Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department

Juan LI; Jun ZHANG; Qiao-ling ZHENG; Pu-qiong FENG; Jin HE

doi:10.12259/j.issn.2095-610X.S20210614

Volume 42 Issue 6

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(6): 110-114

Juan LI, Jun ZHANG, Qiao-ling ZHENG, Pu-qiong FENG, Jin HE. Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department[J]. Journal of Kunming Medical University, 2021, 42(6): 110-114. doi: 10.12259/j.issn.2095-610X.S20210614

Citation:

Juan LI, Jun ZHANG, Qiao-ling ZHENG, Pu-qiong FENG, Jin HE. Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department[J]. Journal of Kunming Medical University, 2021, 42(6): 110-114. doi: 10.12259/j.issn.2095-610X.S20210614

Citation:

Juan LI, Jun ZHANG, Qiao-ling ZHENG, Pu-qiong FENG, Jin HE. Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department[J]. Journal of Kunming Medical University, 2021, 42(6): 110-114. doi: 10.12259/j.issn.2095-610X.S20210614

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Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department

doi: 10.12259/j.issn.2095-610X.S20210614

Dept. of Clinical Pharmacy，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-04-19
Available Online: 2021-07-09
Publish Date: 2021-07-21

Abstract

Abstract

Objective To provide reference for clinical rational use of vancomycin through analyzing the monitoring results of vancomycin plasma concentration in patients with intracranial infection or/and pulmonary infection after neurosurgery in our hospital. Methods We collected the related information of 119 neurosurgical patients with intracranial infection and/or pulmonary infection, and the monitoring results of vancomycin blood concentration and the influencing factors were analyzed. Results With the dosage of vancomycin 1g, IVGTT, q12h, only 26.1% of the patients were within the reference range （10-20 mg/L）and 68.1% were lower than the reference range. Multiple linear regression analysis showed that only creatinine clearance rate had significant effect on the trough concentration of vancomycin. Conclusion When patients with postoperative infection in neurosurgery are treated with vancomycin, the dosage of 1g, IVGTT, q12h may not reach the effective blood concentration, so the initial dosage should be selected according to the creatinine clearance rate of patients, and the blood concentration of vancomycin should be closely monitored, and the dosage regimen should be adjusted according to the situation of patients and the detection results timely.
- Neurosurgery,
- Vancomycin,
- Blood concentrations,
- Influence factor

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References(15)

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