The Association of Methylenetetrahydrofolate Reductase Gene Polymorphism with Coronary Heart Disease

Liu LI; Xiao-chan ZHANG; Qi RU; Shuo WANG; Quo-qing QI; Hong-liang ZHAO

doi:10.12259/j.issn.2095-610X.S20210525

Volume 42 Issue 5

May 2021

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Liu LI, Xiao-chan ZHANG, Qi RU, Shuo WANG, Quo-qing QI, Hong-liang ZHAO. The Association of Methylenetetrahydrofolate Reductase Gene Polymorphism with Coronary Heart Disease[J]. Journal of Kunming Medical University, 2021, 42(5): 138-142. doi: 10.12259/j.issn.2095-610X.S20210525

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The Association of Methylenetetrahydrofolate Reductase Gene Polymorphism with Coronary Heart Disease

doi: 10.12259/j.issn.2095-610X.S20210525

1.
Dept. of Cardiology，Hebei Medical University First Hospital，Shijiazhuang Hebei 050031
2.
Dept. of Cardiology，Shijiazhuang First Hospital，Shijiazhuang Hebei 050011，China

Received Date: 2021-02-20
Available Online: 2021-06-08
Publish Date: 2021-05-20

Abstract

Abstract

Objective To analyze the relationship between methylenetetrahydrofolate reductase （MTHFR） gene polymorphism and severity of coronary heart disease. Methods A total of 400 patients who were to undergo coronary angiography and stent implantation when necessary were tested with folate metabolism 677 gene. And according to MTHFR C677T polymorphism, these patients were divided into three groups: C / C, C / T, T / T and Gensini score of coronary artery was used to evaluate the mace events （including cardiac death, myocardial infarction, heart failure, readmission for cardiac reasons and target vessel revascularization） within 180 days after PCI. Results （1） Patients with MTHFR C677T T/T genotype had significantly higher Gensini scores than those with C/T and C/C genotypes （P < 0.05）. （2） Patients with MTHFR C677T T/T genotype had significantly higher mace events than those with C/T and C/C genotypes after 180 days of PCI （P < 0.05）. Conclusion （1） There is a significant correlation between MTHFR gene polymorphism and severity of coronary heart disease; （2） There is a significant correlation between MTHFR gene polymorphism and the mace events after 180 days of PCI.
- MTHFR,
- Gensini score,
- PCI,
- MACE

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References(13)

References

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