Correlation between rs4580704 Polymorphism of <i>CLOCL</i> Gene and Type 2 Diabetes and Sleep Quality

Cong MEI; Xiao-chun WENG; Bao-kun PENG; Sui-jun YAN; Chun LI; Qiong ZHOU; Zhe TANG

doi:10.12259/j.issn.2095-610X.S20210332

Volume 42 Issue 3

Apr. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 135-139

Cong MEI, Xiao-chun WENG, Bao-kun PENG, Sui-jun YAN, Chun LI, Qiong ZHOU, Zhe TANG. Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality[J]. Journal of Kunming Medical University, 2021, 42(3): 135-139. doi: 10.12259/j.issn.2095-610X.S20210332

Citation:

Cong MEI, Xiao-chun WENG, Bao-kun PENG, Sui-jun YAN, Chun LI, Qiong ZHOU, Zhe TANG. Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality[J]. Journal of Kunming Medical University, 2021, 42(3): 135-139. doi: 10.12259/j.issn.2095-610X.S20210332

Citation:

PDF( 637 KB)

Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality

doi: 10.12259/j.issn.2095-610X.S20210332

Dept of Endocrinology，The Affiliated Yan’an Hospital of Kunming Medical University， Kunming，Kunming Yunnan 650051，China

Received Date: 2020-12-01
Publish Date: 2021-03-25

Abstract

Abstract

Objective To study the effects of CLOCK rs4580704 site polymorphism on sleep quality, the effect on occurrence and development of type 2 diabetes mellitus, and the possible relevance between the two investigations. Methods We tested the polymorphism of CLOCK rs4580704 by time of flight mass spectrum, and compared indicators of genotypes and sleep quality of the case group and the control group respectively. Results The proportion of GC type and GG type of CLOCK rs4580704 in the case group was higher than that in the control group. The sleep quality of GG genotype was significantly degraded. Conclusion Allele G of CLOCK rs4580704 is possibly associated with sleep quality degradation and the occurrence and development of type 2 diabetes mellitus, while allele C is possibly the protective factor.
- Type 2 diabetes mellitus,
- CLOCK gene,
- Sleep quality,
- Single nucleotide polymorphism

FullText(HTML)

References(24)

References

[1]	Li Y,Teng D,Shi X,et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association:national cross sectional study[J]. BMJ,2020,369:m997.
[2]	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中华糖尿病杂志,2018,10(1):4-67. doi: 10.3760/cma.j.issn.1674-5809.2018.01.003
[3]	Buysse D J, Reynolds C F, Monk T H, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research Psychiatry Res, 1989, 28（2）: 193-213.
[4]	路桃影,李艳,夏萍,等. 匹兹堡睡眠质量指数的信度及效度分析[J]. 重庆医学,2014,(3):260-263.
[5]	刘贤臣,唐茂芹,胡蕾,等. 匹兹堡睡眠质量指数的信度和效度研究[J]. 中华精神科杂志,1996,29(2):103-107.
[6]	Serón-Ferré M,Forcelledo M L,Torres-Farfan C,et al. Impact of chronodisruption during primate pregnancy on the maternal and newborn temperature rhythms[J]. PLoS One,2013,8(2):e57710. doi: 10.1371/journal.pone.0057710
[7]	Valenzuela F J,Torres-Farfan C,Richter H G,et al. Clock gene expression in adult primate suprachiasmatic nuclei and adrenal:is the adrenal a peripheral clock responsive to melatonin?[J]. Endocrinology,2008,149(4):1454-1461. doi: 10.1210/en.2007-1518
[8]	Feng D,Lazar M A. Clocks,metabolism,and the epigenome[J]. Mol Cell,2012,47(2):158-167. doi: 10.1016/j.molcel.2012.06.026
[9]	Reppert S M,Weaver D R. Coordination of circadian timing in mammals[J]. Nature,2002,418(6901):935-941. doi: 10.1038/nature00965
[10]	Dubocovich M L,Delagrange P,Krause D N,et al. International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature,classification,and pharmacology of G protein-coupled melatonin receptors[J]. Pharmacol Rev,2010,62(3):343-380. doi: 10.1124/pr.110.002832
[11]	Fu L,Kettner N M. The circadian clock in cancer development and therapy[J]. Prog Mol Biol Transl Sci,2013,119:221-282.
[12]	Huisman S A,Oklejewicz M,Ahmadi A R,et al. Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney[J]. Int J Cancer,2015,136(5):1024-1032. doi: 10.1002/ijc.29089
[13]	Ditisheim A J,Dibner C,Philippe J,et al. Biological rhythms and preeclampsia[J]. Front Endocrinol (Lausanne),2013,4:47.
[14]	Gao Y,Gan T,Jiang L,et al. Association between shift work and risk of type 2 diabetes mellitus:a systematic review and dose-response meta-analysis of observational studies[J]. Chronobiol Int,2020,37(1):29-46. doi: 10.1080/07420528.2019.1683570
[15]	Sharma A,Laurenti M C,Dalla Man C,et al. Glucose metabolism during rotational shift-work in healthcare workers[J]. Diabetologia,2017,60(8):1483-1490. doi: 10.1007/s00125-017-4317-0
[16]	Huang P L. A comprehensive definition for metabolic syndrome[J]. Dis Model Mech,2009,2(5-6):231-237. doi: 10.1242/dmm.001180
[17]	Kalsbeek A,la Fleur S,Fliers E. Circadian control of glucose metabolism[J]. Mol Metab,2014,3(4):372-383. doi: 10.1016/j.molmet.2014.03.002
[18]	Shamsi N A,Salkeld M D,Rattanatray L,et al. Metabolic consequences of timed feeding in mice[J]. Physiol Behav,2014,128(10):188-201.
[19]	Marcheva B,Ramsey K M,Buhr E D,et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes[J]. Nature,2010,466(7306):627-631. doi: 10.1038/nature09253
[20]	Gan Y,Yang C,Tong X,et al. Shift work and diabetes mellitus a meta-analysis of observational studies[J]. Occup Environ Med,2015,72(1):72-78.
[21]	中华医学会神经病学分会,中华医学会神经病学分会睡眠障碍学组. 中国成人失眠诊断与治疗指南(2017版)[J]. 中华神经科杂志,2018,51(5):324-335. doi: 10.3760/cma.j.issn.1006-7876.2018.05.002
[22]	Pappa K I,Gazouli M,Anastasiou E,et al. The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus[J]. Diabetes Res Clin Pract,2013,99(2):151-157. doi: 10.1016/j.diabres.2012.10.015
[23]	Kelly M A,Rees S D,Hydrie M Z,et al. Circadian gene variants and susceptibility to type 2 diabetes:a pilot study[J]. PLoS One,2012,7(4):e32670. doi: 10.1371/journal.pone.0032670
[24]	Woon P Y,Kaisaki P J,Bragança J,et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes[J]. Proc Natl Acad Sci U S A,2007,104(36):14412-14417. doi: 10.1073/pnas.0703247104

Relative Articles(20)

Relative Articles

[1]	Ling NIU, Rong MA, Cheng ZHANG, Cuijuan MIAO, Yan TANG, Fang LIU, Boyi LI. Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis. Journal of Kunming Medical University, 2024, 45(6): 106-112. doi: 10.12259/j.issn.2095-610X.S20240614
[2]	Xueya CHEN, Jinmei XU, Zhi LI, Yan LIANG, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia. Journal of Kunming Medical University, 2024, 45(11): 1-6.
[3]	Chao HONG, Xudong XIANG, Yingfu LI, Yang CAO, Xueya CHEN, Shuai LI, Anhao XING, Mu LIN, Qianli MA. Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer. Journal of Kunming Medical University, 2024, 45(3): 7-17. doi: 10.12259/j.issn.2095-610X.S20240302
[4]	Hong TAN, Hejia YIN, Yan LI, Qin HU, Lan LI, Zundan REN, Rou SHI. Correlation between DDAH1 Gene 836A/T Polymorphism and Type 2 Diabetic Kidney Disease in Yunnan Han Population. Journal of Kunming Medical University, 2023, 44(6): 26-32. doi: 10.12259/j.issn.2095-610X.S20230621
[5]	Rongshuang WU, Jiangli PENG, Yonggang CHEN, Jie CHEN, Guowei MA, Xianrui LI, Xie LI, Chunhong YU. Associations between SLC2A9 Single Nucleotide Polymorphisms and Susceptibility to Pyrazinamide Induced Hyperuricemia. Journal of Kunming Medical University, 2023, 44(4): 40-47. doi: 10.12259/j.issn.2095-610X.S20230409
[6]	Boyi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cuijuan MIAO, Cheng ZHANG, Zhujun HAN. The Relationship Between T950C Polymorphism in the Promoter Region of Osteoprotegerin Gene and Type 2 Diabetes with Osteoporosis. Journal of Kunming Medical University, 2022, 43(3): 67-73. doi: 10.12259/j.issn.2095-610X.S20220306
[7]	Bo-yi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cui-juan MIAO, Zhu-jun HAN, Cheng ZHANG. The Relationship between T950C Polymorphism in the Promoter Region of Osteoprotegerin Gene and Type 2 Diabetes with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 43(): 1-8. doi: 10.12259/j.issn.2095-610X.S20211112
[8]	Xiao-hui RUAN, Qian XIANG, Yu-ming WANG, Zhi-han ZHOU, Xian ZHANG, Yan GUO, Xiao-rui YANG. The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis. Journal of Kunming Medical University, 2021, 42(8): 132-139. doi: 10.12259/j.issn.2095-610X.S20210824
[9]	Ling NIU, Bo-yi LI, Cheng ZHANG, Rong MA, Yan TANG, Fang LIU, Li-min YIN, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. Relationship between Calcitonin Receptor，Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 42(11): 74-80. doi: 10.12259/j.issn.2095-610X.S20211114
[10]	Dong-yun LI, Shun-kui GANG, Jie LI, Ming-xing ZHANG, Lei LI. Association of ABCG2，SLC2A9，SLC17A3 and PRKG2 SNPs Variants with Gout in the Hani Population in China. Journal of Kunming Medical University, 2021, 42(3): 54-60. doi: 10.12259/j.issn.2095-610X.S20210320
[11]	Jiang ZHANG, Yan LIU, Wen-hui LI, Xi-juan ZHAO, Zheng-ting CHEN, Qiong-yao GUAN, Jiang WU. Effects of Pre-sleep Music Therapy on Sleep Quality and Cancer-related Fatigue in Patients with Breast Cancer Undergoing Radiotherapy. Journal of Kunming Medical University, 2020, 41(12): 173-178. doi: 10.12259/j.issn.2095-610X.S20201248
[12]	Xiang Xi , Li Wan Bi , Zhang Xian , Liu Hua , Wang Yu Ming , Yang Cai , Bai Yun Xia . Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients. Journal of Kunming Medical University, 2017, 38(08): 79-85.
[13]	Nian Xin . Difference of Metallothionein Gene G-201A Polymorphism in Type 2 Diabetes and Essential Hypertension. Journal of Kunming Medical University,
[14]	Xiang Xi . The Correlation between Vitamin D Receptor Gene FokI Single Nucleotide Polymorphism and Diabetic Kidney Disease. Journal of Kunming Medical University,
[15]	Long Qiong Hua . . Journal of Kunming Medical University,
[16]	Deng De Yao . . Journal of Kunming Medical University,
[17]	Yang Xiao Lei . . Journal of Kunming Medical University,
[18]	Nian Xin . The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol. Journal of Kunming Medical University, 2012, 33(02): 1-1.
[19]	Yan Xiao Hong . . Journal of Kunming Medical University,
[20]	Wang Yan . . Journal of Kunming Medical University,