Retrospective Analysis of 376 Cases of Adverse Reactions to Antituberculosis Drug

Na LI; Jie CHEN; Ji LUO; Yong-gang CHEN; Jiang-li PENG; Ming-li YU; Sheng-hao LI

doi:10.12259/j.issn.2095-610X.S20210422

Volume 42 Issue 4

Apr. 2021

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Na LI, Jie CHEN, Ji LUO, Yong-gang CHEN, Jiang-li PENG, Ming-li YU, Sheng-hao LI. Retrospective Analysis of 376 Cases of Adverse Reactions to Antituberculosis Drug[J]. Journal of Kunming Medical University, 2021, 42(4): 117-121. doi: 10.12259/j.issn.2095-610X.S20210422

Citation:

Na LI, Jie CHEN, Ji LUO, Yong-gang CHEN, Jiang-li PENG, Ming-li YU, Sheng-hao LI. Retrospective Analysis of 376 Cases of Adverse Reactions to Antituberculosis Drug[J]. Journal of Kunming Medical University, 2021, 42(4): 117-121. doi: 10.12259/j.issn.2095-610X.S20210422

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Retrospective Analysis of 376 Cases of Adverse Reactions to Antituberculosis Drug

doi: 10.12259/j.issn.2095-610X.S20210422

1.
Dept. of Pharmacy
2.
Dept. of Liver Disease，The Third People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2020-12-11
Publish Date: 2021-04-01

Abstract

Abstract

Objective To explore the specific types, occurrence time and age structure of adverse reaction （ADR） in tuberculosis patients after anti-tuberculosis treatment, so as to provide certain reference for rational, safe and effective drug use in clinical practice. Methods The data of 376 patients with adverse reactions due to antituberculosis drugs admitted to Kunming Third People’ s Hospital from January 2015 to December 2019 were collected, and the data were analyzed using SPSS software. Results The occurrence of ADR in patients after anti-tuberculosis treatment was mostly likely to occur in the first 10 days, and the incidence of ADR in males was higher than that in females, but the difference was not statistically significant. The incidence of hepatotoxicity in TB patients after taking rifampicin （RFP） and isoniazid （INH） was higher （P < 0.05）, and the incidence of hyperuricemia in TB patients after taking pyrazinamide （PZA） was higher （P < 0.05）. The incidence of pruritus was higher in patients taking ethambutol （EMB）（P < 0.05）. Conclusion ADRs caused by antituberculosis drugs are mostly hyperuricemia, pruritus, rash, liver damage, etc. Patients may develop ADRs within 10 days of initial dose. Therefore, clinicians should pay special attention to high-risk groups to reduce the occurence of ADR after medication.
- Pulmonary tuberculosis,
- Antituberculosis therapy,
- Individualized administration,
- Adverse reactions

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References(20)

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