Effect of <i>Ginsenoside</i> Rg1 on Renal Protection in Type 2 Diabetic Rats

Er-shu RUAN; Shuo WANG; Hui SU; Feng-qiong YIN; Zhong-yi QIAN; Jian-yu YANG

doi:10.12259/j.issn.2095-610X.S20210625

Volume 42 Issue 6

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(6): 50-55

Er-shu RUAN, Shuo WANG, Hui SU, Feng-qiong YIN, Zhong-yi QIAN, Jian-yu YANG. Effect of Ginsenoside Rg1 on Renal Protection in Type 2 Diabetic Rats[J]. Journal of Kunming Medical University, 2021, 42(6): 50-55. doi: 10.12259/j.issn.2095-610X.S20210625

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Er-shu RUAN, Shuo WANG, Hui SU, Feng-qiong YIN, Zhong-yi QIAN, Jian-yu YANG. Effect of Ginsenoside Rg1 on Renal Protection in Type 2 Diabetic Rats[J]. Journal of Kunming Medical University, 2021, 42(6): 50-55. doi: 10.12259/j.issn.2095-610X.S20210625

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Effect of Ginsenoside Rg1 on Renal Protection in Type 2 Diabetic Rats

doi: 10.12259/j.issn.2095-610X.S20210625

1.
Dept. of Pharmacology，School of Basic Medicine，Kunming Medical University 650051
2.
Pharmacy Department，Jinan People’s Hospital 271199
3.
Dept. of Neurology，The Second Affiliated Hospital of Kunming Medical University
4.
Experimental Center of Morphology，Kunming Medical University，Kunming Yunnan 650051，China

Received Date: 2021-03-24
Publish Date: 2021-06-25

Abstract

Abstract

Objective To investigate the protective effect and mechanism of ginsenoside Rg1 on the kidneys of type 2 diabetic rats. Methods A high-sugar and high-fat diet + low-dose streptozotocin （STZ） was used to establish a type 2 diabetic rat model. Ginsenoside Rg1 was administered to the stomach for 4 weeks, and blood creatinine （Scr）、uric acid （UA） and urea nitrogen （BUN） were measured. Take kidney tissue sections for HE staining to observe the pathological changes of kidney tissue; Western blot was used to detect angiotensin Ⅱ type 1 receptor （AT1）, transforming growth factor-β1 （TGF-β1） and metalloproteinase-9 in rat kidney tissue expression level. Results BUN of type 2 diabetic rats was significantly higher than that of the normal group, but Scr and UA were not statistically significant compared with the normal group. After different doses of ginsenoside Rg1, the BUN value decreased, and the BUN of the metformin group also decreased, but there was no statistical difference in the changes of Scr and UA （P > 0.05）. The renal coefficient of diabetic rats was higher than that of the normal group, and the renal body ratio decreased after treatment with ginsenoside Rg1 and metformin （ P < 0.05）. The expressions of AT1 and TGF-β1 in the kidneys of diabetic rats were higher than those in the normal group, and the expressions decreased after being given different doses of ginsenoside Rg1 and metformin treatment （ P < 0.05）. The expression of MMP9 decreased in the kidneys of diabetic rats, but increased after treatment with ginsenoside Rg1 and metformin （ P < 0.05）. Conclusions Ginsenoside Rg1 can protect the kidney from damage in rats. Its molecular mechanism may be through inhibiting the activation of the RAS system, inhibiting the expression of TGF-β1, promoting the hydrolysis of extracellular matrix, and reducing the degree of kidney damage.
- Ginsenoside Rg1,
- Type 2 diabetes,
- RAS system of kidney,
- Protective effect of kidney and mechanism

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References(26)

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