Analysis of Serum Fat-soluble Vitamin Levels in Infants and Children in Anning City

Yan GAO; Xiang-lei TONG; Hao-ran TANG; Li WU

doi:10.12259/j.issn.2095-610X.S20210408

Volume 42 Issue 4

Apr. 2021

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Yan GAO, Xiang-lei TONG, Hao-ran TANG, Li WU. Analysis of Serum Fat-soluble Vitamin Levels in Infants and Children in Anning City[J]. Journal of Kunming Medical University, 2021, 42(4): 44-48. doi: 10.12259/j.issn.2095-610X.S20210408

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Yan GAO, Xiang-lei TONG, Hao-ran TANG, Li WU. Analysis of Serum Fat-soluble Vitamin Levels in Infants and Children in Anning City[J]. Journal of Kunming Medical University, 2021, 42(4): 44-48. doi: 10.12259/j.issn.2095-610X.S20210408

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Analysis of Serum Fat-soluble Vitamin Levels in Infants and Children in Anning City

doi: 10.12259/j.issn.2095-610X.S20210408

Dept. of Pediatrics，Yunnan Kungang Hospital，Anning Yunnan 650302，China

Received Date: 2021-02-03
Publish Date: 2021-04-01

Abstract

Abstract

Objective To investigate the serum fat-soluble vitamins levels in infants and children in Anning City, to provide reference data for reasonable fat-soluble vitamin supplementation. Methods From June 2019 to July 2020, 925 infants and children from Children’ s Physical Examination Center of Kungang Hospital were selected. High performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） was used to test the serum fat-soluble vitamins quantitatively. Then the fat-soluble vitamins levels were analyzed based on different ages, genders, and seasons. Results The average levels as well as insufficiency and deficient rates of serum vitamin A, 25-hydroxyvitamin D3, vitamin E and vitamin K in 925 infants and children were （284±3.84） ng/mL, 61.08%（565/925）; （34.27±0.46）ng/mL, 1.73%（16/925）; （8.47±0.16）μg/mL, 12.11%（112/925） and （0.46±0.03）ng/mL, 19.68%（182/925）, respectively. There were differences between different age groups （age range 0-3, 4-6, 7-12） and seasons （P < 0.01）. Conclusion There was a serious deficiency of vitamin A, which requires close attention and reasonable supplement. Due to the natural sunshine advantage in Yunnan, vitamin D nutrition level is relatively good, and excessive supplementation should be avoided.
- Children,
- Vitamin A,
- Vitamin D,
- Vitamin E,
- Vitamin K

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References(24)

References

[1]	白英杰, 黄姗姗, 汪云. 维生素A和维生素D及维生素E与儿童反复呼吸道感染的相关性研究[J]. 中国医药,2020,15(10):1542-1544.
[2]	杨春, 陈竞, 云春凤, 等. 中国中小城市小学生维生素A缺乏和贫血现况调查[J]. 卫生研究,2016,45(3):489-491.
[3]	Alshamrani Hassan A, Alloub Hana, Burke Derek, et al. Vitamin D intake, calcium intake and physical activity among children with wrist and ankle injuries and the association with fracture risk[J]. Nutr Health,2019,25(2):113-118. doi: 10.1177/0260106019826422
[4]	Kuchan Matthew J, Jensen Søren K, Johnson Elizabeth J, et al. The naturally occurring α-tocopherol stereoisomer RRR-α-tocopherol is predominant in the human infant brain[J]. Br J Nutr,2016,116(1):126-31. doi: 10.1017/S0007114516001719
[5]	刘永英, 李昉明, 陈一菁, 程明, 李宏. 133例非创伤性婴儿颅内出血的临床特征分析[J]. 新医学,2020,51(2):113-116. doi: 10.3969/j.issn.0253-9802.2020.02.007
[6]	Holick Michael F, Binkley Neil C, Bischoff-Ferrari Heike A, et al. Evaluation, treatment, and prevention of vitamin deficiency: an Endocrine Society clinical practice guideline[J]. J Clin Endocrinol Metab,2011,96(7):1911-1930. doi: 10.1210/jc.2011-0385
[7]	Zhang Yuning, Bala Veenu, Mao Zhihao, et al. Quantification of fat-soluble vitamins and their metabolites in biological matrices: an updated review[J]. Bioanalysis,2020,12(9):625-640. doi: 10.4155/bio-2020-0069
[8]	Le Juan, Yuan Tengfei, Zhang Yan, et al. New LC-MS/MS method with single-step pretreatment analyzes fat-soluble vitamins in plasma and amniotic fluid[J]. Journal of Lipid Research,2018,59(9):1783-1790. doi: 10.1194/jlr.D087569
[9]	Albahrani A A, Rotarou V, Roche P J, et al. A simultaneous quantitative method for vitamins A, D and E in human serum using liquid chromatography-tandem mass spectrometry[J]. J Steroid Biochem Mol Biol,2016,159(5):41-53.
[10]	Katsa M, Papalouka N, Mavrogianni T, et al. Comparative study for the determination of fat-soluble vitamins in rice cereal baby foods using HPLC-DAD and UHPLC-APCI-MS/MS[J]. Foods,2021,10(3):648. doi: 10.3390/foods10030648
[11]	金春华.中国儿童维生素A、E缺乏与呼吸道感染[M].北京:人民卫生出版社, 2019: 176-690.
[12]	李少维, 林惠玲, 叶桂青, 等. 婴幼儿及儿童血清维生素A、维生素E及维生素D水平分析[J]. 中国妇幼健康研究,2020,31(9):1161-1165. doi: 10.3969/j.issn.1673-5293.2020.09.008
[13]	Chen Yu-Juan, Liu Miao, Mao Cui-Yin, et al. An Investigation of Vitamin Levels Status in the Serum of children in China[J]. Biomed Res Int,2018,18(11):6592757.
[14]	Miyazawa Taiki, Burdeos Gregor C, Itaya Mayuko, et al. Vitamin E: Regulatory redox interactions[J]. IUBMB Life,2019,71(4):430-441. doi: 10.1002/iub.2008
[15]	陈曦, 宫照龙, 沈葹. 超高效液相色谱-三重四级杆串联质谱法测定血清中维生素A和维生素E[J]. 卫生研究,2021,50(2):301-307.
[16]	荣爽, 徐凯, 李婷婷, 等. 维生素与免疫功能[J]. 营养学报,2020,42(6):613-617. doi: 10.3969/j.issn.0512-7955.2020.06.020
[17]	谢荣, 李少维, 郑春梅, 等. 健康儿童血清维生素E水平现状分析[J]. 中国儿童保健杂志,2020,28(6):696-698.
[18]	吴碧琛, 丁妞, 饶花平, 等. 不同年龄罹患不同呼吸道疾病儿童维生素A、E的水平分析[J]. 中国医师杂志,2020,22(10):1497-1500. doi: 10.3760/cma.j.cn431274-20200623-00857
[19]	傅卓, 付俊鲜, 杨光路. 儿童肺炎支原体肺炎外周血血清维生素A、D、E的变化及相关性[J]. 内蒙古医科大学学报,2020,42(5):495-496.
[20]	陈洁琳, 覃敏, 杨晓祥, 等. 反复呼吸道感染儿童的免疫状态与维生素A/E缺乏情况[J]. 广西医学,2020,42(17):2199-2201.
[21]	金春华, 王晓燕, 张丽丽, 等. 健康儿童脂溶性维生素A、D、E现状分析[J]. 中华临床营养杂志,2016,24(6):349-353. doi: 10.3760/cma.j.issn.1674-635X.2016.06.005
[22]	蒋益忠, 夏天爽, 辛海量, 等. 维生素K对成骨细胞骨形成和破骨细胞骨吸收的影响[J]. 药学实践杂志,2020,38(4):340-345.
[23]	王倩, 赵莉, 武艳梅, 等. 盘锦市0~6岁儿童骨密度调查及其与血清维生素K的关系研究[J]. 中国实用医药,2020,15(25):164-165.
[24]	于雪, 王明月, 赵雪, 等. 血清维生素A、维生素D、维生素K水平与营养性矮身材(脾气虚证)的相关性研究[J]. 中医药导报,2020,26(14):64-66.

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