Advances in Research of Astrocyte-neuron Transformation in Vivo

Jin-shan TIE; Yao LIU; Shao-chun CHEN

doi:10.12259/j.issn.2095-610X.S20210333

Volume 42 Issue 3

Apr. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 140-144

Jin-shan TIE, Yao LIU, Shao-chun CHEN. Advances in Research of Astrocyte-neuron Transformation in Vivo[J]. Journal of Kunming Medical University, 2021, 42(3): 140-144. doi: 10.12259/j.issn.2095-610X.S20210333

Citation:

Jin-shan TIE, Yao LIU, Shao-chun CHEN. Advances in Research of Astrocyte-neuron Transformation in Vivo[J]. Journal of Kunming Medical University, 2021, 42(3): 140-144. doi: 10.12259/j.issn.2095-610X.S20210333

Citation:

PDF( 550 KB)

Advances in Research of Astrocyte-neuron Transformation in Vivo

doi: 10.12259/j.issn.2095-610X.S20210333

School of Rehabilitation，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-12-16
Publish Date: 2021-04-09

Abstract

Abstract

Astrocyte-neuron transformation （ANT） is an important discovery in neuroscience field in the 21st century. Astrocytes are the largest number of glial cells and originate from the same precursor cells as neurons. Their potential to transform into neurons has brought new hope for the treatment of various neurological diseases characterized by neuronal damage or loss. There have been many successful experiments on the transformation of astrocyte-neuron in vitro, but the exploration in vivo is just beginning. Transcription factors, drugs, and microRNAs have been found to induce this transformation in animal models. Meanwhile, astrocyte-neuron transformation can be induced by pathological conditions such as Alzheimer’ s disease, spinal cord injury, focal stroke, and Parkinson’ s disease. In this paper, we systematically review the current status of studies on the transformation of astrocytes into neurons in normal and related disease animal models, and sort out the possible mechanisms of astrocytes’ reprogramming, neuronal transformation, then supplement and integration into damaged neural circuits.
- Astrocytes,
- Neuron,
- Astrocytes neuron transformation,
- Reprogramming,
- Central nervous system diseases

FullText(HTML)

References(27)

References

[1]	Li H D,Chen G. In vivo reprogramming for CNS repair:Regenerating neurons from endogenous glial cells[J]. Neuron,2016,91(4):728-738. doi: 10.1016/j.neuron.2016.08.004
[2]	Barker R A,Gotz M,Parmar M. New approaches for brain repair-from rescue to reprogramming[J]. Nature,2018,557(7705):329-334. doi: 10.1038/s41586-018-0087-1
[3]	Lei W,Li W,Ge L,et al. Non-engineered and engineered adult nurogenesis in mammalian brains[J]. Front Neurosci,2019,13(13):131.
[4]	Olof T,Ulrich P,Daniel A,et al. Generation of induced neurons via direct conversion in vivo[J]. Proceedings of the National Academy of Sciences of the United States of America,2013,110(17):7038-7043. doi: 10.1073/pnas.1303829110
[5]	Liu Y G,Miao Q L,Yuan J C,et al. Ascl1 converts dorsal midbrain astrocytes into functional neurons in vivo[J]. The Journal of Neuroscience:the Official Journal of the Society for Neuroscience,2015,35(25):9336-9355. doi: 10.1523/JNEUROSCI.3975-14.2015
[6]	Li S L,Shi Y H,Yao X,et al. Conversion of astrocytes and fibroblasts into functional noradrenergic neurons[J]. Cell Reports,2019,28(3):682-697. doi: 10.1016/j.celrep.2019.06.042
[7]	Brulet R,Matsuda T,Zhang L,et al. Neuron1 instructs neuronal conversion in non-reactive astrocytes[J]. Stem Cell Reports,2017,8(6):1506-1515. doi: 10.1016/j.stemcr.2017.04.013
[8]	Niu W,Zang T,Smith D K,et al. SOX2 reprograms resident astrocytes into neural progenitors in the adult brain[J]. Stem Cell Reports,2015,4(5):780-794. doi: 10.1016/j.stemcr.2015.03.006
[9]	Yin J C,Zhang L,Ma N X,et al. Chemical Conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways[J]. Stem Cell Reports,2019,12(3):488-501. doi: 10.1016/j.stemcr.2019.01.003
[10]	Liu M H,Li W,Zheng J J,et al. Differential neuronal reprogramming induced by NeuroD1 from astrocytes in grey matter versus white matter[J]. Neural Regen Res,2020,15(2):342-351. doi: 10.4103/1673-5374.265185
[11]	Guo Z Y,Zhang L,Wu Z,et al. In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer’ s disease model[J]. Cell Stem Cell,2014,14(2):188-202. doi: 10.1016/j.stem.2013.12.001
[12]	Su Z,Niu W,Liu M L,et al. In vivo conversion of astrocytes to neurons in the injured adult spinal cord[J]. Nat Commun,2014,5:3338. doi: 10.1038/ncomms4338
[13]	Zarei-Kheirabadi M,Hesaraki M,Kiani S,et al. In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor[J]. Stem Cell Res Ther,2019,10(1):644-653.
[14]	Yang T,Dai Y,Chen G,et al. Dissecting the dual role of the glial scar andscar-forming astrocytes in spinal cord injury[J]. Front Cell Neurosci,2020,14:78.
[15]	Yang T,Xing L,Yu W,et al. Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury[J]. FASEB J,2020,34(11):15504-15515. doi: 10.1096/fj.202001657RR
[16]	Shen S W,Duan C L,Chen X H,et al. Neurogenic effect of VEGF is related to increase of astrocytes transdifferentiation into new mature neurons in rat brains after stroke[J]. Neuropharmacology,2016,108:451-461. doi: 10.1016/j.neuropharm.2015.11.012
[17]	Yamashita T,Shang J,Nakano Y,et al. In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia[J]. Sci Rep,2019,9(1):10956. doi: 10.1038/s41598-019-47482-0
[18]	Chen Y C,Ma N X,Pei Z F,et al. A NeuroD1 AAV-Based gene therapy for functional brain repair after ischemic injury through in vivo astrocyte-to-neuron conversion[J]. Mol Ther,2020,28(1):217-234. doi: 10.1016/j.ymthe.2019.09.003
[19]	Rivetti di Val Cervo P,Romanov R A,Spigolon G,et al. Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model[J]. Nat Biotechnol,2017,35(5):444-452. doi: 10.1038/nbt.3835
[20]	Israel Z,Asch N. Reversing a Model of Parkinson's disease with in situ converted nigral neurons[J]. Mov Disord,2020,35(11):1955. doi: 10.1002/mds.28306
[21]	Wu Z,Parry M,Hou X Y,et al. Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’ s disease[J]. Nat Commun,2020,11(1):1105. doi: 10.1038/s41467-020-14855-3
[22]	Mo J L,Liu Q,Kou Z W,et al. MicroRNA-365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting Pax6[J]. Glia,2018,66(7):1346-1362. doi: 10.1002/glia.23308
[23]	Ghasemi-Kasman M,Hajikaram M,Baharvand H,et al. MicroRNA-Mediated in vitro and in vivo direct conversion ofastrocytes to neuroblasts[J]. PLoS One,2015,10(6):e0127878. doi: 10.1371/journal.pone.0127878
[24]	Magnusson J P,Göritz C,Tatarishvili J,et al. A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse[J]. Science,2014,346 (6206):237-241. doi: 10.1126/science.346.6206.237
[25]	Zamboni M,Llorens-Bobadilla E,Magnusson J P,et al. A widespread neurogenic potential of neocortical astrocytes is induced by injury[J]. Cell Stem Cell,2020,27(4):605-617. doi: 10.1016/j.stem.2020.07.006
[26]	Cieślar-Pobuda Artur,Knoflach Viktoria,Ringh Mikael V,et al. Transdifferentiation and reprogramming:Overview of the processes,their similarities and differences[J]. Biochimica et Biophysica Acta,2017,1864(7):1359-1369. doi: 10.1016/j.bbamcr.2017.04.017
[27]	徐磊,王晓冬. 星形胶质细胞诱导分化为神经细胞的研究进展[J]. 神经解剖学杂志,2018,34(3):409-412.

Relative Articles(20)

Relative Articles

[1]	Guojing LIANG, Kun JI, Kaichun ZHANG, Yufang ZHANG, Jing AN, Yuge ZHANG, Juan WEN, Haiyan REN. The Effect of Probiotics on the Expression of Aβ and the Protective Effect of Neurons in Rats with Cerebral Ischemia-Reperfusion Injury. Journal of Kunming Medical University, 2024, 45(5): 37-43. doi: 10.12259/j.issn.2095-610X.S20240506
[2]	Jinyu LI, Liangsheng FENG, Yang GAO, Yu LI, Bangxu WU, Yingying ZOU. Research Progress of DRD1 in Neurological Disorders and Functions. Journal of Kunming Medical University, 2024, 45(5): 1-7. doi: 10.12259/j.issn.2095-610X.S20240501
[3]	Kun LIAN, Yongmei LI, Chenglong SHI, Yilan CHEN, Lei ZHANG, Wei YANG, Xiufeng XU. Exploring Key Mitochondrial Autophagy Genes in Schizophrenia through Integrated Bioinformatics Approaches. Journal of Kunming Medical University, 2024, 46(): 1-13.
[4]	Ting LI, Wei-Hua GUO. Research Progress of Glycolytic Reprogramming in Oral Squamous Cell Carcinoma. Journal of Kunming Medical University, 2023, 44(6): 155-161. doi: 10.12259/j.issn.2095-610X.S20230611
[5]	Chaojie ZOU, Yikai TANG, Shuwen DU, Yuqi CHENG. Effects of Modulation of CDC42 Activity in Hippocampal Neurons on Memory and Anxiety Behaviors of Mice. Journal of Kunming Medical University, 2022, 43(11): 1-8. doi: 10.12259/j.issn.2095-610X.S20221105
[6]	Xiaobing TAN, Min ZHANG, Yu GUO, Linling DU, Qingyuan DAI. Effect of miR-130b-3p on the Reprogramming of Human Dental Origin iPSCs. Journal of Kunming Medical University, 2022, 43(12): 18-22. doi: 10.12259/j.issn.2095-610X.S20221204
[7]	Li Meng Nan , Xu Huan Huan , Liu Ya Nan , Yang Shuang , Li Chong Yang , Xu Shi Lian . . Journal of Kunming Medical University, 2020, 41(05): 7-12.
[8]	Ma Chen Li , Yang Gen Meng , Yan Qing Wen , Zhang Feng Yi , Shi Zhen Jin , Zhou Yi Qing , Wang Yi Hang , Zhao Yong Na , Zhang Dong Xian , Li Li Hua , Hong Shi Jun . Expression of Astrocyte, Neuron, and Proinflammatory Cytokines Derived from Frontal Cortex of Methamphetamine Dependent rats after Gastrodin Administration. Journal of Kunming Medical University, 2018, 39(06): 1-6.
[9]	Nie Zu Qing , Zhang Qiong , Wang Peng Fei , Yang Li Juan , Yang Wen Hong , Wang Ruo Hua , Ma Lin Kun , Yang Ming . The Changes and Sources of Cytokines in the Retina of Rats after Traumatic Optic Nerve Injury. Journal of Kunming Medical University, 2017, 38(04): 22-27.
[10]	An Yuan . Effect of Blood Purification on Septic Encephalopathy Neuron-specific Enolase. Journal of Kunming Medical University,
[11]	Deng Yong Qian . . Journal of Kunming Medical University, 2015, 36(09): 1-1.
[12]	Yu Yang . . Journal of Kunming Medical University,
[13]	Li Jun Yan . . Journal of Kunming Medical University,
[14]	Li Qi . . Journal of Kunming Medical University,
[15]	Liu Ao Xiang . . Journal of Kunming Medical University,
[16]	Li Jing Tao . P38-一种信号分子在神经系统疾病中的作用. Journal of Kunming Medical University,
[17]	Shao Jian Lin . . Journal of Kunming Medical University, 2012, 33(04): 1-2.
[18]	Duan Yan Ping . The Changes of Nogo-A Expression in the Neurons of Acute Complete SCI Rats after GAP-43 Therapy. Journal of Kunming Medical University, 2011, 32(12): 1-1.
[19]	Mao Xi Hong . Pathological Study of PNS in Regulating Cathepsin B Expression in Rabbits with Pulmonary Fibrosis of Pulmonary Heart Disease. Journal of Kunming Medical University,
[20]	. Specific Identification of Neurons and Astrocytes in Spinal Cords of Adult Monkeys and Rats. Journal of Kunming Medical University,