Changes in Pathogen Composition of Hand-Foot-and-Mouth Disease in Outpatient and Emergency Departments in Kunming Maternal and Child Health Hospital during 2014-2018

Xiu-fang LI; Yan WANG; Chun-ming LIU; Da-chun DAI; Gui-yun YANG

doi:10.12259/j.issn.2095-610X.S20210426

Volume 42 Issue 4

Apr. 2021

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Xiu-fang LI, Yan WANG, Chun-ming LIU, Da-chun DAI, Gui-yun YANG. Changes in Pathogen Composition of Hand-Foot-and-Mouth Disease in Outpatient and Emergency Departments in Kunming Maternal and Child Health Hospital during 2014-2018[J]. Journal of Kunming Medical University, 2021, 42(4): 138-141. doi: 10.12259/j.issn.2095-610X.S20210426

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Changes in Pathogen Composition of Hand-Foot-and-Mouth Disease in Outpatient and Emergency Departments in Kunming Maternal and Child Health Hospital during 2014-2018

doi: 10.12259/j.issn.2095-610X.S20210426

1.
Dept. of Emergency，The Maternal and Child Health Hospital of Kunming，Kunming Yunnan，650032
2.
Dept. of Outpatient，Pearl Care Clinical in Jinguang Road of Kunming
3.
Dept. of Rehabilitation Medicine，Kunming Children’s Hospital，Kunming Yunnan 650034，China

Received Date: 2020-12-16
Publish Date: 2021-04-25

Abstract

Abstract

Objective To explore the pathogenic composition of hand-foot-and-mouth disease （HFMD） in outpatient of The Maternal and Child Health Hospital of Kunming from 2014 to 2018, so as to understand the immune protection status of enterovirus 71 （EV71） vaccine, and to provide clinical basis for EV71 vaccination promotion of enterovirus. Methods Fecal samples of children diagnosed with hand-foot-and-mouth disease in outpatient and emergency department of The Maternal and Child Health Hospital of Kunming from 2014 to 2018 were collected for detection of EV71, coxsackievirus A 16 and enterovirus universal by PCR. We divided these HFMD children into observation group and control group, according to vaccination of EV71, and analysed EV71 and non-EV71 pathogens ratio of two groups. Multivariate analysis was performed with EV71 infection status, vaccination, gender and age as independent variables. Results The constituent ratio of EV71 in the observation group and the control group were 0.6% and 15%, respectively, and there were statistically significant difference （χ² = 27.088, P < 0.05）. Multi-factor analysis showed that vaccination status was influencing factor; vaccination was protective factor with protection rate of 96.8%. Conclusion Among the children with HFMD in the outpatient and emergency department of Kunming Maternal and Child Health Hospital, the infection rate of EV71 was lower in those who had been vaccinated with EV71 inactivated vaccine than those who had not.Therefore, the promotion of vaccine vaccination also had a good effect on preventing hand-foot-mouth disease caused by EV71 infection in the population.
- Hand-foot-and-mouth disease,
- Enterovirus 71,
- Etiologic,
- Pathogen composition,
- Infection rate

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References

[1]	王卫平, 毛萌, 李廷玉, 等. 儿科学[M]. 第8版, 北京: 人民卫生出版社, 2013: 3, 207.
[2]	Xing W,Liao Q,Viboud C,et a1. Hand,fool,and mouth disease in China,2008-12:An epidemiologk:al study[J]. Lancet Infect Dis,2014,14(4):308-318. doi: 10.1016/S1473-3099(13)70342-6
[3]	ZENG M,LIYF,WANG X H,et al. Epidemiology of hand,foot,and mouth disease in children in Shanghai 2007 - 2010[J]. Epidemiol Infect,2012,140(6):1122-1130. doi: 10.1017/S0950268811001622
[4]	郑亚明,常昭瑞,姜黎黎,等. 手足口病重症病例分析:基于全国手足口病监测试点数据[J]. 中华流行病学杂志,2017,38(6):759-762. doi: 10.3760/cma.j.issn.0254-6450.2017.06.014
[5]	张莹,郭磊. 中国有了全球首个手足口病疫苗[J]. 大众健康,2016,3(369):44-45.
[6]	中华人民共和国卫生部. 手足口病诊疗指南(2010版)[J]. 国际呼吸杂志,2010,30(24):1473-1475.
[7]	王国强,董建,曹静,等. 2010-2018年德州市手足口病病原学特征分析[J]. 中国实验和临床病毒学杂志,2019,33(5):485-488.
[8]	常昭瑞,张静,孙军玲,等. 中国2008-2009年手足口病报告病例流行病学特征分析[J]. 中华流行病学杂志,2011,32(7):676-680. doi: 10.3760/cma.j.issn.0254-6450.2011.07.009
[9]	Liu S L,Pan H,Liu P,et al. Comparative epidemiology and virology of fatal and nonfatal cases of hand,foot and mouth disease in mainland china from 2008 to 2014[J]. Rev Med Virol,2015,25(2):115-128. doi: 10.1002/rmv.1827
[10]	李平,庞燕,邝仕壮. 2014-2016年海口市手足口病流行特征及病原体分析[J]. 检验医学与临床,2019,16(5):610-617. doi: 10.3969/j.issn.1672-9455.2019.05.010
[11]	杨溪,姜黎黎,曹亿会,等. 2009-2019年手足口病流行特征及病原特征分析[J]. 现代预防医学,2021,48(5):789-792.
[12]	Zhao Y Y,Jin H,Zhang X F,et al. Case-fatality of hand,foot and mouth disease associated with EV71:A systematic review and Meta-analysis[J]. Epidemiol Infect,2015,143(14):3094-3102. doi: 10.1017/S095026881500028X
[13]	韦平静. 肠道病毒71型疫苗对手足口病患病率的影响[J]. 医药前沿,2018,8(8):334-335. doi: 10.3969/j.issn.2095-1752.2018.08.287
[14]	Zhu F,Xu W,Xia J,et a1. Efficacy,safety,and immunogenicity of an enterovirus 71 vaccine in China[J]. N Engl J Med,2014,370(9):818-828. doi: 10.1056/NEJMoa1304923
[15]	许文波,檀晓娟. 肠道病毒71型疫苗使用策略[J]. 中华预防医学杂志,2014,48(6):443-444. doi: 10.3760/cma.j.issn.0253-9624.2014.06.004
[16]	Li R,Liu L,Mo Z,et a1. An inactivated enterovirus 71 vaccine in healthy children[J]. N Engl J Med,2014,370(9):829-837. doi: 10.1056/NEJMoa1303224
[17]	华瑞珏,张小娟,王静,等. 2016-2017年EV71疫苗接种前后上海市静安区手足口病流行特征分析[J]. 健康必读,2019,32(8):214-215.
[18]	李文龙,刘艳艳,简千棋,等. 2011-2016年昆明市手足口病病原学特征分析[J]. 实用预防医学,2019,26(7):850-853. doi: 10.3969/j.issn.1006-3110.2019.07.021
[19]	张静. 2008-2017年中国手足口病流行趋势和病原变化动态数列分析[J]. 中华流行病学杂志,2019,40(2):147-154. doi: 10.3760/cma.j.issn.0254-6450.2019.02.005
[20]	王子江,王伶,于伟,等. 辽宁省2008-2017年手足口病流行病学特征及病原学监测分析[J]. 中华实验和临床病毒学杂志,2019,33(1):6-9. doi: 10.3760/cma.j.issn.1003-9279.2019.01.002
[21]	陈飒,赵斌,刘艳,等. 陕西省2009-2018年手足口病流行特征及动态变化分析[J]. 中华流行病学杂志,2019,40(9):1120-1124. doi: 10.3760/cma.j.issn.0254-6450.2019.09.019
[22]	陈敏玫. 手足口病病原谱和基因多态性研究进展[J]. 应用预防医学,2017,23(1):91-94. doi: 10.3969/j.issn.1673-758X.2017.01.027

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