Volume 42 Issue 4
Apr.  2021
Turn off MathJax
Article Contents
Abstract
References
Relative Articles
Article Navigation >  Journal of Kunming Medical University  > 2021  >  42(4): 8-12
Discussion on 99mTc-MDP Bone Scan Review Time for Patients with Lung Cancer[J]. Journal of Kunming Medical University, 2011, 32(03).
Citation: Na PI, Qin HE, Yan ZHONG, Xuan JIN, Zhen-dong ZHU, Xuan ZHANG. Effect of Gentiana Rigescens Franch on Expression of NF - κ B and CTGF in Lung Tissue of Mice with Pulmonary Fibrosis[J]. Journal of Kunming Medical University, 2021, 42(4): 8-12. doi: 10.12259/j.issn.2095-610X.S20210402
shu

Effect of Gentiana Rigescens Franch on Expression of NF - κ B and CTGF in Lung Tissue of Mice with Pulmonary Fibrosis

doi: 10.12259/j.issn.2095-610X.S20210402
  • 1.

    School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500

  • 2.

    Dept. of Geriatrics，The 3rd People’s Hospital of Yunnan Province，The 2nd Affiliated Hospital of Dali University，Kunming Yunnan 650011，China

  • Received Date: 2020-12-07
  • Publish Date: 2021-04-01
    Abstract
  •   Objective  To study the effect of Gentiana rigescens Franch on the protein expression of NF - κ B and CTGF in lung tissue of mice with pulmonary fibrosis.  Methods  The model of pulmonary fibrosis in Kunming mice was established by intratracheal instillation of bleomycin （5 mg·kg-1）. Low, medium and high doses （50, 100, 200 mg·kg-1） of Gentiana rigescens Franch were administered intragastrically once a day. Pirfenidone was used as positive control. The mice were killed on the 28th day after modeling, and the lung tissues were taken for detection. Gross pathological changes of lung tissue were observed by naked eyes. Masson staining was used to observe the degree of pulmonary fibrosis. Western blot was used to detect the expression of NF - κ B and CTGF in lung tissue.  Results  Compared with the model group, the collagen deposition in lung tissue of mice was significantly reduced in different doses of Gentiana rigescens group and positive drug Pirfenidone group. Compared with the model group, the protein expression of NF - κ B and CTGF in lung tissue of mice were significantly down-regulated in different doses of Gentiana rigescens group and positive drug bifidone group （P < 0.05）.  Conclusion  Gentiana rigescens Franch has anti-pulmonary fibrotic effect, the anti-fibrotic mechanism is related to inhibiting lung inflammation and collagen deposition througth down-regulating the protein expression of NF - κ B and CTGF.
    • FullText(HTML)
    • References(19)
  • [1]
    Lederer D J,Martinez F J. Idiopathic Pulmonary Fibrosis[J]. N Engl J Med,2018,378(19):1811-1823. doi: 10.1056/NEJMra1705751
    [2]
    Sköld C M,Bendstrup E,Myllärniemi M,et al. Treatment of idiopathic pulmonary fibrosis:A position paper from a nordic expert group[J]. J Intern Med,2017,281(2):149-166. doi: 10.1111/joim.12571
    [3]
    Sathiyamoorthy G,Sehgal S,Ashton R W. Pirfenidone and nintedanib for treatment of idiopathic pulmonary fibrosis[J]. South Med J,2017,110(6):393-398. doi: 10.14423/SMJ.0000000000000655
    [4]
    张金渝,沈涛,杨维泽,等. 云南道地药材滇龙胆资源调查与评价[J]. 植物遗传资源学报,2012,13(05):890-895. doi: 10.3969/j.issn.1672-1810.2012.05.030
    [5]
    潘旭,朱鹤云,张昌浩,等. 龙胆化学成分和药理作用研究进展[J]. 吉林医药学院学报,2020,41(02):150-151.
    [6]
    屈朝霞,马朝东,王文林. 苦胆草对斯氏狸殖吸虫致大鼠肝纤维化中TIMP-1表达的影响[J]. 江苏大学学报(医学版),2010,20(05):389-391.
    [7]
    王应霞,张丽,张旋,等. 苦胆草对博莱霉素致大鼠肺纤维化的防治作用[J]. 昆明医科大学学报,2016,37(05):38-41. doi: 10.3969/j.issn.1003-4706.2016.05.009
    [8]
    Knudsen L,Ruppert C,Ochs M. Tissue remodelling in pulmonary fibrosis[J]. Cell Tissue Res.,2017,367(3):607-626. doi: 10.1007/s00441-016-2543-2
    [9]
    Meyer K C. Pulmonary fibrosis,part I:epidemiology,pathogenesis,and diagnosis[J]. Expert Rev Respir Med,2017,11(5):343-359.
    [10]
    Lalle G,Twardowski J,Grinberg-Bleyer Y. NF-κB in Cancer Immunity:Friend or Foe[J]. Cells,2021,10(2):355. doi: 10.3390/cells10020355
    [11]
    Zhang Q,Lenardo M J,Baltimore D. 30 Years of NF-κB:A Blossoming of Relevance to Human Pathobiology[J]. Cell,2017,168(1-2):37-57. doi: 10.1016/j.cell.2016.12.012
    [12]
    Chang X,Zhu A,Liu F,et al. Role of NF-κB activation and Th1/Th2 imbalance in pulmonary toxicity induced by nano NiO[J]. Environ Toxicol,2017,32(4):1354-1362. doi: 10.1002/tox.22329
    [13]
    Peng L,Wen L,Shi Q F,et al. Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation[J]. Cell Death Dis,2020,11(11):978. doi: 10.1038/s41419-020-03178-2
    [14]
    石勤业,郭剑,徐建红. 核转录因子κB及其抑制因子研究[J]. 医学信息,2020,33(22):45-47. doi: 10.3969/j.issn.1006-1959.2020.22.014
    [15]
    王妍妮,王昌明. 肿瘤坏死因子α诱导核转录因子κB信号通路在特发性肺纤维化中的作用机制[J]. 国际呼吸杂志,2014,34(24):1886-1889. doi: 10.3760/cma.j.issn.1673-436X.2014.24.013
    [16]
    Ma T,Dong L J,Du X L,et al. Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy[J]. Int J Ophthalmol,2018,11(9):1550-1554.
    [17]
    Ramazani Y,Knops N,Elmonem M A,et al. Connective tissue growth factor(CTGF)from basics to clinics[J]. Matrix Biol,2018,69(3):44-66.
    [18]
    邹梦林,胡星星,张铭杨,等. ERK1/2信号通过钙蛋白酶调控结缔组织生长因子参与肺纤维化的形成[J]. 武汉大学学报(医学版),2020,41(5):720-724.
    [19]
    梁瑞娟. 雾化吸入布地奈德对肺纤维化大鼠肺组织TGF-β和CTGF表达的影响研究[J]. 北方药学,2018,15(3):158-159. doi: 10.3969/j.issn.1672-8351.2018.03.135
    • Relative Articles(20)

  • Relative Articles

    [1] Yanbo YUAN, Zhaojuan RUAN, Liangju CAO, Wanjuan YANG, Yu JIANG, Xue ZHOU. Content Analysis of Concentrated Growth Factor Fibrin Gel in Patients with Type 2 Diabetes Mellitus. Journal of Kunming Medical University, 2023, 44(7): 125-129.  doi: 10.12259/j.issn.2095-610X.S20230720
    [2] Yegang HU, Wei ZHANG. Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat. Journal of Kunming Medical University, 2022, 43(4): 6-11.  doi: 10.12259/j.issn.2095-610X.S20220402
    [3] Yong-jun LIU, Yin WANG, Mei YANG, E-gao YIN, Ting LI, Zhao-xing DONG. The Effect of Hydrogen-Regulated Autophagy on Pulmonary Fibrosis in Paraquat Poisoned Rats. Journal of Kunming Medical University, 2021, 42(9): 1-6.  doi: 10.12259/j.issn.2095-610X.S20210918
    [4] Jin Jin Hua , Li Ke Yan , Zhang Ling , Wang Yu Hui , Deng Xiao Ming . . Journal of Kunming Medical University, 2020, 41(02): 16-20.
    [5] Wang Li Yu , He Hong Bing , Tan Jin Zhang , Ren Xiao Bin . Effect of Yunnan Baiyao on Cytokines Releasing from Platelet Rich-Fibrin in Human. Journal of Kunming Medical University, 2019, 40(03): 35-38.
    [6] Li Ting , Deng Shu Hao , Liu Yong Jun , Dong Zhao Xing . . Journal of Kunming Medical University, 2019, 40(08): 1-5.
    [7] Tai Wen Lin , Ding Jia Wei , Zheng Bo Yang , Wu Han Xin , Gao Ling , Zhang Wei , Dong Zhao Xing , Xu Yi Heng . . Journal of Kunming Medical University, 2017, 38(03): 21-26.
    [8] Li Ye . Expression and Effects of New Fibrotic Gene SFTPA2 in Unilateral Ureteral Obstruction Rats with Renal Interstitial Fibrosis. Journal of Kunming Medical University,
    [9] Lei Wen . IL-27 Alleviates the Bleomycin-induced Pulmonary Fibrosis through Regulating TGF-β/Smad Signaling Pathway. Journal of Kunming Medical University,
    [10] Wang Ying Xia . Anti-fibrotic Effect of Kudancao Tablets on Bleomycin-induced Pulmonary Fibrosis in Rats. Journal of Kunming Medical University,
    [11] Wang Ye . . Journal of Kunming Medical University,
    [12] He Xiao Yu . . Journal of Kunming Medical University,
    [13] Tang Ying . . Journal of Kunming Medical University, 2015, 36(08): 1-1.
    [14] He Xiao Yu . . Journal of Kunming Medical University,
    [15] Dong Zhao Xing . . Journal of Kunming Medical University,
    [16] Zhang Xi Jun . . Journal of Kunming Medical University,
    [17] Li Fan. . Journal of Kunming Medical University,
    [18] Liu Dong . . Journal of Kunming Medical University,
    [19] Zhu Li Rong . . Journal of Kunming Medical University,
    [20] Zhang Ji Zhou . Effect of Exogenous Carbon Monoxide on Gaseous Signaling Molecules in Hippocampus of Rats with Cerebral Ischemic-Reperfusion Injury. Journal of Kunming Medical University,
    • Supplements(0)
    • Cited By

  • Cited by

    Periodical cited type(10)

    1. 庄晓杰，蔡尧天，张曦，高俊. 补气类中药对骨修复的调控作用及机制探讨. 中医药临床杂志. 2024(10): 1867-1872 .
    2. 逯子衡，林晓云，张勇龙，王艳君. 电针治疗膝骨关节炎作用机制研究进展. 辽宁中医药大学学报. 2023(03): 97-101 .
    3. 王雷，余德涛，邢祯全. 依托考昔抑制SDF-1/CXCR4信号通路影响骨关节炎软骨细胞增殖、凋亡及炎性因子表达. 现代免疫学. 2021(06): 468-472 .
    4. 宋国瑞，张晨，刘子歌，程萌旗，陈德胜. JAK2-STAT3信号通路介导骨关节炎发病机制的研究进展. 医学综述. 2020(07): 1278-1282 .
    5. 张来鑫，谢大伟，李青松，邢家辉，钱伟萍. miR-1275/SIRT2信号轴在骨关节炎软骨细胞增殖凋亡中的作用. 广西医科大学学报. 2020(10): 1830-1836 .
    6. 谢文鹏，徐龙进，王象鹏，宋绪钰，毕荣修. p38 MAPK信号通路在膝关节骨性关节炎中医药诊疗中的作用. 中国实验方剂学杂志. 2019(08): 219-225 .
    7. 尤君怡，龚正丰，梁国强. 吴门芪藤汤对佐剂性关节炎大鼠膝骨关节滑膜、软骨组织细胞凋亡的影响. 河北中医. 2019(02): 262-267+274 .
    8. 蔡军，于刚，秦晗. 右美托咪定对小鼠成骨细胞RANKL/RANK/OPG信号通路的影响. 广东医学. 2019(06): 758-761 .
    9. 罗淦，汤样华，康仪，辛大伟，熊振飞，徐灿达，岳振双，曾林如. 骨关节炎相关信号通路的研究进展. 中医正骨. 2019(05): 31-37 .
    10. 谭旭仪，邝高艳，卢敏. 膝骨关节炎的“虚、瘀、毒”病机特点探析. 中国实验方剂学杂志. 2018(24): 201-206 .

    Other cited types(9)

  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-040100200300400
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 3.2 %其他: 3.2 %其他: 0.2 %其他: 0.2 %Arrowtown: 0.0 %Arrowtown: 0.0 %China: 0.0 %China: 0.0 %Falkenstein: 0.3 %Falkenstein: 0.3 %San Mateo: 0.1 %San Mateo: 0.1 %上海: 3.1 %上海: 3.1 %东莞: 0.1 %东莞: 0.1 %临沂: 0.0 %临沂: 0.0 %乐山: 0.0 %乐山: 0.0 %九江: 0.0 %九江: 0.0 %保定: 0.2 %保定: 0.2 %六盘水: 0.1 %六盘水: 0.1 %北京: 39.6 %北京: 39.6 %十堰: 0.2 %十堰: 0.2 %南京: 0.3 %南京: 0.3 %南通: 0.3 %南通: 0.3 %博阿努瓦: 0.1 %博阿努瓦: 0.1 %厦门: 0.0 %厦门: 0.0 %吉林: 0.1 %吉林: 0.1 %呼和浩特: 0.0 %呼和浩特: 0.0 %咸阳: 0.0 %咸阳: 0.0 %哈尔滨: 0.1 %哈尔滨: 0.1 %哥伦布: 0.0 %哥伦布: 0.0 %嘉兴: 0.1 %嘉兴: 0.1 %坦佩: 0.0 %坦佩: 0.0 %天津: 0.8 %天津: 0.8 %宁波: 0.1 %宁波: 0.1 %安康: 0.0 %安康: 0.0 %安阳: 0.2 %安阳: 0.2 %宣城: 0.2 %宣城: 0.2 %密蘇里城: 0.0 %密蘇里城: 0.0 %常州: 0.2 %常州: 0.2 %广州: 0.1 %广州: 0.1 %庆阳: 0.0 %庆阳: 0.0 %延安: 0.0 %延安: 0.0 %张家口: 0.9 %张家口: 0.9 %德宏: 0.1 %德宏: 0.1 %成都: 0.3 %成都: 0.3 %扬州: 0.7 %扬州: 0.7 %承德: 0.0 %承德: 0.0 %新德里: 0.1 %新德里: 0.1 %无锡: 0.1 %无锡: 0.1 %昆明: 4.0 %昆明: 4.0 %普洱: 0.0 %普洱: 0.0 %景德镇: 0.0 %景德镇: 0.0 %杭州: 1.2 %杭州: 1.2 %武汉: 0.1 %武汉: 0.1 %江门: 0.1 %江门: 0.1 %沈阳: 0.2 %沈阳: 0.2 %泽西: 0.1 %泽西: 0.1 %洛阳: 0.2 %洛阳: 0.2 %淄博: 0.1 %淄博: 0.1 %深圳: 0.1 %深圳: 0.1 %温州: 0.2 %温州: 0.2 %漯河: 1.6 %漯河: 1.6 %玉溪: 0.1 %玉溪: 0.1 %石家庄: 0.2 %石家庄: 0.2 %福州: 0.0 %福州: 0.0 %红河: 0.1 %红河: 0.1 %芒廷维尤: 12.1 %芒廷维尤: 12.1 %芝加哥: 0.9 %芝加哥: 0.9 %苏州: 0.0 %苏州: 0.0 %荆州: 0.0 %荆州: 0.0 %蚌埠: 0.0 %蚌埠: 0.0 %襄阳: 0.0 %襄阳: 0.0 %西宁: 6.3 %西宁: 6.3 %西安: 0.1 %西安: 0.1 %西雅图: 0.2 %西雅图: 0.2 %诺沃克: 0.0 %诺沃克: 0.0 %贵阳: 0.1 %贵阳: 0.1 %贾姆谢德布尔: 0.0 %贾姆谢德布尔: 0.0 %运城: 0.2 %运城: 0.2 %遵义: 0.0 %遵义: 0.0 %邯郸: 0.2 %邯郸: 0.2 %郑州: 0.4 %郑州: 0.4 %重庆: 0.1 %重庆: 0.1 %金奈: 0.0 %金奈: 0.0 %铁岭: 0.0 %铁岭: 0.0 %银川: 0.0 %银川: 0.0 %长沙: 1.0 %长沙: 1.0 %雅加达: 0.2 %雅加达: 0.2 %青岛: 0.5 %青岛: 0.5 %马鞍山: 0.0 %马鞍山: 0.0 %驻马店: 15.3 %驻马店: 15.3 %黄冈: 0.3 %黄冈: 0.3 %其他其他ArrowtownChinaFalkensteinSan Mateo上海东莞临沂乐山九江保定六盘水北京十堰南京南通博阿努瓦厦门吉林呼和浩特咸阳哈尔滨哥伦布嘉兴坦佩天津宁波安康安阳宣城密蘇里城常州广州庆阳延安张家口德宏成都扬州承德新德里无锡昆明普洱景德镇杭州武汉江门沈阳泽西洛阳淄博深圳温州漯河玉溪石家庄福州红河芒廷维尤芝加哥苏州荆州蚌埠襄阳西宁西安西雅图诺沃克贵阳贾姆谢德布尔运城遵义邯郸郑州重庆金奈铁岭银川长沙雅加达青岛马鞍山驻马店黄冈

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (4137) PDF downloads(26) Cited by(19)
    Proportional views
    Related

    Copyright © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    Publishing: 昆明医科大学学报编辑部

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return