Association of Leptin and Leptin Receptor Gene Polymorphism with Coronary Slow Flow Phenomenon

Li-yong WU; Yuan CHEN; Tian-shu CHU; Qing-wen ZHENG; Guo-fu ZHU

doi:10.12259/j.issn.2095-610X.S20210328

Volume 42 Issue 3

Apr. 2021

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Li-yong WU, Yuan CHEN, Tian-shu CHU, Qing-wen ZHENG, Guo-fu ZHU. Association of Leptin and Leptin Receptor Gene Polymorphism with Coronary Slow Flow Phenomenon[J]. Journal of Kunming Medical University, 2021, 42(3): 109-114. doi: 10.12259/j.issn.2095-610X.S20210328

Citation:

Li-yong WU, Yuan CHEN, Tian-shu CHU, Qing-wen ZHENG, Guo-fu ZHU. Association of Leptin and Leptin Receptor Gene Polymorphism with Coronary Slow Flow Phenomenon[J]. Journal of Kunming Medical University, 2021, 42(3): 109-114. doi: 10.12259/j.issn.2095-610X.S20210328

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Association of Leptin and Leptin Receptor Gene Polymorphism with Coronary Slow Flow Phenomenon

doi: 10.12259/j.issn.2095-610X.S20210328

Dept. of Cardiology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-12-05
Publish Date: 2021-04-09

Abstract

Abstract

Objectives To search the risk factors of coronary slow flow phenomenon （CSFP） and to investigate the relationship between the polymorphism of leptin gene -LEP rs7799039, leptin receptor gene- LEPR rs1137100, LEPR rs1137101 and CSFP. Methods Fifty-four CSFP cases and 46 NCF cases were selected. Fasting blood glucose （FBG） and fasting insulin level （FINS） were measured. Homeostasis model resistance index （HOMA-IR） was used to evaluate insulin resistance. The serum leptin and leptin receptor concentrations were measured by enzyme-linked immunosorbent assay （ELISA）. The distribution frequency of LEP rs7799039, LEPR rs1137100 and LEPR rs1137101 were analyzed by SNaPShot technique to explore whether there is correlation between leptin and leptin receptor gene polymorphism and CSFP, and to explore the risk factors of CSFP by multivariate logistic regression analysis. Results 1. Compared with NCF group, CSFP group had higher leptin level （P = 0.000） and insulin resistance index （P = 0.046）. 2. Mean TFC of LAD （corrected）, LCX and RCA in CSFP group were higher than those in NCF group. 3.There was no significant difference in the distribution frequencies of LEP rs7799039, LEPR rs1137100 and LEPR rs1137101 between CSFP group and NCF group. 4.Logistic stepwise regression analysis showed that LEP and HOMA-IR were related risk factors for CSFP. Conclusions 1. LEP and insulin resistance are the risk factors for the development of CSFP. 2. There is no correlation between leptin and leptin receptor gene polymorphism and CSFP.
- Leptin,
- Leptin gene,
- Leptin receptor gene,
- Gene polymorphism,
- Coronary slow flow phenomenon

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References(18)

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