Effects of Different Doses of Gastrodin on Conditioned Place Preference and Microglia Activation in Hippocampus of Methamphetamine Dependent Rats

Ting-na ZHU; Peng-liang LIU; Wen-juan DONG; Hao YU; Ya-mei WU; Zhao-kui HUANG; Shi-jun HONG; Yong-na ZHAO

doi:10.12259/j.issn.2095-610X.S20210502

Volume 42 Issue 5

May 2021

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Ting-na ZHU, Peng-liang LIU, Wen-juan DONG, Hao YU, Ya-mei WU, Zhao-kui HUANG, Shi-jun HONG, Yong-na ZHAO. Effects of Different Doses of Gastrodin on Conditioned Place Preference and Microglia Activation in Hippocampus of Methamphetamine Dependent Rats[J]. Journal of Kunming Medical University, 2021, 42(5): 6-11. doi: 10.12259/j.issn.2095-610X.S20210502

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Effects of Different Doses of Gastrodin on Conditioned Place Preference and Microglia Activation in Hippocampus of Methamphetamine Dependent Rats

doi: 10.12259/j.issn.2095-610X.S20210502

1.
School of Pharmacy and Key Laboratory of Natural Medicine Pharmacology of Yunnan Province
2.
School of Forensic Medicine
3.
School of International Education，Kunming Medical University， Kunming Yunnan 650500，China

Received Date: 2021-01-14
Available Online: 2021-06-03
Publish Date: 2021-05-20

Abstract

Abstract

Objective To study the effects of different dosages of gastrodin on conditioned place preference and hippocampal microglia activation in methamphetamine （Meth）-dependent rats. Methods Meth dependent CPP model was established by intraperitoneal injection of meth （10 mg/kg, QD, 14 d） and then gastrodin （10 mg/kg, 30 mg/kg, 100 mg/kg） was used for 14 d to determine the effect of gastrodin on CPP in meth dependent rats. After that, the immunofluorescence technique was used to detect the effect of different doses of gastrodin on the activation of microglia in hippocampus. Results The Meth-dependent rat CPP model was successfully established. Gastrodin treatment could shorten the time of the rats stayed in the drug-paired chamber. Compared with the saline group, the CPP effect of the Meth group was significantly enhanced, and the difference was statistically significant （P < 0.05）. Compared with Meth group, 10 mg/kg, 30 mg/kg, and 100 mg/kg gastrodin treated groups showed a dose-dependent reduction of Meth-induced CPP effect, and 100 mg/kg of gastrodin could basically eliminate the CPP effect induced by Meth. The results of immunofluorescence showed that, compared with the normal saline group, the hippocampal microglia of the Meth group was significantly activated. After the treatment with 10 mg/kg, 30 mg/kg, or 100 mg/kg gastrodin, the microglia cell activation was inhibited by gastrodin, and the performance was more obvious after the treatment with 30 mg/kg and 100 mg/kg gastrodin. Conclusion Gastrodin can reduce the CPP effect of Meth-dependent rat in a dose-dependent manner; gastrodin has a potential effect on methamphetamine dependence. Gastrodin can inhibit the activation of hippocampal microglia in hippocampus region of Meth-dependent rat.
- Methamphetamine （Meth）,
- Gastrodin,
- Conditional position preference （CPP）,
- Hippocampus,
- Microglia

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References(14)

References

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