Efficacy and Safety of Sofosbuvir/Vipatavir Combined with Ribavirin in Treatment of Genotype 3 Patients with Chronic Hepatitis C

Zhi-rong ZHAO; Hai-wen LI; Xiao-fei LI; Ni-hong LU; Yong-rui YANG

doi:10.12259/j.issn.2095-610X.S20210325

Volume 42 Issue 3

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 98-103

Zhi-rong ZHAO, Hai-wen LI, Xiao-fei LI, Ni-hong LU, Yong-rui YANG. Efficacy and Safety of Sofosbuvir/Vipatavir Combined with Ribavirin in Treatment of Genotype 3 Patients with Chronic Hepatitis C[J]. Journal of Kunming Medical University, 2021, 42(3): 98-103. doi: 10.12259/j.issn.2095-610X.S20210325

Citation:

Zhi-rong ZHAO, Hai-wen LI, Xiao-fei LI, Ni-hong LU, Yong-rui YANG. Efficacy and Safety of Sofosbuvir/Vipatavir Combined with Ribavirin in Treatment of Genotype 3 Patients with Chronic Hepatitis C[J]. Journal of Kunming Medical University, 2021, 42(3): 98-103. doi: 10.12259/j.issn.2095-610X.S20210325

Citation:

Zhi-rong ZHAO, Hai-wen LI, Xiao-fei LI, Ni-hong LU, Yong-rui YANG. Efficacy and Safety of Sofosbuvir/Vipatavir Combined with Ribavirin in Treatment of Genotype 3 Patients with Chronic Hepatitis C[J]. Journal of Kunming Medical University, 2021, 42(3): 98-103. doi: 10.12259/j.issn.2095-610X.S20210325

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Efficacy and Safety of Sofosbuvir/Vipatavir Combined with Ribavirin in Treatment of Genotype 3 Patients with Chronic Hepatitis C

doi: 10.12259/j.issn.2095-610X.S20210325

Zhi-rong ZHAO^{1, 2},
Hai-wen LI¹,
Xiao-fei LI¹,
Ni-hong LU^{1
,
,},
Yong-rui YANG^{1
,
,}

1.
Dept. of Hepatology，The 3rd People’s Hospital of Kunming Yunnan Provincial Center for Infectious Diseases Clinical Medicine），Kunming Yunnan 650041
2.
School of Public Health，Dali University，Kunming Yunnan 671000，China

Received Date: 2020-12-01
Publish Date: 2021-04-09

Abstract

Abstract

Objective To observe the efficacy and safety of combined with Ribavirin （SOF/VEL+RBV） in the treatment of genotype-3 patients with chronic hepatitis C. Methods We selected 80 genotype-3, and newly treated chronic hepatitis C patients, who were admitted to the Department of Liver Diseases, Kunming Third People's Hospital, and divided them into 2 groups. The combined treatment group, containing 40 patients, was treated with the antiviral therapy that combines Sofosbuvir/Velpatasvir and Ribavirin （SOF/VEL + RBV）. The control group was 40 patients that were adopted with a single-agent antiviral treatment of Sofosbuvir/Velpatasvir. All patients were monitored with their continuous virological response, the changes in biochemical indicators and Fibroscan indicators during the treatment of 4 and 12 weeks as well as an additional 12 weeks after stopping the therapy. Results The combined treatment group showed their SVR rate at the 4^th and 12^th week were 90.00%, 70.00% and 97.50%, 80.00%, respectively and reached 97.50%, 80.00%, at 12^th week after the termination of the treatment. The patients' serum biochemical indicators such as ALT, AST, GGT, and ALB decreased more significantly than the patients in the single-agent group （P < 0.05） and there was no significant difference between the two groups at the 12-week follow-up after the treatment termination （P > 0.05）. For the single-agent group, at the 12th week after the treatment the Fibroscan value decrease significantly （F = 5.700, P = 0.018） and at 12th-week follow-up after the treatment termination there was no difference in Fibroscan values between the two groups （F = 0.012, P = 0.912）. During the period of the treatment time, the adverse reactions from both groups were mainly fatigue, headache and dizziness. Conclusions For genotype-3 patients with newly treated chronic hepatitis C, the combined treatment of Sofosbuvir/Velpatasvir and Ribavirin （SOF/VEL + RBV） can have higher SVR rate and biochemical response rate, better efffect on improving liver fibrosis with better safety than single-agent treatment of Sofosbuvir/Velpatasvir.
- Chronic hepatitis C,
- Sofosbuvir/Velpatasvir,
- Efficacy; Safety

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