Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer

Fang WANG; Rong ZHAO; Hong ZHENG

doi:10.12259/j.issn.2095-610X.S20210626

Volume 42 Issue 6

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(6): 98-102

Fang WANG, Rong ZHAO, Hong ZHENG. Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer[J]. Journal of Kunming Medical University, 2021, 42(6): 98-102. doi: 10.12259/j.issn.2095-610X.S20210626

Citation:

Fang WANG, Rong ZHAO, Hong ZHENG. Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer[J]. Journal of Kunming Medical University, 2021, 42(6): 98-102. doi: 10.12259/j.issn.2095-610X.S20210626

Citation:

Fang WANG, Rong ZHAO, Hong ZHENG. Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer[J]. Journal of Kunming Medical University, 2021, 42(6): 98-102. doi: 10.12259/j.issn.2095-610X.S20210626

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Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer

doi: 10.12259/j.issn.2095-610X.S20210626

Dept. of Medical Oncology，The First People’s Hospital of Yunnan Province，Kunming Yunnan 650032，China

Received Date: 2021-03-08
Available Online: 2021-07-09
Publish Date: 2021-07-21

Abstract

Abstract

Objective To observe the effect of Kan Fu Xin combined with Montmorillonite on the prevention and treatment of radiation-induced oral mucositis in patients with Head and Neck Cancer. Methods In this trial, we included 138 patients with head and neck cancer who underwent radiotherapy from the First People’ s Hospital of Yunnan Province from April 2018 to February 2019, which were randomly divided into the experimental group （69 cases） and the control group （69 cases）. The control group received routine care and symptomatic treatment. The experimental group gave Kan Fu Xin combined with Montmorillonite protection on the basis of routine care, and adjusted 1 bag of Montmorillonite and appropriate amount of Kan Fu Xin fluid into a paste. Then contained in the mouth for 5 minutes before each radiotherapy and before going to bed. We observed the degree of radiation-induced oral mucositis damage, the degree of oral radiation pain, the completion time of radiotherapy and recovery, etc. Results We found that the experimental group had a late onset of radiation-induced oral mucositis and a shorter recovery time than the control group （P < 0.05）. At the 3rd and 4th week of radiotherapy, the RTOM of the experimental group was mainly mild to moderate, and the control group was mainly moderate and severe. At the 5th and 6th week, the RTOM of the experimental group was mainly moderate, and the control group was mainly severe. At the 3rd to 6th week, there was a statistically significant difference in the incidence of RTOM between the two groups （P < 0.01）. The average radiotherapy time of the experimental group was less than that of the control group, and the difference was statistically significant （P < 0.05）. Conclusion Kan Fun Xin combined Montmorillonite can significantly reduce the symptoms of patients with radioactive oral mucositis, ensure that radiotherapy is completed on time, and can be widely used in clinical.
- Radiation-induced oral mucositis,
- Radiotherapy,
- Kan Fu Xin,
- Montmorillonite

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References(14)

References

[1]	National Cancer Institute PDQ. Oral mucositis. In health professional version of oral complications of hemotherapy and head/neck radiation[OL]. [2016-05-18]. http://www.cancer.gov/about-cancer/treatment/side-effects/mouth-throat/oral-complications-hp-pdqsection/_337（4 September 2016.date last aecessed）.
[2]	邱敏,魏娇,王甲一,等. 放射性口炎治疗的研究进展[J]. 中华口腔医学杂志,2015,50(10):593-597.
[3]	陈枫,朱磊,朱锡旭,等. 个性化口腔定位支架在头颈部肿瘤患者调强放疗中的应用[J]. 医学研究生学报,2017,30(5):491-494.
[4]	Mallick S,Benson R,Rath GK. Radiation induced oral mucositis:a review of current literature on prevention and management[J]. Eur Arch Otorhinolaryngol,2016,273(9):2285-2293. doi: 10.1007/s00405-015-3694-6
[5]	张圣林,钟大仓,张冠男,等. 重组人表皮生长因子凝胶防治放射性口腔黏膜炎的临床疗效观察[J]. 医学研究生学报,2018,31(1):56-59.
[6]	Kock I,Mirhosseini M,Lau F,et al. Conversion of karnofsky performance status(KPS)and eastern cooperative oncology group performance status(ECOG)to palliative performance cale(PPS),and the interchangeability of PPS and KPS in prognostic tools[J]. J Palliat Care,2013,29(3):163-169. doi: 10.1177/082585971302900305
[7]	龚芸,张丽,冯泽会,等. 口炎清颗粒防治鼻咽癌患者放射性口腔炎的疗效观察[J]. 华西口腔医学杂志,2016,34(1):37-40. doi: 10.7518/hxkq.2016.01.008
[8]	张盈明,李红,王家霞. 口炎清颗粒联合重组牛碱性成纤维细胞生长因子治疗急性放射性口炎的临床疗效[J]. 中成药,2019,41(2):478-480. doi: 10.3969/j.issn.1001-1528.2019.02.051
[9]	王庆兰,邱艳茹. 不同漱口液治疗放射性口腔炎疗效观察[J]. 蚌埠医学院学报,2014,39(2):270-271.
[10]	庄玲. 康复新液联合美洲大蠊研末防治放射性口腔黏膜炎的疗效观察[J]. 实用药物与临床,2019,22(5):501-503.
[11]	谭巧云,满红霞,那凯歌,等. 美洲大蠊提取物对口腔溃疡大鼠模型的作用[J]. 中国临床药理学杂志,2016,32(11):1014-1016.
[12]	白芳,杜容香,符爱珠,等. 复方氯已定含漱液联合口腔清洁冲洗器在口腔护理中的应用[J]. 当代护士(中旬刊),2016,24(9):119-120.
[13]	严齐会,林海升,卓文杰,等. 口炎清颗粒对头颈部恶性肿瘤患者放疗后放射性口腔黏膜炎的防治作用[J]. 中国药房,2017,28(27:3778-3781. doi: 10.6039/j.issn.1001-0408.2017.27.09
[14]	Luo Y,Feng Z,etal. Effect of kangfuxin solution on chemo/radiotherapy-induced mucositis in nasopharyngeal carcinoma patients:A multicenter,prospective randomized phase Ⅲ clinical study[J]. Evid Based Complement Alternat Med,2016,2016:8692343.

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