A Comparative Study of Fecal Bacteria between Patients with Malignant Obstructive Jaundice and Healthy People

Yan-bo SUN; Wei-ming LI; Shu-min LI; Yue-ying LIN; Yun-yun CEN; Peng-yuan XU

doi:10.12259/j.issn.2095-610X.S20210516

Volume 42 Issue 5

May 2021

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Yan-bo SUN, Wei-ming LI, Shu-min LI, Yue-ying LIN, Yun-yun CEN, Peng-yuan XU. A Comparative Study of Fecal Bacteria between Patients with Malignant Obstructive Jaundice and Healthy People[J]. Journal of Kunming Medical University, 2021, 42(5): 87-91. doi: 10.12259/j.issn.2095-610X.S20210516

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A Comparative Study of Fecal Bacteria between Patients with Malignant Obstructive Jaundice and Healthy People

doi: 10.12259/j.issn.2095-610X.S20210516

Yan-bo SUN^{1, 2},
Wei-ming LI^{1, 2},
Shu-min LI^{1, 2},
Yue-ying LIN^{1, 2},
Yun-yun CEN^{1, 2
,
,},
Peng-yuan XU^{1, 2}

1.
Dept. of Gastrointestinal Surgery，The 2nd Affiliated Hospital of Kunming Medical University. Kunming Yunnan 650101
2.
Research Center for Surgical Clinical Nutrition of Yunnan Province，Kunming Yunnan 650101，China

Received Date: 2021-01-08
Available Online: 2021-06-03
Publish Date: 2021-05-20

Abstract

Abstract

Objective To explore the changing characteristics of fecal bacteria in patients with malignant obstructive jaundice. Methods From January 2019 to May 2019, 87 cases with malignant obstructive jaundice were taken as case bank and screened by inclusion and exclusion criteria. After that, 10 patients and 10 healthy relatives of patients were selected, age, sex and BMI were recorded, and faeces were sent for 16srDNA copy number. Results （1）The fecal bacteria abundance and diversity index of the experimental group were lower than that of the control group, but there was no statistical significance （P < 0.05）. However, when the data of fecal bacteria abundance were presented in the Heatmap, the intuitive difference was more obvious. （2） The data of the two groups were subdivided by bacteria genus, and it was found that the composition of fecal bacteria genus in the experimental group changed fundamentally compared with that in the control group （P < 0.05）. Among them, Escherichia-Shigella, Streptococcus, Veillonella, Enterococcus, Akkermansia increased significantly, while the bacteria genera of wiesia and clostridium declined significantly. Whether the intestinal flora can be rebalanced may affect the therapeutic effect. Conclusion The fecal flora structure of patients with malignant obstructive jaundice is significantly different from that of normal control group, and the dominant flora genus has been fundamentally changed.
- Malignant obstructive jaundice,
- Fecal bacteria,
- Balance

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