Clinical Characteristics and Serum Levels of Endoplasmic Reticulum Stress Factors HSP47, XBP-1S and GRP78 in Elderly Women with Acute Myocardial Infarction

Ni-ni TIAN; Hong-qing ZHANG; Min TIAN; Cai-ping LV; Bin YANG; Feng XU; Hong-jian LI; Xing-hua PAN

doi:10.12259/j.issn.2095-610X.S20210417

Volume 42 Issue 4

Apr. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(4): 91-95

Ni-ni TIAN, Hong-qing ZHANG, Min TIAN, Cai-ping LV, Bin YANG, Feng XU, Hong-jian LI, Xing-hua PAN. Clinical Characteristics and Serum Levels of Endoplasmic Reticulum Stress Factors HSP47, XBP-1S and GRP78 in Elderly Women with Acute Myocardial Infarction[J]. Journal of Kunming Medical University, 2021, 42(4): 91-95. doi: 10.12259/j.issn.2095-610X.S20210417

Citation:

Ni-ni TIAN, Hong-qing ZHANG, Min TIAN, Cai-ping LV, Bin YANG, Feng XU, Hong-jian LI, Xing-hua PAN. Clinical Characteristics and Serum Levels of Endoplasmic Reticulum Stress Factors HSP47, XBP-1S and GRP78 in Elderly Women with Acute Myocardial Infarction[J]. Journal of Kunming Medical University, 2021, 42(4): 91-95. doi: 10.12259/j.issn.2095-610X.S20210417

Citation:

Ni-ni TIAN, Hong-qing ZHANG, Min TIAN, Cai-ping LV, Bin YANG, Feng XU, Hong-jian LI, Xing-hua PAN. Clinical Characteristics and Serum Levels of Endoplasmic Reticulum Stress Factors HSP47, XBP-1S and GRP78 in Elderly Women with Acute Myocardial Infarction[J]. Journal of Kunming Medical University, 2021, 42(4): 91-95. doi: 10.12259/j.issn.2095-610X.S20210417

PDF( 639 KB)

Clinical Characteristics and Serum Levels of Endoplasmic Reticulum Stress Factors HSP47, XBP-1S and GRP78 in Elderly Women with Acute Myocardial Infarction

doi: 10.12259/j.issn.2095-610X.S20210417

1.
Dept. of Cardiology
2.
Dept. of Laboratory，Ganmei Hospital Affiliated to Kunming Medical University，Kunming Yunnan 650011
3.
Teaching and Research Office，Kunhua Hospital of Kunming University of Science and Technology
4.
Clinical Laboratory，No. 920 Hospital，Joint Support Unit，Kunming Yunnan 650032，China

Received Date: 2021-01-16
Publish Date: 2021-04-01

Abstract

Abstract

Objective To investigate the clinical characteristics of female patients with myocardial infarction and the differences in serum levels of endoplasmic reticulum stress proteins HSP47, XBP-1S, and GRP78 with male patients. Methods A total of 356 patients with acute myocardial infarction who were admitted to the hospital. The venous blood was collected within 24 hours after the onset, and the serum HSP47, XBP-1S and GRP78 concentrations were measured after centrifugation. They were divided into female group （n = 116） and male group （n = 240）. The independent sample t test, chi-square test and nonparametric rank sum test were used for clinical data analysis. Results The age of onset in the female group was older than that in the male group （P < 0.05）; while the prevalence of smoking and hypertension in the female group were lower than those in the male group （P < 0.05）. The level of XBP-1S in serum of female patients was higher than that of male patients （P = 0.023, P < 0.05）; but there was no significant difference in serum HSP47 and GRP78 levels between female patients and male patients （P > 0.05）. Serum GLU and BNP levels in the female patient group were higher than those in the male patient group （both P < 0.05）, and the female patient group had lower levels of HCY （mmol/L）, CREA （mmol/L）, uric acid （mmol/L） and eGFRm than in the male group （all P < 0.05）. The incidence of non-ST-segment elevation myocardial infarction was 47.4% higher than that of the male group （P < 0.05）. Conclusion Female patients with acute myocardial infarction have an older age of onset, higher serum GLU and BNP levels. The incidence of non-ST segment elevation myocardial infarction is higher in the female group and higher endoplasmic reticulum stress protein XBP-1S level within 24 hours of onset; while the serum levels of HCY, CREA, uric acid, and eGFRm in male patients with acute myocardial infarction were higher than those in the female group.
- Acute myocardial infarction,
- Female,
- Endoplasmic reticulum stress,
- X-box blinding protein

FullText(HTML)

References(17)

References

[1]	葛均波, 徐永健, 王辰. 内科学[M]. 第9版. 北京: 人民卫生出版社, 2018: 213-214.
[2]	A. A. Knowlton,D. H. Korzick. Estrogen and the Female Heart[J]. Mol Cell Endocrinol,2014,389(1-2):31-39. doi: 10.1016/j.mce.2014.01.002
[3]	张冬. 绝经前冠心病发病机制研究进展综述[J]. 中国循环杂志,2016,27(5):397-398.
[4]	张云雁,吴翔. 女性急性心肌梗死的特点和研究进展[J]. 东南国防医药,2018,20(3):276-280. doi: 10.3969/j.issn.1672-271X.2018.03.013
[5]	Brilakis E S,Mc Connell J P,Lennon R J,et al. Association of lipoprpteinassociated phosphplipase A2 levels with coronary artery disease risk factor,angiographic coronary artery disease,and major advers enents at follow-up[J]. Arch Iran Med,2013,16(3):161-166.
[6]	胡新科,李佳丹,李振凤. 绝经前女性急性心肌梗死患者临床特点分析[J]. 中国循证心血管医学杂志,2016,8(11):1361-1363. doi: 10.3969/j.issn.1674-4055.2016.11.22
[7]	李火银. 组织选择性雌激素对围绝经期女性冠心病预防效果研究[J]. 中国妇幼保健,2016,31(23):5088-5091.
[8]	李文文,马丽萍,秦永文,等. 老年急性心肌梗死患者死亡及危险因素的回顾性分析[J]. 中华老年多器官疾病杂志,2014,13(1):49-53.
[9]	田倪妮,杨俊,田敏,等. 急性心肌梗死患者血清caspase-12表达水平的影响因素[J]. 临床心血管病杂志,2019,35(1):35-38.
[10]	王佳玉,王德昭,陈威,等. 女性急性ST段抬高型心肌梗死患者的临床特点[J]. 中国心血管病杂志,2017,22(5):332-336.
[11]	田倪妮,田敏,杨俊,等. 急性心肌梗死患者血清Caspase-12酶活性、CHOP蛋白、HSP47表达水平与冠状动脉病变的相关性研究[J]. 临床心血管病杂志,2019,35(7):631-633.
[12]	李爱琴,张君,徐文静,等. GRP78在正常与肥胖女性患者内膜脂肪组织中表达水平的比较研究[J]. 中国糖尿病杂志,2012,20(9):657-659.
[13]	朱平均,周浩,胡舜英,等. 内质网应激参与调节心肌缺血/再灌注损伤研究的新进展[J]. 中华老年多器官疾病杂志,2017,16(3):225-229. doi: 10.11915/j.issn.1671-5403.2017.03.052
[14]	Zeng L F,Zampetaki A,Margariti A,at al. Sustained activation of XBP-1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow[J]. Proc Natl Acad Sci U S A,2009,106(20):8326-8331. doi: 10.1073/pnas.0903197106
[15]	丁丽华,叶棋浓,严景华,等. XBP-1和ERα存在相互作用[J]. 生物工程学报,2004,20(3):332-336. doi: 10.3321/j.issn:1000-3061.2004.03.004
[16]	张霞丽,万福生. X-盒结合蛋白1的生理及病理生理学作用[J]. 基础医学与临床,2011,31(11):1289-1292.
[17]	田倪妮,朱向情,杨林,等. 急性心肌梗死患者血清中剪切型X-盒结合蛋白1表达与糖尿病及其他临床因素的相关性[J]. 心脏杂志,2020,32(2):128-134.

Relative Articles(20)

Relative Articles

[1]	Xiaodong ZHU, Yanlong LIU, Xu ZHOU, Hailong DAI, Xiaolong YIN. Value of cMyBP-C in Clinical Diagnosis of Acute Myocardial Infarction. Journal of Kunming Medical University, 2023, 44(3): 97-102. doi: 10.12259/j.issn.2095-610X.S20230328
[2]	Di HE, Peng CHEN, Feng LIU, Yang XU, Lei HAN, Wenjing DING. Progress in Etiology and Pathogenesis of Liver Fibrosis. Journal of Kunming Medical University, 2022, 43(11): 165-171. doi: 10.12259/j.issn.2095-610X.S20221122
[3]	Wenqing MIAO, Yu WANG, Xiaoli ZHAO, Nini TIAN, Liying YOU. Analysis of Differential Gene Expression and Function in Peripheral Blood of Patients with Coronary Heart Disease and Acute Myocardial Infarction. Journal of Kunming Medical University, 2022, 43(6): 25-34. doi: 10.12259/j.issn.2095-610X.S20220614
[4]	Chen WANG, Sha LI, Boxue ZHANG, Jinhua HE. Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females. Journal of Kunming Medical University, 2022, 43(9): 135-140. doi: 10.12259/j.issn.2095-610X.S20220907
[5]	Li ZHANG, Qingcen WANG, Luohui ZHOU, Juan YANG, Hong WANG. Luteolin Inhibits HASMCs Migration by Endoplasmic Reticulum Stress. Journal of Kunming Medical University, 2022, 43(5): 12-17. doi: 10.12259/j.issn.2095-610X.S20220518
[6]	Yin ZHANG, Li-xia YANG, Yan CHEN, Jia-xua HE. Effect of Establishment of Chest Pain Center on the Treatment Efficiency of Acute Myocardial Infarction. Journal of Kunming Medical University, 2021, 42(6): 88-93. doi: 10.12259/j.issn.2095-610X.S20210644
[7]	Zhen-lin XIE, Ya-jian FENG, Zhi-wei FAN, Dong-xing ZHANG. Expression and Significance of CARP, Myo and α1-microglobulin in Serum of Patients with Acute Myocardial Infarction. Journal of Kunming Medical University, 2021, 42(11): 128-132. doi: 10.12259/j.issn.2095-610X.S20211123
[8]	Luo Lin Ping , Liu Ming Yan , Wu Xiang , Nie Lei . Correlation between ECG Changes and Coronary Angiography of Acute Myocardial Infarction. Journal of Kunming Medical University, 2017, 38(01): 113-116.
[9]	Lan Jian Jun , Wang Lin , Wang Shi Hai , Zeng Xiao Bin , Xu Da Wen , Wen Hua Zhi . . Journal of Kunming Medical University, 2017, 38(03): 47-50.
[10]	Qu Qi Cai . Azasetron for Prophylaxis of Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy in Female Patients at Menstrual Phase. Journal of Kunming Medical University,
[11]	Gao Ju Ling . . Journal of Kunming Medical University,
[12]	Wu Jian . . Journal of Kunming Medical University,
[13]	Yang Qiong Hui . . Journal of Kunming Medical University,
[14]	Du Juan . . Journal of Kunming Medical University, 2015, 36(04): 1-1.
[15]	Chen Ting Jie . . Journal of Kunming Medical University,
[16]	Pang Ming Jie . . Journal of Kunming Medical University,
[17]	. The Analysis of Blood Lipids in Patients with Acute Myocardial Infarction. Journal of Kunming Medical University,
[18]	. Clinical Study of Relationship between Acute Myocardial Infarction and Plasma Levels of cTnI, BNP and CRP. Journal of Kunming Medical University,
[19]	. . Journal of Kunming Medical University,
[20]	Zhao Xue Ying . . Journal of Kunming Medical University,