Effect of Plasma Exchange with Double Plasma Molecular Adsorption on Cytokines in Autoimmune Hepatitis with Liver Failure

Wei-sha ZHOU; Le ZHANG; Jing PENG; Shou-kun CHEN; Meng-jun LIU; Xiao FU; Zhi-fei TANG; Yun-xuan YUE

doi:10.12259/j.issn.2095-610X.S20210414

Volume 42 Issue 4

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(4): 73-77

Wei-sha ZHOU, Le ZHANG, Jing PENG, Shou-kun CHEN, Meng-jun LIU, Xiao FU, Zhi-fei TANG, Yun-xuan YUE. Effect of Plasma Exchange with Double Plasma Molecular Adsorption on Cytokines in Autoimmune Hepatitis with Liver Failure[J]. Journal of Kunming Medical University, 2021, 42(4): 73-77. doi: 10.12259/j.issn.2095-610X.S20210414

Citation:

Wei-sha ZHOU, Le ZHANG, Jing PENG, Shou-kun CHEN, Meng-jun LIU, Xiao FU, Zhi-fei TANG, Yun-xuan YUE. Effect of Plasma Exchange with Double Plasma Molecular Adsorption on Cytokines in Autoimmune Hepatitis with Liver Failure[J]. Journal of Kunming Medical University, 2021, 42(4): 73-77. doi: 10.12259/j.issn.2095-610X.S20210414

Citation:

Wei-sha ZHOU, Le ZHANG, Jing PENG, Shou-kun CHEN, Meng-jun LIU, Xiao FU, Zhi-fei TANG, Yun-xuan YUE. Effect of Plasma Exchange with Double Plasma Molecular Adsorption on Cytokines in Autoimmune Hepatitis with Liver Failure[J]. Journal of Kunming Medical University, 2021, 42(4): 73-77. doi: 10.12259/j.issn.2095-610X.S20210414

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Effect of Plasma Exchange with Double Plasma Molecular Adsorption on Cytokines in Autoimmune Hepatitis with Liver Failure

doi: 10.12259/j.issn.2095-610X.S20210414

Blood Purification Center of the Third People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2020-12-29
Publish Date: 2021-04-01

Abstract

Abstract

Objective To study the effect of Plasma Exchange （PE） combined with Double Plasma Molecular Absorption System （DPMAS） on cytokines in patients with autoimmune hepatitis complicated with liver failure, and to explore the significance of Plasma Exchange combined with Double Plasma Molecular absorption in immunotherapy and the impact on the prognosis of such patients. Methods In this study, 22 patients with autoimmune hepatitis complicated with liver failure who were hospitalized in the Third People’ s Hospital of Kunming City from October 2017 to August 2020 were selected. These patients received plasma exchange combined with double plasma molecular adsorption therapy, and the changes of cytokines （IL-2, IL-4, IL-6, IL-10, TNF-α）, liver function, blood ammonia, coagulation function, blood routine and other indicators before and after the combined medical treatment were analyzed. Results After treatment, the levels of cytokines IL-2, IL-6, and TNF-α, liver function （TBil, AST, ALT, ALB）, blood ammonia, prothrombin activity, hemoglobin, platelet decreased significantly, （P < 0.05）; while the differences in cytokines IL-4 and IL-10）, total bile acid and other indicators were statistically insignificant （P > 0.05）. Conclusion Selective plasma exchage combined with double plasma molecular adsorption in the treatment of patients with autoimmune hepatitis complicated with liver failure helps to maintain homeostasis and supports the regeneration of liver cells, so as to restore liver function and improve clinical symptoms such as jaundice. This method can improve the survival rate of patients, improve the success rate of liver failure treatment, and is worthy of clinical promotion.
- Plasmapheresis,
- Double plasma molecular adsorption,
- Autoimmune hepatitis,
- Liver failure,
- Cytokines

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References(22)

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