Comparison of the Efficacy of Ommaya Reservoir and Lumbar Cistern Intervention of Tuberculous Meningoencephalitis Complicated with Hydrocephalus

Guo-ji CHANG; Ying HUANG; Yan-ling ZHANG; Hua HE; Jun XU; Yang LI

doi:10.12259/j.issn.2095-610X.S20210423

Volume 42 Issue 4

Apr. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(4): 122-127

Guo-ji CHANG, Ying HUANG, Yan-ling ZHANG, Hua HE, Jun XU, Yang LI. Comparison of the Efficacy of Ommaya Reservoir and Lumbar Cistern Intervention of Tuberculous Meningoencephalitis Complicated with Hydrocephalus[J]. Journal of Kunming Medical University, 2021, 42(4): 122-127. doi: 10.12259/j.issn.2095-610X.S20210423

Citation:

Guo-ji CHANG, Ying HUANG, Yan-ling ZHANG, Hua HE, Jun XU, Yang LI. Comparison of the Efficacy of Ommaya Reservoir and Lumbar Cistern Intervention of Tuberculous Meningoencephalitis Complicated with Hydrocephalus[J]. Journal of Kunming Medical University, 2021, 42(4): 122-127. doi: 10.12259/j.issn.2095-610X.S20210423

Citation:

Guo-ji CHANG, Ying HUANG, Yan-ling ZHANG, Hua HE, Jun XU, Yang LI. Comparison of the Efficacy of Ommaya Reservoir and Lumbar Cistern Intervention of Tuberculous Meningoencephalitis Complicated with Hydrocephalus[J]. Journal of Kunming Medical University, 2021, 42(4): 122-127. doi: 10.12259/j.issn.2095-610X.S20210423

PDF( 618 KB)

Comparison of the Efficacy of Ommaya Reservoir and Lumbar Cistern Intervention of Tuberculous Meningoencephalitis Complicated with Hydrocephalus

doi: 10.12259/j.issn.2095-610X.S20210423

Dept. of Infectious Diseases，The 3rd People’s Hospital，Kunming Yunnan 650041，China

Received Date: 2020-12-16
Publish Date: 2021-04-25

Abstract

Abstract

Objective To investigate the clinical efficacy of cerebrospinal fluid drainage and injection by Ommaya reservoir implantation and lumbar cistern intervention in the treatment of patients of tuberculous meningoencephalitis with hydrocephalus. Methods A total of 50 patients with tuberculous meningoencephalitis with hydrocephalus in our hospital from March 2017 to September 2018 participated in this study. Participants were divided into 3 groups: control group, Ommaya reservoir group and lumbar cistern intervention group. The control group received routine antituberculosis; Ommaya reservoir group received routine antituberculous therapy combined with cerebrospinal fluid drainage and lateral ventricle injection; and lumbar cistern intervention group received anti-tuberculosis treatment combined with lumbar cistern cerebrospinal fluid drainage and intrathecal injection. The treatment duration was 4 weeks. The efficacy and adverse reactions of the three groups were compared and analyzed. Results The clinical symptom remission time of Ommaya reservoir group and lumbar cistern intervention group was shorter than that of control group （P < 0.05）. The intracranial pressure at 3 days, 1 week, 2 weeks and 4 weeks after treatment was significantly different from that before treatment （ P < 0.05）. Compared with the control group, there were statistically significant differences in the cerebrospinal fluid biochemical indexes in the lumbar cistern intervention group and the Ommaya reservoir group after 1 week of treatment （ P < 0.05）. 2 months after treatment, the absorption of intracranial lesions in the Ommaya reservoir group was significantly higher than that in the other two groups （ P < 0.05）. The total effective rates of the control group, the lumbar cistern intervention group and the Ommaya reservoir group were 45%, 83.3% and 100%, respectively （ P < 0.05）. Conclusion The interventional treatment of tuberculous meningoencephalitis with hydrocephalus by lumbar cistern catheterization and Ommaya reservoir implant can relieve the clinical symptoms, reduce intracranial pressure and improve the biochemical indexes of cerebrospinal fluid in a short time. Interventional therapy via the Ommaya reservoir approach promotes the absorption of intracranial lesions more effectively than interventional therapy via the lumbar cistern.
- Lumbar cistern,
- Ommaya reservoir,
- Interventional treatment,
- Tuberculous meningoencephalitis with hydrocephalus

FullText(HTML)

References(15)

References

[1]	吴素方,梁丽丽,郑淑兰,等. 利奈唑胺治疗重症结核性脑膜炎的疗效观察[J]. 河南预防医学杂志,2019,30(9):719-721.
[2]	Pasco P M. Diagnostic features of tuberculous meningitis:A cross-sectional study[J]. Bmc Res Notes.,2012,5(1):1-6. doi: 10.1186/1756-0500-5-1
[3]	Harsimran K. Prospective analysis of 55 cases of tuberculosis meningitis(TBM)in north india[J]. Journal of Clinical and Diagnostic Research(JCDR),2015,1(9):15-19.
[4]	闫红梅,兰小艳,顾燕梅,等. 鞘内注射联合脑脊液置换治疗结核性脑膜炎的效果观察[J]. 宁夏医学杂志,2018,40(6):528-530.
[5]	柳兴军,黄玉宝,陈子祥. 腰大池置管持续引流联合鞘内注射给药治疗结核性脑膜炎患者疗效[J]. 中国老年学杂志,2015,35(9):2488-2490.
[6]	曾文高. 脑脊液置换联合鞘内注射药物治疗结核性脑膜炎效果观察[J]. 临床合理用药杂志,2020,13(32):33-35.
[7]	邱修辉. Ommaya囊植入术在原发性颅内感染并脑积水治疗中的应用分析[J]. 浙江临床医学,2015,17(4):581-582.
[8]	Wilkinson R J,Rohlwink U,Misra U K,et al. Tuberculous meningitis[J]. Nature Reviews Neurology,2017,13(10):581-598. doi: 10.1038/nrneurol.2017.120
[9]	Angharad Grace,Davis . Thepathogenesis of tuberculous meningitis.[J]. Journal of Leukocyte Biology,2019,105(2):267-280. doi: 10.1002/JLB.MR0318-102R
[10]	夏衣扎提·库尔曼. 腰大池置管持续引流联合鞘内注射给药治疗结核性脑膜炎患者疗效探究[J]. 中国实用医药,2016,11(26):225-226.
[11]	Anne Ferrel,Fmclaughlin J,Agrant G,et al. Long-term safety and efficacy of continuous intrathecal baclofen[J]. Journal of Developmental & Behavioral Pediatrics,2010,44(10):660-665.
[12]	李伟,王勇. 腰大池置管引流在结核性脑膜炎治疗中的应用效果[J]. 中国继续医学教育,2019,11(4):92-94.
[13]	周放. 莫西沙星联合抗结核药物治疗难治性结核性脑膜炎的疗效评价[J]. 北方药学,2018,15(4):105.
[14]	范鹏辰,王志祺,赖辉. 异烟肼及地塞米松鞘内注射治疗对结核性脑膜炎病人脑脊液中炎性因子及IgA、IgG水平的影响[J]. 中西医结合心脑血管病杂志,2019,17(3):439-443.
[15]	叶蕾,杨小红,孙小娟. 1例行 OMMAYA 囊置入侧脑室外引流术后结核性脑膜脑炎患儿的护理[J]. 实用临床医药杂志,2014,18(14):162-164.

Relative Articles(20)

Relative Articles

[1]	Xinbang WANG, An HU, Xipeng ZHAO, Yan WANG, Wei DING, Lipeng CAO, Yu GU, Ke XU, Yunfeng ZHANG. Effect of Ommaya Capsule on Cerebral Hemorrhage Complicated with Acute Hydrocephalus and its Effect on Blood-brain Barrier Function. Journal of Kunming Medical University, 2024, 45(10): 96-104. doi: 10.12259/j.issn.2095-610X.S20241015
[2]	Xi GUO, Xiaoqing TANG, Jie WANG, Yan WAN, Bin XU, Yu LUO. Effect of Early Interventional Palliative Treatment on Pain and Anxiety in Patients with Hepatitis-Related Liver Cancer. Journal of Kunming Medical University, 2022, 43(8): 93-99. doi: 10.12259/j.issn.2095-610X.S20220813
[3]	Lai 碁, Guang Xue Feng , Ru Zhi Gang , Lin Xiao Feng , Jing Shu Nan , Fang Jie . . Journal of Kunming Medical University, 2019, 40(04): 61-65.
[4]	Liu Xin Zhi , Zhao Heng , Luo Yi , Xu Min Hua , Min Xiao Li . . Journal of Kunming Medical University, 2018, 39(10): 121-125.
[5]	Zhang He Yun , Zhong Yi Ming , Li Jian , Li Hui , Zheng Ying , Xiong Jie , Wang Ying Bao , Ping Qin Rong , Yang Yang . . Journal of Kunming Medical University, 2018, 39(12): 61-64.
[6]	Hou Xiao Mei , Qi Wen Jin . Nursing Summary of Interventional Therapy in Induced Abortion after Placental Hemorrhage in Mid-term of Pregnancy. Journal of Kunming Medical University, 2017, 38(01): 142-144.
[7]	Huang Song Xia . The Effect of Evidence-based Care on the Complication Rate and Comfort in Patients with Coronary Heart Disease after Intervention Therapy. Journal of Kunming Medical University,
[8]	Lai 碁. . Journal of Kunming Medical University,
[9]	Zhang Ti Ling . . Journal of Kunming Medical University,
[10]	Wang Shi Ping . . Journal of Kunming Medical University,
[11]	Wang Shi Ping . . Journal of Kunming Medical University,
[12]	Tong Yu Yun . . Journal of Kunming Medical University,
[13]	Dai Hai Long . . Journal of Kunming Medical University,
[14]	Lu Yi Bing . . Journal of Kunming Medical University,
[15]	Liu Hai Li . . Journal of Kunming Medical University,
[16]	Wen Jiao . . Journal of Kunming Medical University,
[17]	Huang Ming . . Journal of Kunming Medical University,
[18]	Luo Jing . . Journal of Kunming Medical University,
[19]	Guo Xi . . Journal of Kunming Medical University,
[20]	Wang Qi Xian . . Journal of Kunming Medical University,