Correlation Between the Neutrophil-lymphocyte Ratio and Renal Damage in Systemic Lupus Erythematosus Patients

Li LIAO; Xue LOU; Ruo-tong ZHAO; Xiang-yu WANG; Yi-fan Yang; Shuang LIU; Jian XU

doi:10.12259/j.issn.2095-610X.S20210617

Volume 42 Issue 6

Jul. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(6): 72-75

Li LIAO, Xue LOU, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan Yang, Shuang LIU, Jian XU. Correlation Between the Neutrophil-lymphocyte Ratio and Renal Damage in Systemic Lupus Erythematosus Patients[J]. Journal of Kunming Medical University, 2021, 42(6): 72-75. doi: 10.12259/j.issn.2095-610X.S20210617

Citation:

Li LIAO, Xue LOU, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan Yang, Shuang LIU, Jian XU. Correlation Between the Neutrophil-lymphocyte Ratio and Renal Damage in Systemic Lupus Erythematosus Patients[J]. Journal of Kunming Medical University, 2021, 42(6): 72-75. doi: 10.12259/j.issn.2095-610X.S20210617

Citation:

Li LIAO, Xue LOU, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan Yang, Shuang LIU, Jian XU. Correlation Between the Neutrophil-lymphocyte Ratio and Renal Damage in Systemic Lupus Erythematosus Patients[J]. Journal of Kunming Medical University, 2021, 42(6): 72-75. doi: 10.12259/j.issn.2095-610X.S20210617

PDF( 603 KB)

Correlation Between the Neutrophil-lymphocyte Ratio and Renal Damage in Systemic Lupus Erythematosus Patients

doi: 10.12259/j.issn.2095-610X.S20210617

Dept. of Rheumatology and Immunology, the First Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650032, China

Received Date: 2021-04-11
Available Online: 2021-07-03
Publish Date: 2021-07-21

Abstract

Abstract

Objective To evaluate the association between neutrophil-lymphocyte ratio （NLR） and renal damage in patients with systemic lupus erythematosus （SLE）. Methods A total of 410 patients with SLE from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Kunming Medical University were selected. According to whether accompanied by renal involvement, patients with SLE were divided into non-lupus nephritis group （non-LN group） and lupus nephritis group （LN group）. The differences in NLR between the two groups were compared, and the correlation between NLR and renal damage was analyzed. Results The NLR of LN group was significantly higher than that of SLE patients in non-LN group, and the difference wsa statistically significant （P < 0.05）. The NLR of SLE patients were positively correlated with leukocyte count, neutrophils count, serum creatinine, blood urea nitrogen, ESR, CRP, PCT and 24-hour urine protein, and negatively correlated with lymphocyte count, total protein, albumin and globulin, respectively. Conclusion NLR can be used as an auxiliary index to evaluate renal damage in SLE patients.
- Neutrophil-lymphocyte ratio,
- Systemic lupus erythematosus

FullText(HTML)

References(14)

References

[1]	Tsokos G C,Lo M S,Costa Reis P,et al. New insights into the immunopathogenesis of systemic lupus erythematosus[J]. Nat Rev Rheumatol,2016,12(12):716-730. doi: 10.1038/nrrheum.2016.186
[2]	Hu Z D,Sun Y,Guo J,et al. Red blood cell distribution width and neutrophil/lymphocyte ratio are positively correlated with disease activity in primary Sjogren's syndrome[J]. Clin Biochem,2014,47(18):287-290. doi: 10.1016/j.clinbiochem.2014.08.022
[3]	Mercan R,Bitik B,Tufan A,et al. The Association Between Neutrophil/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis[J]. J Clin Lab Anal,2016,30(5):597-601. doi: 10.1002/jcla.21908
[4]	Tamirou F,Houssiau F A. Management of Lupus Nephritis[J]. J Clin Med,2021,10(4):670. doi: 10.3390/jcm10040670
[5]	Jaryal A,Vikrant S. Current status of lupus nephritis[J]. Indian J Med Res,2017,145(2):167-178.
[6]	Korbet S M,Lewis E J,Schwartz M M,et al. Factors predictive of outcome in severe lupus nephritis. Lupus Nephritis Collaborative Study Group[J]. Am J Kidney Dis,2000,35(5):904-914. doi: 10.1016/S0272-6386(00)70262-9
[7]	Mittal B,Rennke H,Singh A K. The role of kidney biopsy in the management of lupus nephritis[J]. Curr Opin Nephrol Hypertens,2005,14(1):1-8. doi: 10.1097/00041552-200501000-00002
[8]	Hochberg M C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J]. Arthritis Rheum,1997,40(9):1725.
[9]	Yuan Q,Wang J,Peng Z,et al. Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease:results from the Chinese Cohort Study of Chronic Kidney Disease(C-STRIDE)[J]. Transl Med,2019,17(1):86. doi: 10.1186/s12967-019-1808-4
[10]	Solak Yalcin,Yilmaz Mahmut Ilker,Sonmez Alper,et al. Neutrophil to lymphocyte ratio independently predicts cardiovascular events in patients with chronic kidney disease[J]. Clin Exp Nephrol,2013,17(4):532-40. doi: 10.1007/s10157-012-0728-x
[11]	Wang Y,Yuan A,Yu C. Correlation between microalbuminuria and cardiovascular events[J]. Int J Clin Exp Med,2013,6(10):973-978.
[12]	Koroshi A. Microalbuminuria,is it so important?[J]. Hippokratia,2007,11(3):105-107.
[13]	De Rosa M,Rocha A S,De Rosa G,et al. Low-Grade Proteinuria Does Not Exclude Significant Kidney Injury in Lupus Nephritis[J]. Kidney Int Rep,2020,5(7):1066-1068. doi: 10.1016/j.ekir.2020.04.005
[14]	Ugolini-Lopes M R,Seguro L P C,Castro M X F,et al. Early proteinuria response:a valid real-life situation predictor of long-term lupus renal outcome in an ethnically diverse group with severe biopsy-proven nephritis?[J]. Lupus Sci Med,2017,4(1):e000213. doi: 10.1136/lupus-2017-000213

Relative Articles(20)

Relative Articles

[1]	Chunli CHEN, Daolin CUI. Bioinformatics-Based Analysis of the Roles of MX1，IFI44， and STAT1 in Lupus Nephritis. Journal of Kunming Medical University, 2024, 45(12): 1-10.
[2]	Hong ZHU, Qiong DU, Zhengwei ZHAO, Liping CHEN, Muli XU, Yungui TU. Analysis of Blood Cells and Establishment of Reference Interval of Elderly Derivative Index in Anning Area of Yunnan Province. Journal of Kunming Medical University, 2024, 45(6): 145-153. doi: 10.12259/j.issn.2095-610X.S20240620
[3]	Bowen TAN, Yun LIANG, Huan CHEN, Yi LEI, Yuhan WANG, Yan TIAN. The Prognostic Value of Preoperative Peripheral Blood Inflammatory Markers Combined with Tumor Markers in Resectable Colon Cancer Patients. Journal of Kunming Medical University, 2024, 45(12): 1-5.
[4]	Feng SHEN, Yifan YANG, Ru BAI, Shu LI, Shuang LIU, Jian XU. Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2024, 45(10): 45-49. doi: 10.12259/j.issn.2095-610X.S20241007
[5]	Li LI, Ruixian ZHANG. Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2024, 45(6): 161-165. doi: 10.12259/j.issn.2095-610X.S20240622
[6]	Lihua MA, Xiangyu WANG, Yifan YANG, Ruotong ZHAO, Xiaoyan FENG, Jian XU. Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2022, 43(2): 78-81. doi: 10.12259/j.issn.2095-610X.S20220209
[7]	Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201
[8]	Xue LOU, Li LIAO, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan YANG, Shuang LIU, Jian XU. Clinical Significance of Anti-dsDNA Antibody，Complement C3 and Other Laboratory Indicators in the Diagnosis of Renal Injury in Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2021, 42(2): 49-53. doi: 10.12259/j.issn.2095-610X.S20210214
[9]	Huang Ying , Xu Kun Jing , Pu Dong , Li Xiao Fei , Chen Hai Yun , Wu Yan , Wang Li Hua , Li Wen Ming , Luo Yun , He Hua . . Journal of Kunming Medical University, 2019, 40(02): 116-122.
[10]	Chen Xian Wei , Lu Xiang Dong , Wang Yong Feng , Zhao Die Bo , Yang Xu , Wang Wen Xuan , Fan Yan Xin , Zhang Hui , Zhao Bin . . Journal of Kunming Medical University, 2019, 40(06): 76-79.
[11]	Chen Yi . Clinical Study of Glucosidorum Tripterygll Totorum Combined with Prednisone Acetate and Hydroxychloroquine Sulfate in Treatment of Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2018, 39(03): 98-102.
[12]	Dai Bai Zhang , Ren Chao Feng , Zheng Qin Ling , Yang Yan Xia , Li Mei Hua . Changes in Composition of Lymphocytes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2017, 38(06): 64-67.
[13]	Yuan Shan . . Journal of Kunming Medical University,
[14]	Xiao Xin . . Journal of Kunming Medical University,
[15]	Li Jing . . Journal of Kunming Medical University,
[16]	Zhang Li Guo . . Journal of Kunming Medical University,
[17]	Zhang Li Guo . . Journal of Kunming Medical University,
[18]	Yang Xiao Lei . . Journal of Kunming Medical University,
[19]	. Study on the Expression of CD45RO+ and CD45RA+T Lymphocytes in Peripheral Blood of Children Patients with Infectious Mononucleosis. Journal of Kunming Medical University,
[20]	Li Xiao Ming . . Journal of Kunming Medical University,