Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children

Ting-ting MAO; Gui-fen LI; Hua-ping CAO; Huang WU

doi:10.12259/j.issn.2095-610X.S20210523

Volume 42 Issue 5

May 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(5): 126-130

Ting-ting MAO, Gui-fen LI, Hua-ping CAO, Huang WU. Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children[J]. Journal of Kunming Medical University, 2021, 42(5): 126-130. doi: 10.12259/j.issn.2095-610X.S20210523

Citation:

Ting-ting MAO, Gui-fen LI, Hua-ping CAO, Huang WU. Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children[J]. Journal of Kunming Medical University, 2021, 42(5): 126-130. doi: 10.12259/j.issn.2095-610X.S20210523

Citation:

Ting-ting MAO, Gui-fen LI, Hua-ping CAO, Huang WU. Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children[J]. Journal of Kunming Medical University, 2021, 42(5): 126-130. doi: 10.12259/j.issn.2095-610X.S20210523

PDF( 606 KB)

Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children

doi: 10.12259/j.issn.2095-610X.S20210523

1.
Dept. of Pediatric Internal Medicine，The Third People’s Hospital of Yichang City，Yichang Hubei 443000
2.
Dept. of Bone Surgery，The Second People’s Hospital of Three Gorges University（Yichang Municipal Second People’s Hospital），Yichang Hubei 443000，China

Received Date: 2021-02-16
Publish Date: 2021-05-25

Abstract

Abstract

Objective To investigate the effect of different doses of Solina xin combined with Xingpi Yanger granule on primary nocturnal enuresis （PNE） in children. Methods From March 2018 to January 2020, 120 PNE children admitted to Pediatric Internal Medical Department in The Third People’ s Hospital of Hubei province Yichang city were selected as the study subjects. The patients were divided into Group A （40 cases, low-dose Solina Xinlianxingpi Yanger granule）, group B （40 cases, medium-dose Solina Xinlianxingpi Yanger granule）, and group C （40 cases, high-dose Solina Xinlianxingpi Yanger granule） by using the random number table method. The clinical efficacy of the three groups was compared. Bladder volume and bladder volume wall thickness index （BVWI） before and after the treatment were compared among the 3 groups. The relapses of the 3 groups were compared. The occurrence of adverse reactions during the treatment was compared among the 3 groups. Results There was no significant difference in the total effective rate among the 3 groups （P > 0.05）. There were no statistically significant differences in bladder volume and BVWI among the 3 groups before the treatment （ P > 0.05）. Bladder volume was significantly increased after the treatment compared with that before the treatment in the 3 groups （ P < 0.05）, and BVWI was significantly decreased after the treatment compared with that before the treatment （ P < 0.05）. There were no statistically significant differences in bladder volume and BVWI among the 3 groups after the treatment （ P > 0.05）. There was no statistically significant difference in the recurrence rate after 3 months and 6 months of treatment among the 3 groups （ P > 0.05）. The incidence of adverse reactions in group C was higher than that in group A and group B （ P < 0.05）, and the incidence of adverse reactions in group B was higher than that in group A （ P > 0.05）. Conclusion Low, medium and high doses of Solinaxin combined with Xingpi Yanger Granule have similar effects on the treatment of PNE in children, both of which can improve the bladder function of children, and have little influence on the recurrence rate. However, high dose solinazine can significantly increase the occurrence of adverse reactions, so it is recommended to select low dose solinazine clinically for safety reasons.
- Solifenacin,
- Xingpi Yanger Granule,
- Children,
- Primary nocturnal enuresis,
- Effect

FullText(HTML)

References(14)

References

[1]	Kosilov K V,Geltser B I,Loparev S A,et al. The optimal duration of alarm therapy use in children with primary monosymptomatic nocturnal enuresis[J]. Journal of Pediatric Urology,2018,14(5):447-447.
[2]	余益萍,田永波,刘颖,等. 醒脾养儿颗粒治疗小儿原发性夜间遗尿症的临床观察[J]. 中国药房,2017,28(6):738-741. doi: 10.6039/j.issn.1001-0408.2017.06.05
[3]	黎灿强,邱敏捷,徐乐. 应用小剂量索利那新治疗小儿遗尿症的体会[J]. 天津医药,2015,43(4):436-438. doi: 10.11958/j.issn.0253-9896.2015.04.028
[4]	ZHANG Ling-xian. Clinical value of small dose of solifenacin new treatment for children with primary nocturnal enuresis[J]. Journal of Henan Medical College,2016,13(4):123-126.
[5]	许传亮,宋奇翔,方祖军,等. 儿童夜间遗尿症诊治指南[J]. 中华泌尿外科杂志,2015,36(11):801-805. doi: 10.3760/cma.j.issn.1000-6702.2015.11.001
[6]	Chang S J,Laecke E V,Bauer S B,et al. Treatment of daytime urinary incontinence:A standardization document from the International Children’ s Continence Society[J]. Neurourology & Urodynamics,2017,36(1):7-14.
[7]	黄小亮,郭玉红,李蔚,等. 改良清洁间歇导尿护理方法对预防尿路感染的疗效观察[J]. 河北医药,2019,41(20):3181-3184. doi: 10.3969/j.issn.1002-7386.2019.20.034
[8]	丁丽凤,马骏,金莹莹. 推拿联合行为干预治疗儿童原发性夜间遗尿症临床观察[J]. 上海中医药大学学报,2019,33(1):52-55.
[9]	Jianguo W,Qingsong P. Advances in etiology and treatment of refractory nocturnal enuresis in adolescents[J]. Journal of Dali University,2019,12(10):142-145.
[10]	王冠群,刘毅东,孙杰,等. 坦索罗辛与索利那新在轻、中度良性前列腺增生合并膀胱过度活动症患者中的应用效果[J]. 检验医学与临床,2018,15(9):45-48.
[11]	孔令军,赵佳龙. 索利那新对膀胱过度活动症病人逼尿肌功能及预后的影响[J]. 临床外科杂志,2019,27(9):798-800. doi: 10.3969/j.issn.1005-6483.2019.09.025
[12]	尹文利,王娟,李双辉,等. 康复新液联合索利那新治疗前列腺电切术后膀胱痉挛的疗效观察[J]. 现代药物与临床,2018,33(6):1448-1452.
[13]	尹文利,李双辉,李永禄. 坦索罗辛联用索利那新与联用托特罗定治疗前列腺电切术后膀胱痉挛效果比较[J]. 现代仪器与医疗,2018,24(5):121-123.
[14]	沈小钰,郭竹英,金莹莹,等. 基于小儿遗尿症临床症候群选用缩泉胶囊和醒脾养儿颗粒的疗效观察[J]. 中华全科医学,2019,17(2):173-175.

Relative Articles(20)

Relative Articles

[1]	Lan SHEN, Chaoming CHEN, Jianneng DAI, Lunqing PU, Tianrui WANG, Gang MA. The Application Effect and Influencing Factors of Rapid Rehabilitation Techniques Combined with Damage Control Surgical Techniques in Patients with Multiple Injuries. Journal of Kunming Medical University, 2024, 45(5): 103-108. doi: 10.12259/j.issn.2095-610X.S20240516
[2]	Yike TANG, Rencai LU, Yunhai JI, Bo SHE, Yanping QING. Effect of Reasonable Sedation on Image Quality before PET/CT Examination in Children with Epilepsy. Journal of Kunming Medical University, 2022, 43(11): 178-184. doi: 10.12259/j.issn.2095-610X.S20221124
[3]	Hao YANG, Guo-yun ZHANG, De-cai WANG, Yun-rui GUO, Ye-cai ZHANG, Jian-ming YANG. The Effect of Femoral Nerve Block and Oral Analgesia Guided by B-ultrasound on Preoperative Analgesia of Middle and Upper Femoral Fractures in Elderly Patients. Journal of Kunming Medical University, 2021, 42(9): 138-143. doi: 10.12259/j.issn.2095-610X.S20210931
[4]	Luo Yang . Curative Effect of Tanreqing Injection Combined with Ganciclovir in the Treatment of Pediatric Respiratory Syncytial Virus Pneumonia. Journal of Kunming Medical University,
[5]	Zhu Tian Bo . Clinical Application of Preoperative New Adjuvant Chemotherapy in Treatment of Cervical Cancer. Journal of Kunming Medical University,
[6]	Chen Zong 劼. . Journal of Kunming Medical University,
[7]	Cheng Zhong . . Journal of Kunming Medical University,
[8]	Sun Xuan . . Journal of Kunming Medical University,
[9]	Yang Ling . . Journal of Kunming Medical University,
[10]	Xiong Ping . . Journal of Kunming Medical University,
[11]	Zhu Li Xian . . Journal of Kunming Medical University,
[12]	Wang Xiao Yan . . Journal of Kunming Medical University,
[13]	Min Jie Qing . . Journal of Kunming Medical University,
[14]	Deng Dan Qi . . Journal of Kunming Medical University,
[15]	Zhang Xiu Qiong . . Journal of Kunming Medical University,
[16]	Xiang Zheng . . Journal of Kunming Medical University,
[17]	Duo Lin . . Journal of Kunming Medical University,
[18]	Liu Chun Li . . Journal of Kunming Medical University,
[19]	Li Jun Ming . Correlation between the Stage of Rectal Adenocarcinoma and the Cell Immune Status. Journal of Kunming Medical University,
[20]	Li Liu Zheng . . Journal of Kunming Medical University,