Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension

Jin-hong LI; Hong WANG

doi:10.12259/j.issn.2095-610X.S20210410

Volume 42 Issue 4

Apr. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(4): 53-56

Jin-hong LI, Hong WANG. Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension[J]. Journal of Kunming Medical University, 2021, 42(4): 53-56. doi: 10.12259/j.issn.2095-610X.S20210410

Citation:

Jin-hong LI, Hong WANG. Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension[J]. Journal of Kunming Medical University, 2021, 42(4): 53-56. doi: 10.12259/j.issn.2095-610X.S20210410

Citation:

Jin-hong LI, Hong WANG. Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension[J]. Journal of Kunming Medical University, 2021, 42(4): 53-56. doi: 10.12259/j.issn.2095-610X.S20210410

PDF( 594 KB)

Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension

doi: 10.12259/j.issn.2095-610X.S20210410

Jin-hong LI¹,
Hong WANG^{2
,
,}

1.
Dept. of Pharmacy，Tieling City Central Hospital，Tieling Liaoning 112000
2.
Dept. of Endocrinology，The 1st Affiliated Hospital of China Medical University， Shenyang Liaoning 110001，China

Received Date: 2020-12-23
Publish Date: 2021-04-25

Abstract

Abstract

Objective To analyze the clinical efficacy and safety of valsartan amlodipine tablets combined with alpha-lipoic acid in the treatment of elderly type 2 diabetic nephropathy complicated with hypertension. Methods A total of 40 elderly patients with type 2 diabetic nephropathy complicated with hypertension who were admitted to the First Affiliated Hospital of China Medical University from February 2018 to August 2019 were enrolled in this study. They were divided into control group and observation group by pairing method. In the control group （n = 20）, there were 13 males and 7 females with an average age of （64.24±1.16）. In the observation group （n = 20）, there were 11 males and 9 females with an average age of （65.12±1.12）. Patients in both groups received routine hypoglycemic therapy, the control group was treated with valsartan and amlodipine tablets, and the observation group was treated with valsartan and amlodipine tablets combined with α-lipoic acid. Diastolic blood pressure （DBP）, systolic blood pressure （SBP）, Urinary albumin excretion rate （UAER）, blood nitrogen （BUN）, serum creatinine （SCR） and adverse reactions were compared between the observation group and the control group before and after treatment. Results The SBP, DBP, UAER and adverse reactions in the observation group were lower than those in the control group, and the efficacy and safety of the treatment were better than those in the control group with single drug （valsartan amlodipine tablet）, the difference was statistically significant （P < 0.05）. Conclusion Compared with valsartan amlodipine tablets alone, valsartan amlodipine tablets have better therapeutic effect, more stable, better safety and better patient satisfaction degree after two months of treatment, which is worthy of to long-term clinical application and promotion.
- Senile type 2 diabetic nephropathy complicated with hypertension,
- Valsartan amlodipine tablets,
- α-lipoic acid,
- Treatment effect

FullText(HTML)

References(15)

References

[1]	Felício J S,De Souza A C,Kohlmann N,et al. Clinical efficacy of nifedipine controlled release tablet and valsartan in the treatment of type 2 diabetic nephropathy and hypertension of elderly patients[J]. Chin General Pract,2012,15(7C):2439-2441.
[2]	张静. 探讨厄贝沙坦与钙离子拮抗剂联合用于老年2型糖尿病肾病合并高血压的治疗效果[J]. 中国现代药物应用,2017,11(22):97-98.
[3]	黄超岚. 卡托普利联合硝苯地平治疗原发性高血压合并2型糖尿病尿微量白蛋白的临床观察[J]. 中国药房,2018,22(16):1470-1472.
[4]	王芹. 氯沙坦联合硝苯地平对老年2型糖尿病肾病合并高血压患者肾功能的影响[J]. 中国药业,2016,21(8):38-39.
[5]	罗天惠,段正素. 老年2型糖尿病肾病合并高血压厄贝沙坦与钙离子拮抗剂联合应用的治疗效果及对肾功能的保护作用[J]. 心理医生,2017,23(6):12-13.
[6]	潘佳秋,王慧慧,张超,等. 新诊断2型糖尿病患者血清视黄醇结合蛋白4和游离脂肪酸水平变化及其与胰岛素敏感性的关系研究[J]. 中国全科医学,2017,14(21):2370-2372.
[7]	王东娜,王旭梅. 厄贝沙坦联合钙离子拮抗剂治疗老年2型糖尿病肾病合并高血压的效果分析[J]. 中国实用医药,2019,14(21):101-102.
[8]	艾冠男,王兆丰,杨晓旭,等. 老年高血压前期患者临床特点及高盐饮食对其预后影响[J]. 临床军医,2019,7(5):466-471.
[9]	郭玫. 不同性别老年人2型糖尿病患者的生活质量及影响因素[J]. 中国老年学,2020,12(23):5106-5111.
[10]	丁少玉,鞠昌萍. 进餐顺序在糖尿病病人饮食治疗中的进展研究[J]. 护理研究,2020,12(23):4199-4202. doi: 10.12102/j.issn.1009-6493.2020.23.017
[11]	夏碧荣,公振宇. 缬沙坦联合氨氯地平与缬沙坦联合氢氯噻嗪治疗老年高血压患者的效果研究[J]. 中国社区医师,2021,37(9):61-62. doi: 10.3969/j.issn.1007-614x.2021.09.030
[12]	孔庆琳. 缬沙坦联合福辛普利钠与氨氯地平治疗高血压合并轻度认知功能障碍的疗效观察[J]. 当代医学,2021,27(9):128-130. doi: 10.3969/j.issn.1009-4393.2021.09.049
[13]	向会,傅明强,周巍. 缬沙坦氨氯地平片联合辛伐他汀治疗老年高血压合并血脂异常患者的疗效及血清学变化分析[J]. 中国现代医生,2021,59(5):125-128.
[14]	张红娥,王树鲜. 缬沙坦与氨氯地平联合治疗社区老年原发性高血压合并糖尿病患者的临床效果研究[J]. 中国实用医药,2021,16(2):19-21.
[15]	何晓玮,钟涛. α硫辛酸辅助奥美沙坦酯对糖尿病肾病患者血清miR-150-5p及miR-155-5p表达的影响[J]. 中国现代应用药学,2021,38(5):624-629.

Relative Articles(20)

Relative Articles

[1]	Limei HE, Xuemin FENG, Linjun LI, Ying CHEN, Zexing YANG. Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment. Journal of Kunming Medical University, 2024, 45(1): 73-77. doi: 10.12259/j.issn.2095-610X.S20240106
[2]	Zhenxing YUAN, Wenfei SUN, Weidong WANG. Relationship between hs-CRP，CCL2，CCL3 and Neonatal Bacterial Infection and Their Predictive Value for Efficacy. Journal of Kunming Medical University, 2024, 45(7): 1-7.
[3]	Xiaofeng ZHU, Guangping ZHOU, Laicang WANG, Houjun ZHOU, Xin GENG, Hualin YU, Jinghui LI, Peng BAI. Clinical Effect of Reoperation for Recurrent Glioma. Journal of Kunming Medical University, 2022, 43(9): 77-83. doi: 10.12259/j.issn.2095-610X.S20220920
[4]	Zhang Ti Ling , Zhang Wei Hua , Luo Qing 祎, Xia Hong Ying , Lu Yi Bing . . Journal of Kunming Medical University, 2020, 41(03): 91-95.
[5]	Ye Ji Ming , Gu Xue Zhong , Chu Yu Yan , Liu Yu , Ye Ji Yun . . Journal of Kunming Medical University, 2020, 41(03): 72-76.
[6]	Rong WAN, Ming-wu LI, Meng MA, Ming-hong LAI, Guang-mei Li. Efficacy of T-SPOT.TB in Treatment of Active Tuberculosis. Journal of Kunming Medical University, 2020, 41(12): 133-137. doi: 10.12259/j.issn.2095-610X.S20201237
[7]	Sun Yu Peng , Zhang Chun Qiang , Du Kai Li , He Shao Bo , Guo Pei Yu , Zhao Run Min . The Value of T-SPOT.TB in Evaluating Treatment Effect of Tuberculous Vertebral Osteomyelitis. Journal of Kunming Medical University, 2018, 39(06): 86-90.
[8]	Wang Rong Hua , Gu Ying , Fang Xia Ling . The Influence of Family Nursing Intervention on Treatment Effect and Quality of Life among Asthmatic Children. Journal of Kunming Medical University, 2018, 39(06): 144-148.
[9]	Fu Zhong Yang , Yi Jing . Clinical Observation of Treatment of Hypertension and Coronary Heart Disease with Amlodipine Atorvastatin Calcium Tablet. Journal of Kunming Medical University, 2017, 38(10): 117-119.
[10]	Wang Xu , Guo Qing Hua , Zhu Xiao Pu , Zhu Xiao Yan , Yang Ming . Effect of Endoscopic Sinus Surgery on Paranasal Sinus Fungus Balls. Journal of Kunming Medical University, 2016, 37(12): 47-50.
[11]	Xiao Yi . The Clinical Effect of CDSP Treatment for Coronary Heart Disease. Journal of Kunming Medical University,
[12]	Tang Shi Cong . . Journal of Kunming Medical University,
[13]	Zhang Wen Yan . . Journal of Kunming Medical University,
[14]	Fu Zhong Yang . . Journal of Kunming Medical University,
[15]	Yang Ying . . Journal of Kunming Medical University,
[16]	Yang Ying . . Journal of Kunming Medical University,
[17]	Jin Shi Jun . . Journal of Kunming Medical University,
[18]	Guo Xue Song . . Journal of Kunming Medical University,
[19]	Chen Guan Fen . Clinical Significance of Serum Procalcitonin Levels in Optimizing Antibiotic Therapy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University,
[20]	. Protective Effect of α-Thioctic Acid on Early Type 2 Diabetics Nephropathy. Journal of Kunming Medical University,