Effect of Hyperhomocysteinemia on Cardiac Function and Mortality of Patients with Acute Myocardial Infarction Concomitant Hypertension underwent Primary Percutaneous Coronary Intervention after 6 Months

Hai-ping ZHANG; Shu-juan YANG; Li-xia YANG; Zhao-juan RUAN; Rui-wei GUO

doi:10.12259/j.issn.2095-610X.S20210319

Volume 42 Issue 3

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 73-78

Hai-ping ZHANG, Shu-juan YANG, Li-xia YANG, Zhao-juan RUAN, Rui-wei GUO. Effect of Hyperhomocysteinemia on Cardiac Function and Mortality of Patients with Acute Myocardial Infarction Concomitant Hypertension underwent Primary Percutaneous Coronary Intervention after 6 Months[J]. Journal of Kunming Medical University, 2021, 42(3): 73-78. doi: 10.12259/j.issn.2095-610X.S20210319

Citation:

Hai-ping ZHANG, Shu-juan YANG, Li-xia YANG, Zhao-juan RUAN, Rui-wei GUO. Effect of Hyperhomocysteinemia on Cardiac Function and Mortality of Patients with Acute Myocardial Infarction Concomitant Hypertension underwent Primary Percutaneous Coronary Intervention after 6 Months[J]. Journal of Kunming Medical University, 2021, 42(3): 73-78. doi: 10.12259/j.issn.2095-610X.S20210319

Citation:

Hai-ping ZHANG, Shu-juan YANG, Li-xia YANG, Zhao-juan RUAN, Rui-wei GUO. Effect of Hyperhomocysteinemia on Cardiac Function and Mortality of Patients with Acute Myocardial Infarction Concomitant Hypertension underwent Primary Percutaneous Coronary Intervention after 6 Months[J]. Journal of Kunming Medical University, 2021, 42(3): 73-78. doi: 10.12259/j.issn.2095-610X.S20210319

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Effect of Hyperhomocysteinemia on Cardiac Function and Mortality of Patients with Acute Myocardial Infarction Concomitant Hypertension underwent Primary Percutaneous Coronary Intervention after 6 Months

doi: 10.12259/j.issn.2095-610X.S20210319

1.
Dept. of Cardiology，Kunming Medical University，920th Hospital of Joint Logistics Support Force- teaching Hospital
2.
Dept. of Cardiology
3.
Dept. of Endocrinology，920th Hospital of Joint Logistics Support Force，Kunming Yunnan 650032，China

Received Date: 2020-12-06
Publish Date: 2021-04-09

Abstract

Abstract

Objective To identify the effect of hyperhomocysteinemia on cardiac function and mortality in patients with acute ST-segment elevation myocardial infarction concomitant hypertension underwent primary PCI after 6 months. Methods 192 patients in the Department of Cardiology, 920th Hospital of Joint Logistics Support Force with acute ST-segment elevation myocardial infarction concomitant hypertension who had undergone primary PCI was recruited from June 2015 to December 2016. 116 cases were excluded from the study owing to their incomplete follow-up data .The total remaining 78 patients were divided into two groups according to the level of homocysteine （Hcy） ≥15.0 mol/L: STEMI combined with H-type hypertension group （n = 39） and the STEMI combined with hypertension group （n = 38）. Baseline data of the two groups, relevant data during hospitalization and PCI, and left ventricular ejection fraction and cumulative mortality 6 months after surgery were compared. Results There were statistically significant differences in male proportion, serum creatinine and HCY between the two groups （P < 0.05）. There was statistically significant difference in the number of lesion vessels which was higher in the high Hcy group than in the control group （P < 0.012）. No statistically significant difference was showed in left ventricular ejection fraction at the time of hospitalization and the 6th month, the difference value between two left ventricular ejection fractions and the cumulative death at the 6th month between the two groups （all P > 0.05）. Conclusion Hyperhomocysteine has no effect on cardiac function and cumulative mortality 6 months after primary PCI in patients with acute ST-segment elevation myocardial infarction concomitant hypertension.
- Hyperhomocysteinemia,
- ST-segment elevated myocardial infarction,
- Hypertension,
- Percutaneous coronary intervention,
- Cardiac function,
- Mortality

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References(18)

References

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