Correlation between rs4580704 Polymorphism of <i>CLOCL</i> Gene and Type 2 Diabetes and Sleep Quality

Cong MEI; Xiao-chun WENG; Bao-kun PENG; Sui-jun YAN; Chun LI; Qiong ZHOU; Zhe TANG

doi:10.12259/j.issn.2095-610X.S20210332

Volume 42 Issue 3

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 135-139

Cong MEI, Xiao-chun WENG, Bao-kun PENG, Sui-jun YAN, Chun LI, Qiong ZHOU, Zhe TANG. Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality[J]. Journal of Kunming Medical University, 2021, 42(3): 135-139. doi: 10.12259/j.issn.2095-610X.S20210332

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Cong MEI, Xiao-chun WENG, Bao-kun PENG, Sui-jun YAN, Chun LI, Qiong ZHOU, Zhe TANG. Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality[J]. Journal of Kunming Medical University, 2021, 42(3): 135-139. doi: 10.12259/j.issn.2095-610X.S20210332

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Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality

doi: 10.12259/j.issn.2095-610X.S20210332

Dept of Endocrinology，The Affiliated Yan’an Hospital of Kunming Medical University， Kunming，Kunming Yunnan 650051，China

Received Date: 2020-12-01
Publish Date: 2021-03-25

Abstract

Abstract

Objective To study the effects of CLOCK rs4580704 site polymorphism on sleep quality, the effect on occurrence and development of type 2 diabetes mellitus, and the possible relevance between the two investigations. Methods We tested the polymorphism of CLOCK rs4580704 by time of flight mass spectrum, and compared indicators of genotypes and sleep quality of the case group and the control group respectively. Results The proportion of GC type and GG type of CLOCK rs4580704 in the case group was higher than that in the control group. The sleep quality of GG genotype was significantly degraded. Conclusion Allele G of CLOCK rs4580704 is possibly associated with sleep quality degradation and the occurrence and development of type 2 diabetes mellitus, while allele C is possibly the protective factor.
- Type 2 diabetes mellitus,
- CLOCK gene,
- Sleep quality,
- Single nucleotide polymorphism

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References(24)

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