Correlation of Adult Urine Iodine Level and Thyroid Disease

Fang LIU; Xi-bing ZHANG; Ling NIU; Rong MA; Bo-yi LI

doi:10.12259/j.issn.2095-610X.S20210326

Volume 42 Issue 3

Apr. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 104-108

Fang LIU, Xi-bing ZHANG, Ling NIU, Rong MA, Bo-yi LI. Correlation of Adult Urine Iodine Level and Thyroid Disease[J]. Journal of Kunming Medical University, 2021, 42(3): 104-108. doi: 10.12259/j.issn.2095-610X.S20210326

Citation:

Fang LIU, Xi-bing ZHANG, Ling NIU, Rong MA, Bo-yi LI. Correlation of Adult Urine Iodine Level and Thyroid Disease[J]. Journal of Kunming Medical University, 2021, 42(3): 104-108. doi: 10.12259/j.issn.2095-610X.S20210326

Citation:

PDF( 579 KB)

Correlation of Adult Urine Iodine Level and Thyroid Disease

doi: 10.12259/j.issn.2095-610X.S20210326

1.
Dept. of Endocrine，The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming，Kunming Yunnan 650224
2.
Dept. of Hepatopancreatobiliary Surgery，The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming，Kunming Yunnan 650224，China

Received Date: 2020-12-19
Publish Date: 2021-03-25

Abstract

Abstract

Objective To understand the relationship between the distribution of urinary iodine level and thyroid diseases in adults in kunming, and to provide scientific basis for iodine supplementation in thyroid patients in this region. Method In this prospective study, 207 patients with thyroid diseases who were admitted to the department of endocrinology and outpatient department of the affiliated calmette hospital of kunming medical university from January to December 2018 were included as the case group, and were divided into hashimoto thyroiditis group, hyperthyroidism group, hypothyroidism group, and thyroid nodule group. At the same time, 59 healthy patients in the outpatient department were selected as the control group. Groups are used arsenic cerium catalytic spectrophotometry determination of urine iodine, and application of chemiluminescence immunoassay technology to three iodine determination of serum free thyroid glycine （FT3） and free thyroid hormone （FT4）, thyroid stimulating factor （TSH）, thyroid peroxidase antibody （TPOAb）, thyroglobulin antibody （TgAb）, the case group and the control group were performed thyroid ultrasound, and according to the test results, statistical analysis was carried out on the different urine iodine level of thyroid disease. Results （1） For patients in hashimoto thyroiditis and thyroid function hyperfunction group, hypothyroidism and thyroid nodule group and control group, the median of urinary iodine was 177.4 g/L , 171.6 g/L, 105.2 g/L, 151.3 g/L and 178.3 g/L, respectively. The median of hypothyroidism group was significantly lower than normal group, the difference was statistically significant （P < 0.05）, there was no statistically significant difference between other groups （ P > 0.05）. （2） A high proportion of high and low iodine was found in each thyroid disease group. （3） There was no statistical significance between different groups in the urinary iodine levels and FT3, FT4, TSH, TPOAb and TgAb （ P > 0.05）. Conclusion The iodine nutrition of adults in Kunming is at a sufficient level, and the supplement of iodine should be individualized, scientific and reasonable. There is a correlation between low urinary iodine and thyroid diseases. Insufficient iodine intake can promote the high incidence of thyroid diseases.
- Urine iodine,
- Thyroid,
- Hashimoto thyroiditis,
- Hypothyroidism,
- Thyroid nodule

FullText(HTML)

References(21)

References

[1]	Hetzel B S. Iodine deficiency disorders (IDD) and their eradication[J]. Lancet,1983,2(8359):1126-1129.
[2]	Khuen B. Iodine deficiency may impair fertility[J]. Jama,2018,319(8):760.
[3]	阎玉芹. 保证全民适宜的碘营养是碘缺乏病防治工作的长期任务[J]. 中国地方病学杂志,2005,24(3):237-238.
[4]	Song J,Zou S R,Guo C Y,et al. Prevalence of thyroid nodules and its relationship with iodine status in Shanghai:a population-based study[J]. Biomed Environ Sci,2016,29(6):398-407.
[5]	WS/T107-2006, 尿中碘的砷铈催化分光光度法[S]. 北京: 中华人民共和国卫生部, 2006.
[6]	WHO/UNICEF/ICCIDD. Assessment of the iodine deficiency disorders and monitoring their elimination: a guide for programme managers[R]. Geneva: WHO, 2007: 32-34.
[7]	中华医学会内分泌学分会. 成人甲状腺功能减退症诊治指南(2017)[J]. 中华内分泌代谢杂志,2017,33(2):167-180. doi: 10.3760/cma.j.issn.1000-6699.2017.02.018
[8]	中华医学会内分泌学分会. 中国甲状腺疾病诊治指南-甲状腺功能亢进症(2008)[J]. 中华内科杂志,2007,46(10):876-882.
[9]	Haugen B R,Alexander E K,Bible K C,et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer:The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer[J]. Thyroid,2016,26(1):1-133. doi: 10.1089/thy.2015.0020
[10]	中华医学会内分泌学分会. 《中国甲状腺疾病诊治指南》编委会. 中国甲状腺疾病诊治指南[J]. 中华内科杂志,2008,47(10):867-868.
[11]	Jang J,Kim Y,Shin J,et al. Association between thyroid hormones and the components of metabolic syndrome[J]. BMC Endocr Disord,2018,18(1):29. doi: 10.1186/s12902-018-0256-0
[12]	Michael B Zimmermann,Pieter L Jooste,Chandrakant S Pandav. Iodine-deficiency disorders[J]. Lancet,2008,372(9645):1251-1262. doi: 10.1016/S0140-6736(08)61005-3
[13]	Engle-Stone R,Vosti S A,Luo H,et al. Weighing the risks of high intakes of selected micronutrients compared with the risks of deficiencies[J]. Ann N Y Acad Sci,2019,1446(1):81-101. doi: 10.1111/nyas.14128
[14]	Kjersti Sletten Bakken,Ingvild Oma,Synne Groufh-Jacobsen,et al. The Reliability of iodine concentration in diaper-retrieved infant urine using urine collection pads,and in their mothers’ breastmilk[J]. Biomolecules,2020,10(2):295. doi: 10.3390/biom10020295
[15]	Ryoko Katagiri,Xiaoyi Yuan,Satomi Kobayashi,et al. Effect of excess iodine intake on thyroid diseases in different populations:A systematic review and meta-analyses including observational studies[J]. PLoS One,2017,12(3):e0173722. doi: 10.1371/journal.pone.0173722
[16]	Wu L,Yu J C,Kang W M,et al. Iodine nutrition and thyroid diseases[J]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao,2013,35(4):363-368.
[17]	Guo Y,Zynat J,Xu Z,et al. Iodine nutrition status and thyroid disorders:a cross-sectional study from the Xinjiang Autonomous Region of China[J]. Eur J Clin Nutr,2016,70(11):1332-1336. doi: 10.1038/ejcn.2016.82
[18]	Ma H,Li L,Li K,et al. Hashimoto’ s thyroiditis,nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients[J]. Neoplasma,2018,65(3):436-440. doi: 10.4149/neo_2018_170428N317
[19]	中华人民共和国卫生部. 食用盐碘含量（GB 26878-2011）[M]. 北京: 中国标准出版社, 2011: 252-254.
[20]	Du Y,Gao Y,Meng F,et al. Iodine deficiency and excess coexist in china and induce thyroid dysfunction and disease:a cross-sectional study[J]. PLoS One,2014,9(11):e111937. doi: 10.1371/journal.pone.0111937
[21]	Laurberg P,Bulow P I,Knudsen N,et al. Environmental iodine intake affects the type of nonmalignant thyroid disease[J]. Thyroid,2001,11(5):457-469. doi: 10.1089/105072501300176417

Relative Articles(20)

Relative Articles

[1]	Wanyou JIA, Hongli LIU, Weiwei JIANG, Hongmin LI, Shuo ZHANG, Jimin FEI. Risk Factors for Hypoparathyroidism after Thyroidectomy. Journal of Kunming Medical University, 2022, 43(9): 84-89. doi: 10.12259/j.issn.2095-610X.S20220904
[2]	Feipeng WU, Yongqiang GAO, Liju HONG, Qiyan WU, Huijun CHENG, Jiaoxia LI, Youjun ZHOU, Xiandong ZHENG. The Correlation between The Thyroid Function and Renal Function in Patients with Differentiated Thyroid Cancer under the Short-term Hypothyroidism after Withdrawal of Iodine Therapy. Journal of Kunming Medical University, 2022, 43(1): 77-83. doi: 10.12259/j.issn.2095-610X.S20220128
[3]	YAN TANG, Bo-yi LI, Rong MA, Ling NIU, Fang LIU, Cui-juan MIAO. Correlation between Urinary Iodine and Thyroid Diseases. Journal of Kunming Medical University, 2021, 42(4): 134-137. doi: 10.12259/j.issn.2095-610X.S20210425
[4]	Li Ying Hua , Gao Jing , Yuan Yuan , Wu Shi Cong , Ding Yun Chuan . . Journal of Kunming Medical University, 2020, 41(06): 95-99.
[5]	Ma Rong , Li Bo Yi , Niu Ling , Liu Fang , Yin Li Min . . Journal of Kunming Medical University, 2020, 41(09): 72-76.
[6]	Han Xiao Na , Luo Xiao Mao . . Journal of Kunming Medical University, 2020, 41(07): 71-75.
[7]	Fang ZHANG, Xue-juan GAO, Yu CHEN, Yuan FAN, Zu-kun CHEN. Advances on the Association between Hashimoto's Thyroiditis and Viral Infection. Journal of Kunming Medical University, 2020, 41(12): 148-154. doi: 10.12259/j.issn.2095-610X.S20201241
[8]	Niu Ling , Li Bo Yi , Ma Rong , Tang Yan , Liu Fang , Miao Cui Juan . . Journal of Kunming Medical University, 2020, 41(09): 98-101.
[9]	Ma Rui , Li Yan . Research Progress of Exposure to Pyrethroid Pesticides Impact on Reproductive System of Human and Physical Development of Infants. Journal of Kunming Medical University, 2019, 40(03): 126-130.
[10]	Zhang Zong Mei , Chen Ting , Yang Cheng Gang , Wu Lin , Luo Dan , Liu Ying . . Journal of Kunming Medical University, 2019, 40(09): 83-88.
[11]	Lv Yan Fen , Sun Yue , Li Yun Yan , Zhao Yi Fan , Lu Yong Ping . . Journal of Kunming Medical University, 2019, 40(06): 80-84.
[12]	Niu Ling , Li Bo Yi , Zhang Jian Wei , Zhao Xiao Li , Wang Xiao Qing , Tang Yan . . Journal of Kunming Medical University, 2017, 38(05): 78-82.
[13]	Guo Xue Jun , Miao Chun Mei , Tang Qing Wen , Jin Xue Mei , Yang Yue . Clinical Study on Thyroid Space Occupying Lesion by Ultrasound in Patients with Breast Cancer. Journal of Kunming Medical University, 2016, 37(11): 86-88.
[14]	Hai Sai Ping , Yang Li Chun . A Retrospective Analysis of Ultrasonographic Misdiagnosis of Thyroid Multiple Nodules With Thyroid Carcinoma. Journal of Kunming Medical University, 2016, 37(11): 89-92.
[15]	Qu Bo . . Journal of Kunming Medical University,
[16]	Lin Jin . . Journal of Kunming Medical University,
[17]	Chen Xue Mei . . Journal of Kunming Medical University,
[18]	Li Bing . . Journal of Kunming Medical University,
[19]	Chen Wei Wen . Clinical Study of Subclinical Hypothyroidism during Pregnancy. Journal of Kunming Medical University,
[20]	. Plain and Enhanced CT Value Changes of Roid Nodules. Journal of Kunming Medical University,