other Laboratory Indicators in the Diagnosis of Renal Injury in Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2021, 42(2): 49-53. doi: 10.12259/j.issn.2095-610X.S20210214

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Clinical Significance of Anti-dsDNA Antibody，Complement C3 and Other Laboratory Indicators in the Diagnosis of Renal Injury in Systemic Lupus Erythematosus

doi: 10.12259/j.issn.2095-610X.S20210214

Dept. of Rheumatology and Immunology，The First Affiliated Hospital of Kunming Medical University，Kunming Yunan 650032，China

Received Date: 2020-11-04
Publish Date: 2021-03-05

Abstract

Abstract

Objective To investigate the clinical application value of anti-dsDNA antibody, complement C3 and other laboratory indicators in patients with systemic lupus erythematosus （SLE） with renal injury. Methods The clinical data of 296 SLE patients were retrospectively analyzed. The differences of autoantibodies and other laboratory indicators between SLE with renal injury group and without renal injury group were compared, and the immunological indicators of SLE renal injury were found. Results The positive rates of serum anti-dsDNA, anti-nucleosome and anti-histone antibodies in SLE with renal injury group were significantly higher than those in without renal injury group, serum renal function indexes such as urea, creatinine and uric acid, electrolytes such as potassium, chlorine and calcium ion were significantly higher than those in without renal injury group, and the levels of immunoglobulin IgG, IgA and complement C3 were significantly lower than those in without renal injury group （P < 0.05）. Conclusion Anti-dsDNA, anti-nucleosome, anti-histone autoantibodies, complement C3 and other laboratory indicators may be associated with renal injury in SLE patients.
- Systemic lupus erythematosus,
- Renal injury,
- Autoantibody,
- Anti-dsDNA antibody,
- C3

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References(21)

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