A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats

Xia-rong GONG; Li-gong BIAN; Yu-hui CHEN; Jing CHEN; Bo WANG; Guo-li BI

doi:10.12259/j.issn.2095-610X.S20210405

Volume 42 Issue 4

Apr. 2021

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Xia-rong GONG, Li-gong BIAN, Yu-hui CHEN, Jing CHEN, Bo WANG, Guo-li BI. A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats[J]. Journal of Kunming Medical University, 2021, 42(4): 28-32. doi: 10.12259/j.issn.2095-610X.S20210405

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Xia-rong GONG, Li-gong BIAN, Yu-hui CHEN, Jing CHEN, Bo WANG, Guo-li BI. A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats[J]. Journal of Kunming Medical University, 2021, 42(4): 28-32. doi: 10.12259/j.issn.2095-610X.S20210405

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A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats

doi: 10.12259/j.issn.2095-610X.S20210405

1.
MRI Department，The 1st People’s Hospital of Yunnan Province，Kunming Yunnan 650032
2.
Dept. of Anatomy，Histology and Embryology，School of Basic Medicine, Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-11-09
Publish Date: 2021-04-25

Abstract

Abstract

Objective To investigate brain abnormalities in rats with acute epilepsy by diffusional kurtosis imaging （DKI）. Methods MRI were performed on all rats. DKI images were obtained from 13 epilepsy rats and 9 normal controls. Fractional anisotropy （FA）, mean diffusivity （MD）, and mean kurtosis （MK）, axial kurtosis（K∥）, radial kurtosis（K⊥） of bilateral hippocampus, piriform cortex and entorhinal cortex were measured. SPSS 17.0 was used for statistical analysis. Results Compared with the control group, MD of bilateral piriform cortex/entorhinal cortex decreased, MK、K∥、K⊥ significantly increased in the model group （P < 0.05）. There were no statistically significant differences in FA, MD, MK, K∥ and K⊥ in the bilateral hippocampus of model group. Conclusion Using DKI to reveal the pathologic changes of rats with acute epilepsy provide theoretical basis for the pathophysiological changes of brain tissues of rats with acute epilepsy.
- Epilepsy,
- Rat,
- Diffusion kurtosis imaging

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References(19)

References

[1]	Singh A,Trevick S. The epidemiology of global epilepsy[J]. Neurol Clin,2016,34(4):837-847. doi: 10.1016/j.ncl.2016.06.015
[2]	Jensen J H,Helpern J A. MRI quantification of non-Gaussian water diffusion by kurtosis analysis[J]. NMR Biomed,2010,23(7):698-710. doi: 10.1002/nbm.1518
[3]	Fieremans E,Jensen J H,Helpern J A. White matter characterization with diffusional kurtosis imaging[J]. Neuroimage,2011,58(1):177-188. doi: 10.1016/j.neuroimage.2011.06.006
[4]	Glenn G R,Jensen J H,Helpern J A,et al. Epilepsy-related cytoarchitectonic abnormalities along white matter pathways[J]. Journal of Neurology,Neurosurgery,and Psychiatry,2016,87(9):930-936. doi: 10.1136/jnnp-2015-312980
[5]	Surova Y,Nilsson M,Lampinen B,et al. Alteration of putaminal fractional anisotropy in parkinson's disease:A longitudinal diffusion kurtosis imaging study[J]. Neuroradiology,2018,60(3):247-254. doi: 10.1007/s00234-017-1971-3
[6]	Karlsen R H,Einarsen C,Moe H K,et al. Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome[J]. Journal of Neuroscience Research,2019,97(5):568-581. doi: 10.1002/jnr.24383
[7]	龚霞蓉,吴昆华,赵英,等. 锂-匹罗卡品诱导癫痫大鼠急性期MRI表现[J]. 中华神经医学杂志,2019,18(10):1035-1037.
[8]	Jones D K,Knösche T R,Turner R. White matter integrity,fiber count,and other fallacies:The do's and don'ts of diffusion MRI[J]. Neuroimage,2013,73(6):239-254.
[9]	Jensen J H,Helpern J A,Tabesh A. Leading non-gaussian corrections for diffusion orientation distribution function[J]. NMR Biomed,2014,27(2):202-211. doi: 10.1002/nbm.3053
[10]	Jensen J H,Helpern J A,Ramani A,et al. Diffusional kurtosis imaging:The quantification of non-gaussian water diffusion by means of magnetic resonance imaging[J]. Magn Reson Med,2005,53(6):1432-1440. doi: 10.1002/mrm.20508
[11]	Lazar M,Jensen J H,Xuan L,et al. Estimation of the orientation distribution function from diffusional kurtosis imaging[J]. Magn ResonMed,2008,60(4):774-781. doi: 10.1002/mrm.21725
[12]	Hori M,Fukunaga I,Masutani Y,et al. New diffusion metrics for spondylotic myelopathy at an early clinical stage[J]. Eur Radiol,2012,22(8):1797-1802. doi: 10.1007/s00330-012-2410-9
[13]	Veraart J,Poot D H,Van Hecke W,et al. More accurate estimation of diffusion tensor parameters using diffusion kurtosis imaging[J]. Magn Reson Med,2011,65(1):138-145.
[14]	Choy M, Cheung K K, Thomas D L, et al. Quantitative MRI predicts status epilepticus-induced hippocampal injury in the lithium-pilocarpine rat model[J], Epilepsy Research, 2010, 88（2-3）: 221-230.
[15]	曾丁巳,肖新兰. 扩散峰度成像在中枢神经系统的应用[J]. 临床放射学杂志,2011,30(9):1400-1402.
[16]	陈建新,付丽媛,梁永刚,等. 颞叶癫痫患者发作间期内侧颞叶磁共振动态磁敏感对比增强灌注成像研究[J]. 中国CT和MRI杂志,2017,15(1):7-10.
[17]	丁秀芳. 癫痫持续状态模型中海马神经元损伤及其可能机制的研究[D]. 济南: 山东大学硕士论文, 2016.
[18]	Valle-Dorado M G,Santana-Gómez C E,Orozco-Suárez S A,et al. The mast cell Stabilizer sodium cromoglycate reduces histamine release and status Epilepticus-induced neuronal damage in the rat hippocampus[J]. Neuropharmacology,2015,92(5):49-55.
[19]	Engelhorn T,Doerfler A,Weise J,et al. Cerebral perfusion alterations during the acute phase of experimental generalized status epilepticus:Prediction of survival by using perfusion-weighted MR imaging and histopathology[J]. AJNR,2005,26(6):1563-1570.

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