Effects of Dexmedetomidine on the Incidence of Emergence Delirium after General Anesthesia in Pediatric Patients Undergoing Hip Surgery

Yun-li YANG; Na LI; Heng LI; Jun-zhen SHI; Zhi-gui LI

doi:10.12259/j.issn.2095-610X.S20210223

Volume 42 Issue 2

Mar. 2021

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Yun-li YANG, Na LI, Heng LI, Jun-zhen SHI, Zhi-gui LI. Effects of Dexmedetomidine on the Incidence of Emergence Delirium after General Anesthesia in Pediatric Patients Undergoing Hip Surgery[J]. Journal of Kunming Medical University, 2021, 42(2): 108-112. doi: 10.12259/j.issn.2095-610X.S20210223

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Effects of Dexmedetomidine on the Incidence of Emergence Delirium after General Anesthesia in Pediatric Patients Undergoing Hip Surgery

doi: 10.12259/j.issn.2095-610X.S20210223

Dept. of Anesthesiology，920th Hospital of Joint Logistics Support Force，PLA，Kunming Yunnan 650032，China

Received Date: 2020-12-08
Publish Date: 2021-03-05

Abstract

Abstract

Objective To evaluate the effect of continuous infusions of dexmedetomidine on the pediatric anesthesia emergence delirium （PAED）after general anesthesia in pediatric patients undergoing hip surgery. Methods Seventy children, ASA class I-II, aged 3～6 years scheduled for elective hip surgery under general anesthesia. The patients were randomly assigned to two groups. The dexmedetomidine group （group D, n = 35）, which received dexmedetomidine infusion at a rate of 0.3 μg/（kg·h） after induction of anesthesia until to 30 minutes before the end of surgery and the control group （group C, n = 35）, which received a volume-matched normal saline infusion as a placebo at the same time. All children were sent to the PACU after extubation. The primary outcome was the incidence of paedED and pain within 30 minutes after extubation. The scale of pain and paedED were recorded at 10, 20, 30, 60 minutes and 24h after extubation. In addition, the extubation time, the incidence of requiring rescue analgesic and the satisfaction scale of nurse were recorded as well. Results Compared with the Group C, the incidence of pain and the paediatric emergence delirium （PaedED）were significantly decreased respectively in group D （48.6% vs 22.9%; P < 0.01; 62.9% vs 37.1% P < 0.05）, but extubation time was prolonged （ P < 0.05）. The satisfaction scale of nurse was significantly higher and the incidence of requiring rescue analgesic was significantly lower in Group D than it was in Group C during PACU （ P < 0.05, respectively）. There was no statistically significant difference between the pain score and the PAED score at 24 hours after surgery. Conclusion Continuous infusions of dexmedetomidine 0.3 μg/（kg·h）can reduce the incidence of paedED after general anesthesia in pediatric patients undergoing hip surgery.
- Dexmedetomidine,
- PAED,
- Hip surgery,
- Children

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References

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