Effect of Renal Sympathetic Denervation on Renin Activity and Ventricular Remodeling in Spontaneously Hypertensive Rats in Acute Stage

Si-ming TAO; Yun-yu CHEN; Rong WEI; Ming-hua HAN

doi:10.12259/j.issn.2095-610X.S20210218

Volume 42 Issue 2

Mar. 2021

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Si-ming TAO, Yun-yu CHEN, Rong WEI, Ming-hua HAN. Effect of Renal Sympathetic Denervation on Renin Activity and Ventricular Remodeling in Spontaneously Hypertensive Rats in Acute Stage[J]. Journal of Kunming Medical University, 2021, 42(2): 96-102. doi: 10.12259/j.issn.2095-610X.S20210218

Citation:

Si-ming TAO, Yun-yu CHEN, Rong WEI, Ming-hua HAN. Effect of Renal Sympathetic Denervation on Renin Activity and Ventricular Remodeling in Spontaneously Hypertensive Rats in Acute Stage[J]. Journal of Kunming Medical University, 2021, 42(2): 96-102. doi: 10.12259/j.issn.2095-610X.S20210218

Citation:

Si-ming TAO, Yun-yu CHEN, Rong WEI, Ming-hua HAN. Effect of Renal Sympathetic Denervation on Renin Activity and Ventricular Remodeling in Spontaneously Hypertensive Rats in Acute Stage[J]. Journal of Kunming Medical University, 2021, 42(2): 96-102. doi: 10.12259/j.issn.2095-610X.S20210218

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Effect of Renal Sympathetic Denervation on Renin Activity and Ventricular Remodeling in Spontaneously Hypertensive Rats in Acute Stage

doi: 10.12259/j.issn.2095-610X.S20210218

Dept. of Cardiovascular Diseases，The Second People’s Hospital of Yunnan Province，Kunming Yunnan 650021，China

Received Date: 2020-11-03
Publish Date: 2021-03-05

Abstract

Abstract

Objectives To observe the effect of renal sympathetic denervation on acute ventricular remodeling in SHR. Methods This experiment enrolled 50 male rats of SHR, the average weight was （265±12） g. According to the difference of intervention way, they were randomly divided into operation intervention group（M） and blank control group（B）. The group M were divided into groups of Left, Right, Dual and Sham-operation randomly again. Five rats of WKY were enrolled as negative control group. The blood pressure, weight and the activity of plasma renin were measured for all rats. The mode of Renal Sympathetic Denervation was made by operation. After operation, they were executed and and their hearts and kidney tissues were collected. The index of weight of body and heart, HW/BW, thickness of ventricular tissue and its histopathology were collected and analyzed, while, the level of RAAS factors were dectected in circulation and tissue. Results There were statistically significant differences among group B and S with group M（P < 0.05）, including HW/BW, cardiac muscle cell hypertrophy, interstitial edema and fibrosis under the microscope. The concentration of factors, including AngⅠ, AngⅡ, ALD and NA, were down regulated in circulation and tissue, and there were statistically significant differences between operation with control group respectively. Conclusions Renal sympathetic denervation has significant alleviation effect on acute ventricular remodeling in SHR. These effect maybe come from decreasing the level of factor related with RAAS.
- Renal sympathetic denervation,
- Spontaneously hypertensive rats,
- Ventricular remodeling

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References(16)

References

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