Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children

Ting-ting MAO; Gui-fen LI; Hua-ping CAO; Huang WU

doi:10.12259/j.issn.2095-610X.S20210523

Volume 42 Issue 5

May 2021

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Ting-ting MAO, Gui-fen LI, Hua-ping CAO, Huang WU. Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children[J]. Journal of Kunming Medical University, 2021, 42(5): 126-130. doi: 10.12259/j.issn.2095-610X.S20210523

Citation:

Ting-ting MAO, Gui-fen LI, Hua-ping CAO, Huang WU. Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children[J]. Journal of Kunming Medical University, 2021, 42(5): 126-130. doi: 10.12259/j.issn.2095-610X.S20210523

Citation:

Ting-ting MAO, Gui-fen LI, Hua-ping CAO, Huang WU. Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children[J]. Journal of Kunming Medical University, 2021, 42(5): 126-130. doi: 10.12259/j.issn.2095-610X.S20210523

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Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children

doi: 10.12259/j.issn.2095-610X.S20210523

1.
Dept. of Pediatric Internal Medicine，The Third People’s Hospital of Yichang City，Yichang Hubei 443000
2.
Dept. of Bone Surgery，The Second People’s Hospital of Three Gorges University（Yichang Municipal Second People’s Hospital），Yichang Hubei 443000，China

Received Date: 2021-02-16
Publish Date: 2021-05-25

Abstract

Abstract

Objective To investigate the effect of different doses of Solina xin combined with Xingpi Yanger granule on primary nocturnal enuresis （PNE） in children. Methods From March 2018 to January 2020, 120 PNE children admitted to Pediatric Internal Medical Department in The Third People’ s Hospital of Hubei province Yichang city were selected as the study subjects. The patients were divided into Group A （40 cases, low-dose Solina Xinlianxingpi Yanger granule）, group B （40 cases, medium-dose Solina Xinlianxingpi Yanger granule）, and group C （40 cases, high-dose Solina Xinlianxingpi Yanger granule） by using the random number table method. The clinical efficacy of the three groups was compared. Bladder volume and bladder volume wall thickness index （BVWI） before and after the treatment were compared among the 3 groups. The relapses of the 3 groups were compared. The occurrence of adverse reactions during the treatment was compared among the 3 groups. Results There was no significant difference in the total effective rate among the 3 groups （P > 0.05）. There were no statistically significant differences in bladder volume and BVWI among the 3 groups before the treatment （ P > 0.05）. Bladder volume was significantly increased after the treatment compared with that before the treatment in the 3 groups （ P < 0.05）, and BVWI was significantly decreased after the treatment compared with that before the treatment （ P < 0.05）. There were no statistically significant differences in bladder volume and BVWI among the 3 groups after the treatment （ P > 0.05）. There was no statistically significant difference in the recurrence rate after 3 months and 6 months of treatment among the 3 groups （ P > 0.05）. The incidence of adverse reactions in group C was higher than that in group A and group B （ P < 0.05）, and the incidence of adverse reactions in group B was higher than that in group A （ P > 0.05）. Conclusion Low, medium and high doses of Solinaxin combined with Xingpi Yanger Granule have similar effects on the treatment of PNE in children, both of which can improve the bladder function of children, and have little influence on the recurrence rate. However, high dose solinazine can significantly increase the occurrence of adverse reactions, so it is recommended to select low dose solinazine clinically for safety reasons.
- Solifenacin,
- Xingpi Yanger Granule,
- Children,
- Primary nocturnal enuresis,
- Effect

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References(14)

References

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