Volume 42 Issue 4
Apr.  2021
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Xiu-fang LI, Yan WANG, Chun-ming LIU, Da-chun DAI, Gui-yun YANG. Changes in Pathogen Composition of Hand-Foot-and-Mouth Disease in Outpatient and Emergency Departments in Kunming Maternal and Child Health Hospital during 2014-2018[J]. Journal of Kunming Medical University, 2021, 42(4): 138-141. doi: 10.12259/j.issn.2095-610X.S20210426
Citation: Xiu-fang LI, Yan WANG, Chun-ming LIU, Da-chun DAI, Gui-yun YANG. Changes in Pathogen Composition of Hand-Foot-and-Mouth Disease in Outpatient and Emergency Departments in Kunming Maternal and Child Health Hospital during 2014-2018[J]. Journal of Kunming Medical University, 2021, 42(4): 138-141. doi: 10.12259/j.issn.2095-610X.S20210426

Changes in Pathogen Composition of Hand-Foot-and-Mouth Disease in Outpatient and Emergency Departments in Kunming Maternal and Child Health Hospital during 2014-2018

doi: 10.12259/j.issn.2095-610X.S20210426
  • Received Date: 2020-12-16
  • Publish Date: 2021-04-25
  •   Objective   To explore the pathogenic composition of hand-foot-and-mouth disease (HFMD) in outpatient of The Maternal and Child Health Hospital of Kunming from 2014 to 2018, so as to understand the immune protection status of enterovirus 71 (EV71) vaccine, and to provide clinical basis for EV71 vaccination promotion of enterovirus.   Methods   Fecal samples of children diagnosed with hand-foot-and-mouth disease in outpatient and emergency department of The Maternal and Child Health Hospital of Kunming from 2014 to 2018 were collected for detection of EV71, coxsackievirus A 16 and enterovirus universal by PCR. We divided these HFMD children into observation group and control group, according to vaccination of EV71, and analysed EV71 and non-EV71 pathogens ratio of two groups. Multivariate analysis was performed with EV71 infection status, vaccination, gender and age as independent variables.   Results   The constituent ratio of EV71 in the observation group and the control group were 0.6% and 15%, respectively, and there were statistically significant difference (χ2 = 27.088, P < 0.05). Multi-factor analysis showed that vaccination status was influencing factor; vaccination was protective factor with protection rate of 96.8%.   Conclusion   Among the children with HFMD in the outpatient and emergency department of Kunming Maternal and Child Health Hospital, the infection rate of EV71 was lower in those who had been vaccinated with EV71 inactivated vaccine than those who had not.Therefore, the promotion of vaccine vaccination also had a good effect on preventing hand-foot-mouth disease caused by EV71 infection in the population.
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