Antimicrobial and Antitumor Zingiberaceae Diterpene Derivatives Prepared by Structure Modification

Jie-chen QIN; Xiao-fei ZUO; Cheng ZOU; Cheng-jie TUO; Ke-tao ZHANG; Xiao-mei ZHANG; Qing ZHAO

doi:10.12259/j.issn.2095-610X.S20210501

Volume 42 Issue 5

May 2021

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Jie-chen QIN, Xiao-fei ZUO, Cheng ZOU, Cheng-jie TUO, Ke-tao ZHANG, Xiao-mei ZHANG, Qing ZHAO. Antimicrobial and Antitumor Zingiberaceae Diterpene Derivatives Prepared by Structure Modification[J]. Journal of Kunming Medical University, 2021, 42(5): 1-5. doi: 10.12259/j.issn.2095-610X.S20210501

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Antimicrobial and Antitumor Zingiberaceae Diterpene Derivatives Prepared by Structure Modification

doi: 10.12259/j.issn.2095-610X.S20210501

1.
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500
2.
Faculty of Pharmacy，Yunnan University of Chinese Medicine，Kunming Yunnan 650500，China

Received Date: 2021-02-19
Available Online: 2021-06-02
Publish Date: 2021-05-20

Abstract

Abstract

Objective Coronarin E, a diterpenoid was utilized to synthesize bioactive derivatives. Method Coronarin E underwent SeO₂ oxidation, acylation and photosensitized oxidation, two butenolide derivatives were obtained, which were subjected to antimicrobial and cytotoxic bioassays. Results Two butenolide derivatives were obtained, one showed good antimicrobial activities and the other showed good cytotoxic activities against five cancer cell lines. Conclusion It’ s worth to synthetize bioactive derivatives from Zingiberceae diterpenoids.
- Diterpene,
- Photosensitized oxidation,
- Antimicrobial activity,
- Antitumor activity

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References

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