A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats

Xia-rong GONG; Li-gong BIAN; Yu-hui CHEN; Jing CHEN; Bo WANG; Guo-li BI

doi:10.12259/j.issn.2095-610X.S20210405

Volume 42 Issue 4

Apr. 2021

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Xia-rong GONG, Li-gong BIAN, Yu-hui CHEN, Jing CHEN, Bo WANG, Guo-li BI. A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats[J]. Journal of Kunming Medical University, 2021, 42(4): 28-32. doi: 10.12259/j.issn.2095-610X.S20210405

Discussion on 99mTc-MDP Bone Scan Review Time for Patients with Lung Cancer[J]. Journal of Kunming Medical University, 2011, 32(03).

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A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats

doi: 10.12259/j.issn.2095-610X.S20210405

1.
MRI Department，The 1st People’s Hospital of Yunnan Province，Kunming Yunnan 650032
2.
Dept. of Anatomy，Histology and Embryology，School of Basic Medicine, Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-11-09
Publish Date: 2021-04-25

Abstract

Abstract

Objective To investigate brain abnormalities in rats with acute epilepsy by diffusional kurtosis imaging （DKI）. Methods MRI were performed on all rats. DKI images were obtained from 13 epilepsy rats and 9 normal controls. Fractional anisotropy （FA）, mean diffusivity （MD）, and mean kurtosis （MK）, axial kurtosis（K∥）, radial kurtosis（K⊥） of bilateral hippocampus, piriform cortex and entorhinal cortex were measured. SPSS 17.0 was used for statistical analysis. Results Compared with the control group, MD of bilateral piriform cortex/entorhinal cortex decreased, MK、K∥、K⊥ significantly increased in the model group （P < 0.05）. There were no statistically significant differences in FA, MD, MK, K∥ and K⊥ in the bilateral hippocampus of model group. Conclusion Using DKI to reveal the pathologic changes of rats with acute epilepsy provide theoretical basis for the pathophysiological changes of brain tissues of rats with acute epilepsy.
- Epilepsy,
- Rat,
- Diffusion kurtosis imaging

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References(19)

References

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