Application Value of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Diagnosis of Space-occupying Lesions of Lung and Mediastinum

Lu YAO; Hui TAN; Yong-hua RUAN; Zhong-yi QIAN; Zhi-hong YANG; Rui RUAN; Qi-ying ZHANG; Ming-ting ZHOU; Xing-yin FANG

doi:10.12259/j.issn.2095-610X.S20210311

Volume 42 Issue 3

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 41-48

Lu YAO, Hui TAN, Yong-hua RUAN, Zhong-yi QIAN, Zhi-hong YANG, Rui RUAN, Qi-ying ZHANG, Ming-ting ZHOU, Xing-yin FANG. Application Value of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Diagnosis of Space-occupying Lesions of Lung and Mediastinum[J]. Journal of Kunming Medical University, 2021, 42(3): 41-48. doi: 10.12259/j.issn.2095-610X.S20210311

Citation:

Lu YAO, Hui TAN, Yong-hua RUAN, Zhong-yi QIAN, Zhi-hong YANG, Rui RUAN, Qi-ying ZHANG, Ming-ting ZHOU, Xing-yin FANG. Application Value of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Diagnosis of Space-occupying Lesions of Lung and Mediastinum[J]. Journal of Kunming Medical University, 2021, 42(3): 41-48. doi: 10.12259/j.issn.2095-610X.S20210311

Citation:

Lu YAO, Hui TAN, Yong-hua RUAN, Zhong-yi QIAN, Zhi-hong YANG, Rui RUAN, Qi-ying ZHANG, Ming-ting ZHOU, Xing-yin FANG. Application Value of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Diagnosis of Space-occupying Lesions of Lung and Mediastinum[J]. Journal of Kunming Medical University, 2021, 42(3): 41-48. doi: 10.12259/j.issn.2095-610X.S20210311

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Application Value of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Diagnosis of Space-occupying Lesions of Lung and Mediastinum

doi: 10.12259/j.issn.2095-610X.S20210311

1.
Dept. of Pathology
2.
Clinical Skills Center，Kunming Medical University，Kunming Yunnan 650500
3.
First Department of Thoracic Surgery，The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Hospital，Kunming Yunnan 650118
4.
Dept. of Orthopedics，The First Affiliated Hospital，Kunming Medical University，Kunming Yunnan 650032
5.
Grade 2015 Clinical Medicine Major，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-12-27
Publish Date: 2021-04-09

Abstract

Abstract

Objective To investigate the value of transbronchial needle aspiration biopsy （EBUS-TBNA） guided by ultrasound bronchoscope in the diagnosis of lung and mediastinal space-occupying lesions and staging of lung cancer. Methods Ninety patients with space-occupying lesions of lung and mediastinum underwent transbronchial needle aspiration biopsy guided by ultrasound bronchoscope. 151 specimens were embedded in paraffin, stained with HE, and diagnosed by cytopathology. Ki67 was detected by immunocytochemistry. Lymph node staging was performed for lung cancer. The coincidence rate and sensitivity of cytological diagnosis were analyzed according to the criteria of histopathological diagnosis combined with clinical diagnosis. Results The success rate of EBUS-TBNA puncture was 100% （151/151）, and the success rate of diagnosis was 91.1% （82/90）. The diagnostic rate of lung and mediastinal space-occupying lesions after EBUS-TBNA was significantly increased （P < 0.01）.Among 90 cases, malignant tumors accounted for 72.22% （65/90）, benign lesions accounted for 18.89% （17/90）, and 8.89% had no definite diagnosis （8/90）. 57 cases of malignant cells were found by cytology. The sensitivity of cytopathological diagnosis was 87.69%. TNM staging was achieved in 80% of lung cancers （44/55）. Ki67 positive index of pulmonary tuberculosis and granulomatous inflammation was 0-3%. The positive index of Ki67 in malignant pulmonary nodules ranged from 20% to 80%. There was significant difference in Ki67 expression between benign and malignant lung lesions （P < 0.01）. Conclusions EBUS-TBNA is a safe, sensitive and accurate diagnostic method, which can significantly improve the diagnostic success rate of lung and mediastinal space-occupying lesions. It has important guiding significance and clinical application value for the classification, staging, treatment and prognosis of lung cancer. Ki67 positive index is an important reference index for judging the benign and malignant of EBUS-TBNA puncture cells.
- EBUS-TBNA,
- Lung cancer,
- Lung nodule,
- Tuberculosis,
- Sarcoidosis,
- Cytology,
- Ki-67

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References(16)

References

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