Effects of Dexmedetomidine on the Incidence of Emergence Delirium after General Anesthesia in Pediatric Patients Undergoing Hip Surgery

Yun-li YANG; Na LI; Heng LI; Jun-zhen SHI; Zhi-gui LI

doi:10.12259/j.issn.2095-610X.S20210223

Volume 42 Issue 2

Mar. 2021

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Yun-li YANG, Na LI, Heng LI, Jun-zhen SHI, Zhi-gui LI. Effects of Dexmedetomidine on the Incidence of Emergence Delirium after General Anesthesia in Pediatric Patients Undergoing Hip Surgery[J]. Journal of Kunming Medical University, 2021, 42(2): 108-112. doi: 10.12259/j.issn.2095-610X.S20210223

Citation:

Yun-li YANG, Na LI, Heng LI, Jun-zhen SHI, Zhi-gui LI. Effects of Dexmedetomidine on the Incidence of Emergence Delirium after General Anesthesia in Pediatric Patients Undergoing Hip Surgery[J]. Journal of Kunming Medical University, 2021, 42(2): 108-112. doi: 10.12259/j.issn.2095-610X.S20210223

Citation:

Yun-li YANG, Na LI, Heng LI, Jun-zhen SHI, Zhi-gui LI. Effects of Dexmedetomidine on the Incidence of Emergence Delirium after General Anesthesia in Pediatric Patients Undergoing Hip Surgery[J]. Journal of Kunming Medical University, 2021, 42(2): 108-112. doi: 10.12259/j.issn.2095-610X.S20210223

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Effects of Dexmedetomidine on the Incidence of Emergence Delirium after General Anesthesia in Pediatric Patients Undergoing Hip Surgery

doi: 10.12259/j.issn.2095-610X.S20210223

Dept. of Anesthesiology，920th Hospital of Joint Logistics Support Force，PLA，Kunming Yunnan 650032，China

Received Date: 2020-12-08
Publish Date: 2021-03-05

Abstract

Abstract

Objective To evaluate the effect of continuous infusions of dexmedetomidine on the pediatric anesthesia emergence delirium （PAED）after general anesthesia in pediatric patients undergoing hip surgery. Methods Seventy children, ASA class I-II, aged 3～6 years scheduled for elective hip surgery under general anesthesia. The patients were randomly assigned to two groups. The dexmedetomidine group （group D, n = 35）, which received dexmedetomidine infusion at a rate of 0.3 μg/（kg·h） after induction of anesthesia until to 30 minutes before the end of surgery and the control group （group C, n = 35）, which received a volume-matched normal saline infusion as a placebo at the same time. All children were sent to the PACU after extubation. The primary outcome was the incidence of paedED and pain within 30 minutes after extubation. The scale of pain and paedED were recorded at 10, 20, 30, 60 minutes and 24h after extubation. In addition, the extubation time, the incidence of requiring rescue analgesic and the satisfaction scale of nurse were recorded as well. Results Compared with the Group C, the incidence of pain and the paediatric emergence delirium （PaedED）were significantly decreased respectively in group D （48.6% vs 22.9%; P < 0.01; 62.9% vs 37.1% P < 0.05）, but extubation time was prolonged （ P < 0.05）. The satisfaction scale of nurse was significantly higher and the incidence of requiring rescue analgesic was significantly lower in Group D than it was in Group C during PACU （ P < 0.05, respectively）. There was no statistically significant difference between the pain score and the PAED score at 24 hours after surgery. Conclusion Continuous infusions of dexmedetomidine 0.3 μg/（kg·h）can reduce the incidence of paedED after general anesthesia in pediatric patients undergoing hip surgery.
- Dexmedetomidine,
- PAED,
- Hip surgery,
- Children

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References(12)

References

[1]	Cesar A,Gabriella B,Federico B,et al. European society of anaesthesiology evidence-based and consensus-based guideline on postoperative delirium[J]. Eur J Anaesthesiol,2017,34(4):192-214. doi: 10.1097/EJA.0000000000000594
[2]	Dahmani S,Stany I,Brasher C,et al. Pharmacological prevention of sevoflurane and desflurane related emergence agitation in children:a meta-analysis of published studies[J]. Br J Anaesth,2010,104(2):216-223. doi: 10.1093/bja/aep376
[3]	刘进, 邓小明. 中国麻醉学指南与专家共识[M]. 北京: 人民卫生出版社, 2014.: 283.
[4]	Dahmani S,Delivet H,Hilly J,et al. Emergence delirium in children:An update[J]. Current Opinion in Anaesthesiology,2014,27(3):309-315. doi: 10.1097/ACO.0000000000000076
[5]	Wong D D L,Bailey C R. Emergence delirium in children[J]. Anaesthesia,2015,70(4):383-387. doi: 10.1111/anae.13043
[6]	Neufeld K J,Leoutsakos J M,Sieber F E,et al. Outcomes of early delirium diagnosis after general anesthesia in the elderly[J]. Anesth Analg,2013,117(2):471-478. doi: 10.1213/ANE.0b013e3182973650
[7]	杨云丽,罗晓东,张承华,等. 右美托咪啶对青少年特发性脊柱侧弯矫形术后谵妄的影响[J]. 昆明医科大学学报,2013,24(12):33-36.
[8]	杨云丽,张承华,邓玫,等. 右美托咪啶对老年手术患者血清S-100β蛋白、NSE浓度的影响[J]. 昆明医科大学学报,2016,37(7):58-61. doi: 10.3969/j.issn.1003-4706.2016.07.014
[9]	Shukry M,Clyde M C,Kalarickal P L,et al. Does dexmedeto- midine prevent emergence delirium in children after sevoflurane-based general anesthesia[J]. Paediatr Anaesth,2010,15(12):1098-1104.
[10]	Jun-Li Cao,Yu-Ping Pei,Jing-Qiu Wei,et al. Effects of intraoperative dexmedetomidine with intravenous anesthesia on postoperative emergence agitation/delirium in pediatric patients undergoing tonsillectomy with or without adenoidectomy:a CONSORT-prospective,randomized,controlled clinical trial[J]. Medicine,2016,95(49):e5566. doi: 10.1097/MD.0000000000005566
[11]	赵紫健,曹君利. 患者全身麻醉苏醒期谵妄的研究进展[J]. 临床麻醉学杂志,2018,34(11):94-97.
[12]	Bong C L,Lim E,Allen J C,et al. A comparison of single-dose dexmedetomidine or propofol on the incidence of emergence delirium in children undergoing general anaesthesia for magnetic resonance imaging[J]. Anaesthesia,2015,70(4):393-399. doi: 10.1111/anae.12867

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