Application Value of IL-6, NES and Neonatal Craniocerebral UltrasoundIn Early Diagnosis of White Matter Injury in Premature Infants

Xian ZHANG; Lin ZHAO; Yan-hong LI; Jun-tao ZHANG; Meng-ru ZHAO

doi:10.12259/j.issn.2095-610X.S20210329

Volume 42 Issue 3

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 115-120

Xian ZHANG, Lin ZHAO, Yan-hong LI, Jun-tao ZHANG, Meng-ru ZHAO. Application Value of IL-6, NES and Neonatal Craniocerebral UltrasoundIn Early Diagnosis of White Matter Injury in Premature Infants[J]. Journal of Kunming Medical University, 2021, 42(3): 115-120. doi: 10.12259/j.issn.2095-610X.S20210329

Citation:

Xian ZHANG, Lin ZHAO, Yan-hong LI, Jun-tao ZHANG, Meng-ru ZHAO. Application Value of IL-6, NES and Neonatal Craniocerebral UltrasoundIn Early Diagnosis of White Matter Injury in Premature Infants[J]. Journal of Kunming Medical University, 2021, 42(3): 115-120. doi: 10.12259/j.issn.2095-610X.S20210329

Citation:

Xian ZHANG, Lin ZHAO, Yan-hong LI, Jun-tao ZHANG, Meng-ru ZHAO. Application Value of IL-6, NES and Neonatal Craniocerebral UltrasoundIn Early Diagnosis of White Matter Injury in Premature Infants[J]. Journal of Kunming Medical University, 2021, 42(3): 115-120. doi: 10.12259/j.issn.2095-610X.S20210329

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Application Value of IL-6, NES and Neonatal Craniocerebral UltrasoundIn Early Diagnosis of White Matter Injury in Premature Infants

doi: 10.12259/j.issn.2095-610X.S20210329

Dept. of Pediatrics，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-12-12
Publish Date: 2021-04-09

Abstract

Abstract

Objective To explore the value of combined IL-6, NSE and craniocerebral ultrasound in early diagnosis of white matter injury in premature infants in clinical practice. Methods The research objects of this study were 300 premature infants, 150 of whom were in the research group with white matter injury, and the early infants without white matter injury in the same period were in the control group. The duration of the study was from January 2018 to January 2020. IL-6 was tested in all preterm infants. NSE was diagnosed and the echo changes of white matter around the ventricle were observed by craniocerebral ultrasound. The specificity, sensitivity and accuracy of IL-6, NSE diagnosis were analyzed statistically. Results The detection rate of craniocerebral ultrasonography on day 1, day 3 and day 7 after birth was higher in the research group than in the control group （P < 0.05）. The gray value of craniocerebral heavy brain white matter on day 1, day 3 and day 7 after birth was compared between the two groups, the research group was all higher than the control group （P < 0.05）. Results of IL-6 and NSE on day 1, day 3 and day 7 after birth were compared between the two groups, the research group was higher than the control group （P < 0.05）. According to cranial MRI as the gold standard, the sensitivity and specificity of cranial ultrasound combined with IL-6 and NSE were 97.3% and 95.4%, both of which were superior to IL-6 and NSE, and the difference of the dominant chi-square test was statistically significant （P < 0.01）. Therefore, the three combined diagnoses could improve the diagnostic effectiveness. Conclusions IL-6, NSE and craniocerebral ultrasound are of significance for the diagnosis of white matter injury in premature infants. Combined with the above three kinds of information, the diagnosis has higher sensitivity, specificity and accuracy.
- White matter injury,
- Interleukin-6,
- Neuron-specific enolase,
- Brain ultrasound

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References(16)

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