Difference Analysis of First Liver Function Indexes of Newborns with Different Gestational Age and Birth Weight

Li-jia ZHU; Xiao-dan MA; Jiang DUAN; Meng LI; Yong-kun HUANG

doi:10.12259/j.issn.2095-610X.S20210330

Volume 42 Issue 3

Apr. 2021

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Li-jia ZHU, Xiao-dan MA, Jiang DUAN, Meng LI, Yong-kun HUANG. Difference Analysis of First Liver Function Indexes of Newborns with Different Gestational Age and Birth Weight[J]. Journal of Kunming Medical University, 2021, 42(3): 121-126. doi: 10.12259/j.issn.2095-610X.S20210330

Citation:

Li-jia ZHU, Xiao-dan MA, Jiang DUAN, Meng LI, Yong-kun HUANG. Difference Analysis of First Liver Function Indexes of Newborns with Different Gestational Age and Birth Weight[J]. Journal of Kunming Medical University, 2021, 42(3): 121-126. doi: 10.12259/j.issn.2095-610X.S20210330

Citation:

Li-jia ZHU, Xiao-dan MA, Jiang DUAN, Meng LI, Yong-kun HUANG. Difference Analysis of First Liver Function Indexes of Newborns with Different Gestational Age and Birth Weight[J]. Journal of Kunming Medical University, 2021, 42(3): 121-126. doi: 10.12259/j.issn.2095-610X.S20210330

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Difference Analysis of First Liver Function Indexes of Newborns with Different Gestational Age and Birth Weight

doi: 10.12259/j.issn.2095-610X.S20210330

1.
Dept. of Pediatrics，First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
The Sixth Affiliated Hospital of Kunming Medical University/Department of Hematology Yuxi People’s Hospital，Yuxi Yunnan 653100，China

Received Date: 2020-12-14
Publish Date: 2021-03-25

Abstract

Abstract

Objective To study the difference in the first liver function indexes of newborns with different gestational ages and birth weights. Methods We retrospectively analyzed the the first liver function indexes including total bilirubin （TBIL）, direct bilirubin （DBIL）, indirect bilirubin （IBIL）, total protein （TP） , albumin （ALB）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, alkaline phosphatase （ALP）, g-glutamyltransferase （GGT）, total bile Changes in acid （TBA）, prealbumin （PA）, cholinesterase （CHE） of 204 premature infants with different gestational ages and 206 infants with different birth weights . Then we compared and analyzed the differences of each biochemical index in each group and between groups. Results There were differences in the first liver function indexes of newborns with different gestational ages and birth weights: （1） Late preterm infant group, mid-term preterm infant group and extremely preterm infant group, the levels of TP and ALB decreased sequentially with the decreasing gestational ages （P < 0.05）; the levels of CHE had no statistically significant difference （ P > 0.05）. The levels of DBIL and GGT in late preterm infants and mid-term preterm infants were better than extremely premature infants （ P < 0.05）. （2） Compared with normal birth weight infants, only TBA increased in low birth weight infants （ P < 0.05）; Compared with very low birth weight infants, DBIL and CHE increased in normal birth weight and low birth weight infants, however, only DBIL in low birth weight infants was statistically significant （ P < 0.05）. Conclusions For newborns with different gestational ages and birth weights, the younger the gestational age, the lighter the weight, the worse the liver function. The influence of gestational age on liver function is far greater than the influence of body weight on liver function.
- First,
- Bilirubin,
- Albumin,
- Alanine aminotransferase,
- γ-glutamyltransferase,
- Total bile acid,
- Cholinesterase,
- Gestational age,
- Birth weight

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References(17)

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