The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma

Shao-hua YANG; Zhou-Jun LIAO; Sheng HU; Mao-lin HONG; Zhi-Mei SONG; Qun WEI; Xiao-wen ZHANG

doi:10.12259/j.issn.2095-610X.S20210505

Volume 42 Issue 5

May 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(5): 24-28

Shao-hua YANG, Zhou-Jun LIAO, Sheng HU, Mao-lin HONG, Zhi-Mei SONG, Qun WEI, Xiao-wen ZHANG. The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2021, 42(5): 24-28. doi: 10.12259/j.issn.2095-610X.S20210505

Citation:

Shao-hua YANG, Zhou-Jun LIAO, Sheng HU, Mao-lin HONG, Zhi-Mei SONG, Qun WEI, Xiao-wen ZHANG. The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2021, 42(5): 24-28. doi: 10.12259/j.issn.2095-610X.S20210505

Citation:

Shao-hua YANG, Zhou-Jun LIAO, Sheng HU, Mao-lin HONG, Zhi-Mei SONG, Qun WEI, Xiao-wen ZHANG. The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2021, 42(5): 24-28. doi: 10.12259/j.issn.2095-610X.S20210505

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The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma

doi: 10.12259/j.issn.2095-610X.S20210505

1.
Dept. of Hepatobiliary and Pancreatic Surgery
2.
Dept. of Pathology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2021-01-04
Available Online: 2021-06-02
Publish Date: 2021-05-20

Abstract

Abstract

Objective To study the expression of eukaryotic translation initiation factor 5A2 （eIF5A2） in intrahepatic cholangiocarcinoma and its correlation with nerve invasion and peripheral adipose tissue infiltration. Methods Paraffin sections from 156 patients with intrahepatic cholangiocarcinoma were collected from October 2013 to October 2020 in the Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital of Kunming Medical University, and the normal liver tissues from 30 cases of hepatic hemangioma undergoing partial hepatectomy were collected during the same period. In the control group, the immunohistochemical methods were used to detect the expression level of eIF5A2, and pathological data were collected to analyze the correlation between eIF5A2 and nerve invasion and peripheral adipose tissue infiltration. Results In 156 cases of intrahepatic cholangiocarcinoma tissue sections, 95 cases （60.9%） had high expression of eIF5A2. The high expression rate of eIF5A2 in normal liver tissue bile duct epithelium was 13.3%. The expression of eIF5A2 was significantly related to nerve invasion and peripheral adipose tissue infiltration （P < 0.05）. Conclusion eIF5A2 is highly expressed in intrahepatic cholangiocarcinoma and is significantly related to nerve invasion and surrounding adipose tissue infiltration.
- Intrahepatic cholangiocarcinoma,
- Eukaryotic translation initiation factor-5A2,
- Immunohistochemical staining

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References(27)

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