Association between NRG1-Erbb4 Polymor- phism and Focal Epilepsy

Xin-yuan CHEN; Hui WU; Ya-xiong MO; Yan-bing HAN; Xin-li CHEN; Wen-ye ZHU; Rui HUANG; Wen TANG

doi:10.12259/j.issn.2095-610X.S20210607

Volume 42 Issue 6

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(6): 82-87

Xin-yuan CHEN, Hui WU, Ya-xiong MO, Yan-bing HAN, Xin-li CHEN, Wen-ye ZHU, Rui HUANG, Wen TANG. Association between NRG1-Erbb4 Polymor- phism and Focal Epilepsy[J]. Journal of Kunming Medical University, 2021, 42(6): 82-87. doi: 10.12259/j.issn.2095-610X.S20210607

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Xin-yuan CHEN, Hui WU, Ya-xiong MO, Yan-bing HAN, Xin-li CHEN, Wen-ye ZHU, Rui HUANG, Wen TANG. Association between NRG1-Erbb4 Polymor- phism and Focal Epilepsy[J]. Journal of Kunming Medical University, 2021, 42(6): 82-87. doi: 10.12259/j.issn.2095-610X.S20210607

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Association between NRG1-Erbb4 Polymor- phism and Focal Epilepsy

doi: 10.12259/j.issn.2095-610X.S20210607

Dept. Of Pharmacy，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-03-16
Publish Date: 2021-06-25

Abstract

Abstract

Objective To determine the effect of the Neuregulin-1 and its receptor ErbB4（NRG1-ErbB4） polymorphisms on focal epilepsy. Methods Three single nucleotide polymorphisms （SNPs） of NRG1 gene and three single nucleotide polymorphisms （SNPs） of ErbB4 gene in 70 patients with focal epilepsy and 64 healthy persons were analyzed by the PCR-SnapShot genotyping methods.The samples were all from the First Affiliated Hospital of Kunming Medical University from March to July, 2020. Results It was found that focal epilepsy was correlated with polymorphism of NRG1 （SNP rs35753505, T > C）, the distribution of genotype （ P = 0.007） and allele （P = 0.005） of NRG1 （SNP rs35753505, T > C） was statistically significant （ P < 0.005）. Meanwhile, ErbB4 gene polymorphisms of NRG1 downstream receptors was analyzed firstly, and two SNPs was found to be associated with focal epilepsy, ErbB4 SNP（rs839523, P = 0.026） and its allele （P = 0.013）, ErbB4 SNP（rs707284, P = 0.038） and its allele （P = 0.018）. However, no statistically significant association was found between NRG1（rs6994992, rs62510682）, ErbB4（rs7598440） polymorphisms and focal epilepsy. Conlusions The susceptibility of focal epilepsy carrying NRG1（SNP, rs35753505） and ErbB4（rs839523, rs707284） mutation homozygous has increased. NRG1-ErbB4 polymorphisms might play an important role together in the susceptibility to partial epilepsy.
- Neuregulin-1,
- Receptors,
- ErbB-4,
- Partial epilepsy,
- Polymorphism

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References(26)

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