The Interaction among Gene Polymorphisms of RANTES and Its Receptor CCR5 and Environmental Factors in the Development of T2DM in Kunming Han Nationality

Jie CHEN; Wei-chang GUO; He-jia YIN; Hong-xia YAN; Fan ZHANG; Yao-yi WANG; Hui-fang LI

doi:10.12259/j.issn.2095-610X.S20210606

Volume 42 Issue 6

Jul. 2021

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Jie CHEN, Wei-chang GUO, He-jia YIN, Hong-xia YAN, Fan ZHANG, Yao-yi WANG, Hui-fang LI. The Interaction among Gene Polymorphisms of RANTES and Its Receptor CCR5 and Environmental Factors in the Development of T2DM in Kunming Han Nationality[J]. Journal of Kunming Medical University, 2021, 42(6): 38-44. doi: 10.12259/j.issn.2095-610X.S20210606

Citation:

Jie CHEN, Wei-chang GUO, He-jia YIN, Hong-xia YAN, Fan ZHANG, Yao-yi WANG, Hui-fang LI. The Interaction among Gene Polymorphisms of RANTES and Its Receptor CCR5 and Environmental Factors in the Development of T2DM in Kunming Han Nationality[J]. Journal of Kunming Medical University, 2021, 42(6): 38-44. doi: 10.12259/j.issn.2095-610X.S20210606

Citation:

Jie CHEN, Wei-chang GUO, He-jia YIN, Hong-xia YAN, Fan ZHANG, Yao-yi WANG, Hui-fang LI. The Interaction among Gene Polymorphisms of RANTES and Its Receptor CCR5 and Environmental Factors in the Development of T2DM in Kunming Han Nationality[J]. Journal of Kunming Medical University, 2021, 42(6): 38-44. doi: 10.12259/j.issn.2095-610X.S20210606

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The Interaction among Gene Polymorphisms of RANTES and Its Receptor CCR5 and Environmental Factors in the Development of T2DM in Kunming Han Nationality

doi: 10.12259/j.issn.2095-610X.S20210606

1.
Dept. of Endocrinology，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Sports Department，Kunming Medical University，Kunming Yunnan 650504，China

Received Date: 2021-04-11
Available Online: 2021-07-09
Publish Date: 2021-07-21

Abstract

Abstract

Objective To investigate the interaction among RANTES gene promoter region rs2280788 C/G polymorphism, CCR5 gene promoter region rs1799987 G/A polymorphism and environmental factors in the development of Type 2 diabetes mellitus （T2DM） in the Han ethnic group in Kunming. Methods The general data and peripheral venous blood of 92 Han people with normal blood glucose and 97 Han T2DM patients in Kunming area were collected. Polymorphisms of RANTES gene rs2280788 and CCR5 gene rs1799987 were detected by TaqMan real-time quantitative PCR. Multifactor dimensionality reduction （MDR） was used to analyze the interaction among the gene polymorphisms of RANTES and its receptor and environmental factors in the occurrence of T2DM in Han nationality in Kunming. Results There was an interaction between CCR5 rs1799987 and RANTES rs2280788 （the testing balance accuracy was 0.5314, the training balance accuracy was 0.5820, and the cross validation consistency was 10/10, P < 0.05, OR: 2.0465, 95%CI: 1.1118-3.7672）; There was an interaction between hypertension and central obesity （the testing balance accuracy was 0.7031, the training balance accuracy was 0.7031, the cross validation consistency was 10/10, P < 0.001, OR: 8.1640, 95%CI: 3.8745-17.2026）; No interaction between CCR5 rs1799987 and environmental factors, as well as RANTES rs2280788 and environmental factors was found （P > 0.05）. Conclusions There are interactions between the RANTES gene promoter region -28 （rs2280788） and the CCR5 gene promoter region 59029 （rs1799987） SNP, as well as between hypertension and central obesity, the co-existence of interacting factors will increase the risk of T2DM in Han nationality in Kunming.
- RANTES,
- CCR5,
- Gene polymorphism,
- Type 2 diabetes,
- Interaction

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