Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension

Jin-hong LI; Hong WANG

doi:10.12259/j.issn.2095-610X.S20210410

Volume 42 Issue 4

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(4): 53-56

Jin-hong LI, Hong WANG. Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension[J]. Journal of Kunming Medical University, 2021, 42(4): 53-56. doi: 10.12259/j.issn.2095-610X.S20210410

Citation:

Jin-hong LI, Hong WANG. Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension[J]. Journal of Kunming Medical University, 2021, 42(4): 53-56. doi: 10.12259/j.issn.2095-610X.S20210410

Citation:

Jin-hong LI, Hong WANG. Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension[J]. Journal of Kunming Medical University, 2021, 42(4): 53-56. doi: 10.12259/j.issn.2095-610X.S20210410

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Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension

doi: 10.12259/j.issn.2095-610X.S20210410

Jin-hong LI¹,
Hong WANG^{2
,
,}

1.
Dept. of Pharmacy，Tieling City Central Hospital，Tieling Liaoning 112000
2.
Dept. of Endocrinology，The 1st Affiliated Hospital of China Medical University， Shenyang Liaoning 110001，China

Received Date: 2020-12-23
Publish Date: 2021-04-25

Abstract

Abstract

Objective To analyze the clinical efficacy and safety of valsartan amlodipine tablets combined with alpha-lipoic acid in the treatment of elderly type 2 diabetic nephropathy complicated with hypertension. Methods A total of 40 elderly patients with type 2 diabetic nephropathy complicated with hypertension who were admitted to the First Affiliated Hospital of China Medical University from February 2018 to August 2019 were enrolled in this study. They were divided into control group and observation group by pairing method. In the control group （n = 20）, there were 13 males and 7 females with an average age of （64.24±1.16）. In the observation group （n = 20）, there were 11 males and 9 females with an average age of （65.12±1.12）. Patients in both groups received routine hypoglycemic therapy, the control group was treated with valsartan and amlodipine tablets, and the observation group was treated with valsartan and amlodipine tablets combined with α-lipoic acid. Diastolic blood pressure （DBP）, systolic blood pressure （SBP）, Urinary albumin excretion rate （UAER）, blood nitrogen （BUN）, serum creatinine （SCR） and adverse reactions were compared between the observation group and the control group before and after treatment. Results The SBP, DBP, UAER and adverse reactions in the observation group were lower than those in the control group, and the efficacy and safety of the treatment were better than those in the control group with single drug （valsartan amlodipine tablet）, the difference was statistically significant （P < 0.05）. Conclusion Compared with valsartan amlodipine tablets alone, valsartan amlodipine tablets have better therapeutic effect, more stable, better safety and better patient satisfaction degree after two months of treatment, which is worthy of to long-term clinical application and promotion.
- Senile type 2 diabetic nephropathy complicated with hypertension,
- Valsartan amlodipine tablets,
- α-lipoic acid,
- Treatment effect

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References(15)

References

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