Abnormal Coagulation Parameters in Patients with Early Colorectal Cancer and Its Clinical Significance

Zi-hong CHEN; Shi-bo SUN; Xian-mei WANG; Shan-shan YU; Xiu-fang WU; Xiang-shan CHEN; Ting GENG; Hong LIU; Xian-min LIU; Qiong NAN

doi:10.12259/j.issn.2095-610X.S20210518

Volume 42 Issue 5

May 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(5): 96-100

Zi-hong CHEN, Shi-bo SUN, Xian-mei WANG, Shan-shan YU, Xiu-fang WU, Xiang-shan CHEN, Ting GENG, Hong LIU, Xian-min LIU, Qiong NAN. Abnormal Coagulation Parameters in Patients with Early Colorectal Cancer and Its Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(5): 96-100. doi: 10.12259/j.issn.2095-610X.S20210518

Citation:

Zi-hong CHEN, Shi-bo SUN, Xian-mei WANG, Shan-shan YU, Xiu-fang WU, Xiang-shan CHEN, Ting GENG, Hong LIU, Xian-min LIU, Qiong NAN. Abnormal Coagulation Parameters in Patients with Early Colorectal Cancer and Its Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(5): 96-100. doi: 10.12259/j.issn.2095-610X.S20210518

Citation:

Zi-hong CHEN, Shi-bo SUN, Xian-mei WANG, Shan-shan YU, Xiu-fang WU, Xiang-shan CHEN, Ting GENG, Hong LIU, Xian-min LIU, Qiong NAN. Abnormal Coagulation Parameters in Patients with Early Colorectal Cancer and Its Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(5): 96-100. doi: 10.12259/j.issn.2095-610X.S20210518

PDF( 598 KB)

Abnormal Coagulation Parameters in Patients with Early Colorectal Cancer and Its Clinical Significance

doi: 10.12259/j.issn.2095-610X.S20210518

1.
Dept. of Gastroenterology
2.
Dept. of Pulmonary and Critical Care Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
3.
Dept. of Basic Medicine，Kunming Medical University，Kunming Yunnan 650500
4.
Dept. of General Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-02-05
Available Online: 2021-06-03
Publish Date: 2021-05-20

Abstract

Abstract

Objective Our aim was to investigate the expression and significance of coagulation markers in patients with early colorectal cancer. Methods This study was conducted by the case-control study to collect data from patients with early colorectal cancer confirmed by pathological examination at the First Affiliated Hospital of Kunming Medical University from January 1, 2010 to December 31, 2018, and the difference of coagulation-related indexes was compared between the early cancer group and the control group. Results Compared with the control group, PT, PTR, FIB, TT, APTT, PLT, MPV in the early cancer group were lower than those in the control group, and the values of PT, PTR, TT, APTT, MPV were higher than those in the control group （P < 0.05）, showing that FIB and MPV were independent risk factors for early colorectal cancer. Conclusion Abnormalities in the coagulation system are also present in patients with early colorectal cancer. It seems that patients with early colorectal cancer need prophylactic antiplatelet and anticoagulant therapy, but the time of anti-platelet therapy and anti-coagulant therapy, as well as the types and methods of medication, need to be further studied.
- Early colorectal cancer,
- Colorectal cancer,
- Coagulation index

FullText(HTML)

References(25)

References

[1]	Bray F,Ferlay J,Soerjomataram I,et al. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2018,68(6):394-424. doi: 10.3322/caac.21492
[2]	Arnold M,Sierra M S,Laversanne M,et al. Global patterns and trends in colorectal cancer incidence and mortality[J]. Gut,2017,66(4):683-691. doi: 10.1136/gutjnl-2015-310912
[3]	Shin J W,Han K S,Hyun J H,et al. Risk of recurrence after endoscopic resection of early colorectal cancer with positive margins[J]. Endoscopy,2018,50(3):241-247. doi: 10.1055/s-0043-120441
[4]	Komurcuoglu B,Ulusoy S,Gayaf M,et al. Prognostic value of plasma D-dimer levels in lung carcinoma[J]. Tumori,2011,97(6):743-748. doi: 10.1177/030089161109700611
[5]	Ohta H,Miyake T,Shimizu T,et al. The impact of pharmacological thromboprophylaxis and disease-stage on postoperative bleeding following colorectal cancer surgery[J]. World J Surg Oncol,2019,17(1):110. doi: 10.1186/s12957-019-1653-1
[6]	Lee S, Huh S J, Oh S Y, et al. Clinical significance of coagulation factors in operable colorectal cancer[J]. Oncol Lett,2017,13(6):4669-4674.
[7]	Kawai K,Watanabe T. Colorectal cancer and hypercoagulability[J]. Surg Today,2014,44(5):797-803. doi: 10.1007/s00595-013-0606-5
[8]	Kobayashi T,Nakamura M,Sakuma M,et al. Incidence of pulmonary thromboembolism (PTE) and new guidelines for PTE prophylaxis in Japan[J]. Clin Hemorheol Microcirc,2006,35(1-2):257-259.
[9]	Pasche B. Aspirin-from prevention to targeted therapy[J]. N Engl J Med,2012,367(17):1650-1651. doi: 10.1056/NEJMe1210322
[10]	National Clinical Research Center for Digestive Diseases (Shanghai),National Early Gastrointestinal-Cancer Prevention & Treatment Center Alliance (GECA),Chinese Society of Digestive Endoscopy,et al. Chinese consensus of early colorectal cancer screening(2019,Shanghai)[J]. Zhonghua Nei Ke Za Zhi,2019,58(10):736-744.
[11]	Wojtukiewicz M Z,Mysliwiec M,Sierko E,et al. Elevated microparticles,thrombin-antithrombin and VEGF levels in colorectal cancer patients undergoing chemotherapy[J]. Pathol Oncol Res,2020,26(4):2499-2507. doi: 10.1007/s12253-020-00854-8
[12]	Kuderer N M,Ortel T L,Francis C W. Impact of venous thromboembolism and anticoagulation on cancer and cancer survival[J]. J Clin Oncol,2009,27(29):4902-4911. doi: 10.1200/JCO.2009.22.4584
[13]	Chaturvedi S,Sidana S,Elson P,et al. Symptomatic and incidental venous thromboembolic disease are both associated with mortality in patients with prostate cancer[J]. PLoS One,2014,9(8):e94048. doi: 10.1371/journal.pone.0094048
[14]	Khorana A A,Francis C W,Culakova E,et al. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy[J]. J Thromb Haemost,2007,5(3):632-634. doi: 10.1111/j.1538-7836.2007.02374.x
[15]	吴玥,田柳,周本宏. 430例住院肿瘤患者抗凝预防回顾性分析[J]. 医药导报,2020,39(1):101-104.
[16]	Elmoamly S,Mattar M,Yacoub M F,et al. Can biomarkers of coagulation,platelet activation,and inflammation predict venous thromboembolism in patients with haematological malignancies?[J]. Acta Haematol,2019,141(4):245-253. doi: 10.1159/000496914
[17]	Heit J A,Silverstein M D,Mohr D N,et al. Risk factors for deep vein thrombosis and pulmonary embolism:A population-based case-control study[J]. Arch Intern Med,2000,160(6):809-815. doi: 10.1001/archinte.160.6.809
[18]	Kearon C,Akl EA,Ornelas J,et al. Antithrombotic therapy for VTE disease:Chest guideline and expert panel report[J]. Chest,2016,149(2):315-352. doi: 10.1016/j.chest.2015.11.026
[19]	丁轶. 脑血管金属支架植入脑动脉血管血栓形成的风险评估[J]. 血栓与止血学,2020,26(5):789-791. doi: 10.3969/j.issn.1009-6213.2020.05.025
[20]	谢惠明,何春柳. 冠心病患者应用阿司匹林与波立维治疗后出凝血功能研究分析[J]. 海峡药学,2020,32(4):170-172. doi: 10.3969/j.issn.1006-3765.2020.04.069
[21]	Tang J Q, Fan Q, Wu W H, et al. Extrahepatic synthesis of coagulation factor VII by colorectal cancer cells promotes tumor invasion and metastasis[J]. Chin Med J (Engl),2010,123(24):3559-3565.
[22]	Kwaan H C,Lindholm P F. Fibrin and fibrinolysis in cancer[J]. Semin Thromb Hemost,2019,45(4):413-422. doi: 10.1055/s-0039-1688495
[23]	Folkman J. Tumor angiogenesis:Therapeutic implications[J]. N Engl J Med,1971,285(21):1182-1186. doi: 10.1056/NEJM197111182852108
[24]	Sasaki K,Kawai K,Tsuno N H,et al. Impact of preoperative thrombocytosis on the survival of patients with primary colorectal cancer[J]. World J Surg,2012,36(1):192-200. doi: 10.1007/s00268-011-1329-7
[25]	Yamashita H,Kitayama J,Taguri M,et al. Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response[J]. World J Surg,2009,33(6):1298-305. doi: 10.1007/s00268-009-9992-7

Relative Articles(20)

Relative Articles

[1]	Bo LIU, Qiaolian WU, Quanchang ZHANG. The Effects of the Laparoscopic and Open Surgery on the Postoperative Intestinal Function Recovery Time in Elderly Patients with Colorectal Cancer. Journal of Kunming Medical University, 2024, 45(1): 143-148. doi: 10.12259/j.issn.2095-610X.S20240124
[2]	Zhaoyang CAO, Sijia LIU, Yaying YANG. Advancements of Radiomics in Coloractal Cancer. Journal of Kunming Medical University, 2024, 44(1B): 1-7.
[3]	Yuan WANG, Rong LI, Jiaojiao CHEN, Yanli SHEN, Fengdi HU. Clinical Value of Fecal SDC2 Gene Methylation Detection in Early Screening of Colorectal Cancer. Journal of Kunming Medical University, 2023, 44(5): 138-143. doi: 10.12259/j.issn.2095-610X.S20230524
[4]	Haimei GOU, Li FANG, Xiaowu ZHONG. Relationship between Mutations of KRAS，NRAS and BRAF Genes and Colorectal Liver Metastases. Journal of Kunming Medical University, 2023, 44(1): 19-24. doi: 10.12259/j.issn.2095-610X.S20230106
[5]	Liju ZHANG, Xiaoming JIANG, Changxian CHEN, Xi WU, Zhenyong ZHANG, Weijun LIU. Long Non-coding RNA-p21 Regulates the MicroRNA-9 / Sirtuin-1 Signaling Pathway to Reverse Oxaliplatin Resistance in Colorectal Cancer Cells. Journal of Kunming Medical University, 2022, 43(5): 27-32. doi: 10.12259/j.issn.2095-610X.S20220519
[6]	Helong CHE, Zhijin LI, Keqiang WANG, Weiming QIU, Yi CAO, Laibin LUO. Effect Analysis of Emergency Endoscopic Treatment for Anastomotic Hemorrhage after Colorectal Cancer Resection. Journal of Kunming Medical University, 2022, 43(10): 122-126. doi: 10.12259/j.issn.2095-610X.S20221032
[7]	Yubin LE, Shikui GUO. The Value of Serum Adipokine in the Long-term Prognosis of Colorectal Cancer Patients. Journal of Kunming Medical University, 2022, 43(4): 82-88. doi: 10.12259/j.issn.2095-610X.S20220417
[8]	Yan-fen MA, Jian HU, Ning ZHANG, Qian WU, Xiao-qin WANG. Changes and Abnormal Patterns of Coagulation Indicators in Patients with Lung Adenocarcinoma and Tuberculosis Pleural Effusion. Journal of Kunming Medical University, 2021, 42(10): 145-150. doi: 10.12259/j.issn.2095-610X.S20211021
[9]	Jing-hua LIU, Wei CHANG, Fu-bing YU, Juan SHENG, FENG Cheng-cheng, Ni-shan ZHAO. The Expression of C/EBPδ in Colorectal Cancer and Its Effect on the Proliferation of Cancer Cells. Journal of Kunming Medical University, 2021, 42(9): 57-64. doi: 10.12259/j.issn.2095-610X.S20210913
[10]	Yang Hong Jun , Wang Xiao Bin , Sun Xiang Hua , Li Zhi Gang . . Journal of Kunming Medical University, 2020, 41(06): 105-108.
[11]	Deng Lan Ying , Peng Pai Lan , Liu Yan Ni . . Journal of Kunming Medical University, 2020, 41(09): 125-131.
[12]	Yang Jing Yu , Li Wen Liang . . Journal of Kunming Medical University, 2020, 41(04): 150-156.
[13]	Zou Si Si , Song Xiao Yan , Deng Fei , Xu Ji Zong . . Journal of Kunming Medical University, 2019, 40(11): 92-96.
[14]	Zhao Min , Zhang Qiang , Ma Yong Ci , Long Fei , Lin Yan Ping , Xu Xue Bin , Zhang Jin Ping . A Clinical Features Analysis of 1 000 Cases of Colorectal Cancer in Yunnan Tumor Hospital. Journal of Kunming Medical University, 2018, 39(05): 90-93.
[15]	Wang Ruo Tian . . Journal of Kunming Medical University,
[16]	Zhong Lin . . Journal of Kunming Medical University,
[17]	Yang Jian Hua . . Journal of Kunming Medical University,
[18]	Xiao Yun . . Journal of Kunming Medical University,
[19]	. A Clinical Analysis of Surgical Treatment for 56 Elderly Patients with Colorectal Cancer. Journal of Kunming Medical University,
[20]	Yang Yi Ming . Clinical Experiences in Diagnosis and Treatment of Intestinal Obstruction of 48 Patients with Colorectal Cancer. Journal of Kunming Medical University,